Inflammatory Diseases Articles & Analysis
50 articles found
These chemokines protein allows researchers to study the functional dynamics of chemokine-receptor interactions in controlled environments, facilitating the development of targeted therapies for a range of diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. ...
Customized assays can help identify key cytokines involved in immune regulation. Infectious Disease Studies: Cytokines play a significant role in the host response to infections. By measuring cytokine levels, researchers can gain insights into the pathogenesis of infectious diseases and the effectiveness of potential treatments. Autoimmune and ...
Their size, ease of handling, and well-characterized immune system make them ideal candidates for studying disease mechanisms and therapeutic interventions. Understanding the cytokine and chemokine profiles in rats can provide insights into human diseases, as many of the biological pathways are conserved across species. ...
Antibody drugs are a kind of drugs that treat diseases through artificially synthesized antibodies, achieving therapeutic purposes by specifically binding with target molecules. ...
Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies, which bind specifically to target molecules for therapeutic purposes. ...
It is involved in the breakdown of invading microorganisms and cellular debris during inflammatory responses. By degrading harmful entities, elastase helps in modulating immune responses and tissue repair. ...
Autophagy has also been implicated in pathological conditions including neurodegenerative diseases, cancer, and inflammatory diseases. Modulation of autophagy has become a potential therapeutic target in human diseases. ...
This test is commonly used to monitor a patient's immune response to biological agents or other drugs, especially in the treatment of chronic diseases such as autoimmune diseases, certain cancers, and inflammatory diseases. ...
In post-translational modification (PTM) of proteins, ubiquitination is considered one of the most critical processes in regulating cellular functions and various diseases. The identification of ubiquitination sites becomes very crucial for understanding the mechanisms of ubiquitination-related biological processes. ...
The versatility of nanobodies has led to the development of a wide range of nanobody-based drug delivery systems for various diseases, including cancer, infectious diseases, and inflammatory disorders. For example, nanobodies have been used to deliver anti-inflammatory drugs to inflamed tissues, resulting in reduced inflammation ...
Th1 cells suppress B-cell function and mediate cellular immunity by secreting inflammatory cytokines such as interleukin (IL) and interferon (IFN), and enhance anti-infective immunity by phagocytes. ...
The future of antibody-drug conjugate development appears to be very promising, with prospective improvements and advancements in multiple areas: Improved target selection: With the advancement in genomics and proteomics, the future may bring a better understanding of disease biology, leading to the identification of more disease-specific targets for ADCs. ...
Moreover, TREM1 activation augments the oxidative burst and microbicidal activity of phagocytes, illustrating its role in host defense mechanisms. Implications in Disease The dysregulation of TREM1 has been implicated in an array of inflammatory and infectious diseases. ...
Candidate drugs like ARV110 and ARV-471 have entered Phase I/II clinical trials, indicating the potential of PROTACs in the treatment of cancer and other diseases. The high selectivity, resistance-overcoming capabilities, and ability to target previously undruggable proteins make PROTACs effective in various diseases, including neurological disorders, ...
Diagnostic potential: Fluorescent liposomes can be loaded with imaging agents for specific diseases, potentially enabling non-invasive diagnosis and monitoring of various conditions. ...
Their immune-modulatory abilities make them a sought-after tool in treating autoimmune diseases, while their differentiation potential is harnessed for tissue repair and regeneration. In a clinical context, MSCs are instrumental in treating osteoarthritis, inflammatory bowel disease, graft-versus-host disease, myocardial ...
It usually binds to its inhibitory protein in a non-activated state in the form of P50-P65 dimer. Many inflammatory responses are strongly associated with NF-κB activation. By combining CPP (8K, octa-yLysine) with NF-κB essential regulator binding domain (NBD), Dave et al. treated mice with inflammatory bowel disease by ...
Furthermore, MMP-3 is a reliable biomarker for assessing disease activity, imaging monitoring, predicting disease outcomes, and treatment response in rheumatoid arthritis [4]. MMP-3 and Ankylosing Spondylitis (AS) AS is a chronic inflammatory disease that primarily affects the spine and sacroiliac joints. ...
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). ...
The binding of IL-36 Ra to IL-1R6 does not lead to the recruitment of IL-1RAcP. Therefore, the pro-inflammatory cascade reaction is not initiated, realizing the anti-inflammatory characteristics of IL-36 Ra. ...