inflammation cardiac Articles
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Cardiovascular Consequences of Acute Kidney Injury
Annotations Acute kidney injury (AKI) is recognized as a potential risk factor for future cardiovascular events, especially heart failure. Up to 60% of patients with severe AKI who are admitted to an intensive care unit (ICU) die; the long-term risk of death associated with AKI is also increased. Preclinical models and biomarkers have identified several likely pathways, apparently involving ...
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What causes heart failure with preserved ejection fraction (HFpEF)?
Heart failure with preserved ejection fraction (HFpEF) is a multifactorial and multisystemic disorder that represents more than 50% of all heart failure cases.[1] Epidemiologic data from the Framingham Study, an international cohort study, shows a rapid increase in the prevalence of HFpEF over the past three decades, from 41% to 56% and, conversely, a decrease in the prevalence of HFrEF from 44% ...
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Emerging therapy for HFpEF: SGLT2 inhibitors
Recent clinical trials investigating sodium-glucose cotransporter 2 inhibitors (SGLT2i) have highlighted that this drug is highly effective in treating patients with heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disease which accounts for more than half of all heart failure (HF) hospital admissions and is an increasing disease burden. [1] The prevalence of HFpEF is ...
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