inflammatory disease Articles
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Microfluidic tools to investigate pathologies in the blood microcirculation
We show how microfluidics technology can be used to fabricate simple and innovative biomimetic tools to shed new light on physiopathological events occurring in the blood microcirculation. Examples of applications are given in the context of the acute respiratory distress syndrome (ARDS), an inflammatory disease of the lung triggered by a massive arrest of white blood cells in the lung ...
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Editorial: Research, Development and Clinical Trials for Peptide-Based Vaccines
From the eradication of smallpox through to the global response to the COVID-19 pandemic, vaccines have been a cornerstone in the fight against infectious diseases in humans and livestock since the 18th century. Although vaccines against COVID-19 are unlikely to eradicate the disease in the way that the smallpox vaccine did, they have proved very effective in preventing death and hospitalisation, ...
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ELife: T Interferon Suppresses Inflammatory Diseases by Balancing the Microbiome
The maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls the response to acute microbial infection through the involvement of STAT1 transcription factors. However, the contribution of tonic levels of interferon to immune homeostasis in the absence of acute infection remains largely unexplored. The ...
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Understanding IL-36 Cytokines: Their Role & Potential in Treating Inflammatory Diseases
Introduction to IL-36 Family Twenty years ago, Interleukin 36 (IL-36) was discovered as a member of the IL-1 superfamily. Its gene is located on chromosome 2 in an IL gene cluster, including IL1A - IL1B - IL37 - IL36G - IL36A - IL36B - IL36RN - IL38 - IL1RN, with IL-36 encoding genes transcribed far away from the centromere. There are four known subtypes of IL-36, which have been renamed multiple ...
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The Promoter of Life Evolution—Superoxide Dismutase
More and more scientific evidence shows that reactive oxygen species (ROS) and reactive nitrogen species are important mediators of signaling events in cells, especially the superoxide anion in reactive oxygen species. If the content of superoxide anion in the human body is too high, it may induce various diseases, including pro-inflammatory diseases (pro-inflammatory diseases), cardiovascular ...
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The Function and Application of the Magic Superoxide Dismutase
Some substances can easily interact with the oxygen in the air when exposed to the air, causing chemical changes in the substance. This is the process of oxidation. Sun exposure, air pollution, radiation, etc. will cause the human skin to produce a large amount of superoxide free radicals, and its strong oxidizing ability will accelerate the speed of skin oxidation, and may even cause serious ...
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Recapitulating the Multifaceted Inflammatory Environment of the Intestine In Vitro
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. With access to a donor-derived cell biobank and the ability to recapitulate region-specific environments of the intestine, Altis Biosystems is working toward the development of an in vitro RepliGut® model to accurately recapitulate the complex intestinal ...
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Science: Blocking fibrin holds promise for the treatment of periodontal disease
In a new study, researchers from the National Institute of Dental Craniofacial Research (NIDCR) have found that blocking the function of a coagulation protein prevents bone loss caused by periodontal (gingival) disease in mice. According to animal and human data, they found that the accumulation of this clotting protein called fibrin triggers an excessive immune response that damages the gingiva ...
By Matexcel
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Applications of Diamine Oxidase
Diamine oxidase (DAO) is an intracellular enzyme that catalyzes diamine in mucosal or ciliated epithelial cells of the mammalian small intestine. It protects the intestinal mucosa by regulating intracellular ion homeostasis, influencing conduction pathways, and promoting cellular repair. Serum DAO is elevated in small intestinal mucosal barrier failure or in intestinal mucosal cell necrosis; ...
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Shining a Light on Drug Delivery: The Rise of Fluorescent Liposomes
Imagine tiny spheres, smaller than a red blood cell, glowing as they navigate the labyrinthine corridors of the human body. These aren't fireflies, they're fluorescent liposomes, a cutting-edge tool in the world of drug delivery and biomedical research. What are liposomes? Liposomes are microscopic bubbles made from phospholipids, the same fatty molecules that make up cell membranes. These ...
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Symberix Featured in PNAS
Durham, NC (April 28, 2020) - A review article published in PNAS highlights Symberix's efforts to understand the role of the human microbiota in drug efficacy and toxicity. Symberix co-founder Matt Redinbo is featured in the article alongside other leaders from the emerging field of “pharmacomicrobiomics” -- the study of mechanisms behind the microbial impact on drug metabolism. ...
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What is FGL2?
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
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Symberix Featured in Nature
Durham, NC (February 3, 2020) - An article in Nature highlights Symberix's efforts to understand the complex relationship between drugs and the microbiome. The paper discusses recent contributions to the emerging field of “pharmacomicrobiomics” -- the study of how microbes impact drug disposition, efficacy, and toxicity. Symberix is developing bacteria-targeted small molecules that ...
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Enzymes for Disease Diagnosis: An Overview
Enzymes are protein molecules that catalyze chemical reactions in living organisms. They are involved in many metabolic processes and play a critical role in maintaining the health of the body. In recent years, enzymes have been widely used in disease diagnosis, providing a quick and accurate way to detect and monitor diseases. Enzymes for disease diagnosis can be divided into two categories: ...
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Enzyme Therapy and Cancer
Two groups of experiments were conducted at the Michael Rees Hospital in Chicago. The experimental group is 21 to 31 years old, and the control group is 69 to 100 years old. Researchers found that the salivary amylase of young people is more than 30 times that of older people. This is why young people can easily digest sugar, bread, noodles, pastries, and cooked food. But these foods accelerate ...
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Applications of Cell-penetrating Peptides
Cell-penetrating peptides (CPPs) are short peptides that facilitate cellular intake and uptake of molecules ranging from nano-size particles to small chemical compounds to large fragments of DNA. As a versatile peptide, CPP has been widely used for diagnostic and therapeutic applications. 1. Oligo and siRNA Transport As an important means for targeted therapy of specific genes, oligonucleotides ...
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A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics
Tumor Necrosis Factor Alpha (TNF-a) is a potent cytokine that is over-expressed by cells during chronic intestinal inflammation. Furthermore, TNF-a represents the most validated clinical target for ulcerative colitis (UC) and inflammatory bowel diseases (IBD) with multiple emerging neutralizing/inflammation-reducing therapeutics targeting this cytokine for inactivation. TNF-a activation of ...
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5 ways to keep asthma in check
Asthma rates have been on the rise for some time - in 2009 nearly 1 in 12 Americans were diagnosed with the long-term inflammatory disease that restricts airways and makes it difficult to breathe. Other symptoms include coughing, wheezing and chest tightness, and these often get worse when the patient is also fighting a common cold or flu. Asthma affects people of all ages, but especially ...
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Alleviation of DSS-induced colitis via Lactobacillus acidophilus treatment in mice
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment ...
By KoBioLabs
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Laser Application in Periodontics
The use of lasers for periodontal treatment has become more complicated because the periodontium consists of both hard and soft tissues. Non-surgical Periodontal Therapy Dental plaque is known as the principal etiologic factor for the inflammatory periodontal disease; therefore, it is evident that treatment of the disease is dependent upon how much the plaque and its retentive factors are ...
By PIOON
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