inflammatory response Articles
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Ssd1 is integral to host defense peptide resistance in candida albicans
Candida albicans is usually a harmless human commensal. Because inflammatory responses are not normally induced by colonization, antimicrobial peptides are likely integral to first-line host defense against invasive candidiasis. Thus, C. albicans must have mechanisms to tolerate or circumvent molecular effectors of innate immunity and thereby colonize human tissues. Prior studies demonstrated ...
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Ssd1 is integral to host defense peptide resistance in candida albicans
Candida albicans is usually a harmless human commensal. Because inflammatory responses are not normally induced by colonization, antimicrobial peptides are likely integral to first-line host defense against invasive candidiasis. Thus, C. albicans must have mechanisms to tolerate or circumvent molecular effectors of innate immunity and thereby colonize human tissues. Prior studies demonstrated ...
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Radiation-induced genomic instability: manifestations and mechanisms
There is considerable evidence that delayed death, gene mutations and a variety of chromosomal abnormalities can be demonstrated in cells that are not themselves irradiated but are the progeny of cells exposed to ionising radiation many cell divisions previously. These effects are collectively referred to as radiation-induced genomic instability. At present, we have limited understanding of the ...
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Oxygen therapy for rheumatology
HBOT is a very effective adjunctive treatment for Rheumatoid Arthritis procedures Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that can affect the lining of the joints and cause painful swelling that will result in the erosion of bones and the deformation of joints, which aggravated, leads to physical disabilities. As an autoimmune disorder, rheumatoid arthritis ...
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Inflammation, Immunity and Cancer
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune ...
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Has the future of complement therapeutics arrived?
Silence Therapeutics, a pioneer in the development of novel small interfering RNA (siRNA) therapeutics, and Mallinckrodt plc, a global biopharmaceutical company, announced the submission of a clinical trial application (CTA) for SLN501, a siRNA therapy targeting the complement C3 protein, on March 23, 2022. Silence will receive a $3 million milestone payment from Mallinckrodt as a result of the ...
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Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated vaccine against herpes simplex virus type 1 (HSV-1), a widespread human pathogen that can cause ...
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RelB Modulation of Ikappa Balpha Stability as a Mechanism of Transcription Suppression of Interleukin-1alpha (IL-1alpha ), IL-1beta , and Tumor Necrosis Factor Alpha in Fibroblasts
Members of the NF-B/RelB family of transcription factors play important roles in the regulation of inflammatory and immune responses. RelB, a member of this family, has been characterized as a transcription activator and is involved in the constitutive NF-B activity in lymphoid tissues. However, in a previous study we observed an overexpression of chemokines in RelB-deficient fibroblasts. Here we ...
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Relb modulation of ib stability as a mechanism of transcription suppression of interleukin-1 (il-1), il-1, and tumor necrosis factor alpha in fibroblasts
Members of the NF-B/RelB family of transcription factors play important roles in the regulation of inflammatory and immune responses. RelB, a member of this family, has been characterized as a transcription activator and is involved in the constitutive NF-B activity in lymphoid tissues. However, in a previous study we observed an overexpression of chemokines in RelB-deficient fibroblasts. Here we ...
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Targeting Interleukin-6 Helps to Mitigate the Side Effects of Immunotherapy
Researchers at The University of Texas MD Anderson Cancer Center have identified a new strategy to reduce immune-related adverse events by targeting immunotherapy with the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell, provides evidence for the concept of combining immune checkpoint blockers and cytokine blockers to selectively inhibit inflammatory autoimmune responses. ...
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Regenerating Tissue with NovoSorb BTM
Unlike the body’s reparative healing response for deep wounds, which is chaotic, NovoSorb® BTM is unique in its ability to reorient the healing process from repair into regeneration. NovoSorb BTM is designed to promote the organized generation of a robust vascularized neodermis, designed to minimize scarring and contracture, thus improving functional and cosmetic patient outcomes. ...
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Exploring the Intricate Link Between Bile Acids and Disease
Bile acids are synthesized in the liver from cholesterol as a raw material. As a natural "emulsifier", they can promote the dissolution, digestion and absorption of fats, fat-soluble vitamins, etc. Meanwhile, as an important signaling molecule, bile acids can activate the relevant receptors to maintain the homeostasis of hepatic glucose and lipid metabolism, and interact with gut bacteria to ...
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Cell Transplantation Promising for Treatment of Biliary Diseases
Biliary disease is a term used to describe diseases that affect the biliary system, which can result in inflammation, fibrosis, bile duct destruction, and eventually liver failure. It also frequently leads to secondary infections and chronic irritation, such as bile duct stones, which can lead to malignant tumors. There is currently no cure for biliary tract diseases other than liver ...
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Rani Therapeutics offers breakthrough capsule for patients with chronic conditions
Rani Therapeutics offers a breakthrough capsule, the RaniPill which could change the way patients with chronic conditions take medication by eliminating the need for painful injections. Rani Therapeutics is a clinical-stage biotherapeutics company offering an alternative to painful injections for patients with chronic conditions such as neuroendocrine tumours(NETS). The company based in ...
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The Promoter of Life Evolution—Superoxide Dismutase
More and more scientific evidence shows that reactive oxygen species (ROS) and reactive nitrogen species are important mediators of signaling events in cells, especially the superoxide anion in reactive oxygen species. If the content of superoxide anion in the human body is too high, it may induce various diseases, including pro-inflammatory diseases (pro-inflammatory diseases), cardiovascular ...
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Cytokine Storms and Viral Infections
Cytokines are small soluble proteins that are secreted by immune cells and tissue cells to play a regulatory role between cells, including interferon (IFN), interleukin (IL), chemokines, colony-stimulating factors (CSF), tumor necrosis factors (TNF) and so on. Cytokines function in autocrine, paracrine or endocrine forms, and can regulate cell growth and differentiation, modulate immune response ...
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A Natural Polysaccharide-based Bioadhesive for Wound Repair Found
Hundreds of millions of people suffer skin tissue damage every year, including accidental injury, surgical injury, chronic ulcer, etc., and severe cases may lead to amputation or even life-threatening. Suturing is currently the preferred method for clinically closing wounds. However, wound suturing takes a long time during the operation, and removing the stitches will cause secondary damage to ...
By CD BioGlyco.
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What is FGL2?
Inflammation is a series of complex response events produced by the host system to pathogen infection and various tissue injuries. When the inflammatory response continues, it enters the stage of "uncontrollable inflammation", which plays an important role in the occurrence and development of complex diseases such as tumors. Therefore, the key molecular events in the process of ...
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Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
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How CBD benefits you with worst period problems
Rumor has it that even Queen Victoria sought CBD benefits for relief from menstrual cramps. And it’s no wonder, doctors have described period cramps as “painful as a heart attack” or “cutting your finger off without anesthesia.” Prostaglandins are the main reason why period cramps hurt. The body releases this hormone into the lining of the uterus to make the ...
By Relevium
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