Inflammatory Immune Disorders Articles & Analysis
10 articles found
Glycans are often found on the surface of pathogens, including viruses and bacteria, and can serve as targets for the immune system. Microarray technology can be used to identify which glycan structures are recognized by immune cells or antibodies, helping researchers design vaccines that elicit a robust immune response. By printing arrays of ...
Nanobodies, also known as single-domain antibodies, have gained much attention in recent years due to their potential in various biomedical applications including drug delivery systems. Nanobodies are small antibody fragments derived from naturally occurring heavy-chain antibodies found in camelids, such as camels and llamas. They are composed of a single monomeric variable domain, making them ...
Functionally, TREM1 acts as an amplifier of inflammatory responses. Upon activation, it potentiates the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6), thereby exacerbating the inflammatory cascade. ...
Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system exhibits selective degradation of target proteins, with folate serving as a key ligand. In this study, the ...
They induce the production of inflammatory mediators, increase vascular permeability, and promote the recruitment of immune cells to the site of inflammation. ...
These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. ...
In honor of National Fibromyalgia Awareness Day this month, we are doing our part to set the record straight on Fibromyalgia, a condition the MayoClinic calls “one of the most misunderstood disorders in medicine today.” Once thought to be an autoimmune or inflammatory disorder, specialists now agree that fibromyalgia is a disorder of the nervous system. It most commonly affects women ...
Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated lipid peroxidation with further development of atherosclerotic alterations and diabetes. We ...
HBOT is a very effective adjunctive treatment for Rheumatoid Arthritis procedures Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that can affect the lining of the joints and cause painful swelling that will result in the erosion of bones and the deformation of joints, which aggravated, leads to physical disabilities. As an autoimmune ...
Ankylosing Spondylitis (AS) is a rheumatic disease and almost 50% of the affected patients suffer from osteoporosis. The ratio of Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Osteoprotegerin (OPG) has become an important marker to assess the status of systemic bone metabolism and has been shown to be dysregulated in AS patients. Combined Low-Dose Radon- and Hyperthermia Therapy ...