injectable cell Articles
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Application of refractable nanocomposite on cell based therapy in central nervous system
Quantum Dots (QDs) are nano–particles carrying high stability fluorescence to follow the grafted cells which can be used in investigating the movement of cells and understanding the organogenesis of stem cells during development and wound repair processes in adulthood. For its easy acquirement and bypassing moral ethical issues, it makes the human adipose derived stem cells an attractive, ...
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Inhibition of the development of pulmonary tumour nodules and stimulation of the activity of NK cells and macrophages in mice by single low doses of low-LET radiation
As indicated by a few recent reports, exposures to low doses of ionising radiation can trigger the activity of natural anti-tumour defence mechanisms and impede the development of transplantable tumours in rodents. In our experimental system, BALB/c mice were irradiated with a single dose of 0.1, 0.2, 0.5, or 1.0 Gy X-rays and then i.v. injected with L1 sarcoma cells. As shown by the results of ...
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Bisphenol S alters embryonic viability, development, gallbladder size, and mRNA expression in chicken embryos exposed via egg injection
Amid concerns about the toxicological effects and environmental prevalence of bisphenol A (BPA), efforts to find suitable, safer replacement alternatives are essential. Bisphenol S (BPS) is one potential chemical substitute for BPA; however, few studies are available confirming it has a more desirable ecotoxicological profile. In the present study, BPS was injected into the air cell of ...
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CRISPR Screening Technology Brings More Versatility to High-Throughput Sequencing
Introduction to CRISPR Screen Sequencing CRISPR Screen technology is used for high-throughput screening, allowing a large number of gene mutant cells to be created and a mutant cell library to be screened in various external environments. The relationship between phenotype and genotype can be further evaluated using high-throughput sequencing and bioinformatics analysis. Furthermore, ...
By CD Genomics
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VetStem Cell Therapy Helps Senior Lab Walk Again
We absolutely love hearing stem cell success stories from pet owners. But some stories are extra touching because it’s clear that VetStem really improved a pet’s quality of life. That’s the case with Molly, a senior chocolate lab who was suffering from severe osteoarthritis and a potential spinal ...
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Diabetic Patient Receives Stem Cell Therapy
In a pioneering “off-the-shelf ” drug treatment in place of a surgical procedure, Maruti Hospital on Tuesday inaugurated its Regenerative Medicine Department by administering stem cell therapy for a diabetic patient who lost four toes on both feet. Developed by pharma major, Cipla, in collaboration with Bengaluru-based, Stempeutics Research, over 14 years, it is available (on order) ...
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Combatting the Opioid Crisis with Cell Therapies for Chronic Back Pain
It’s no secret that opioid addiction is at an all-time high and represents a major public health threat. The CDC estimates that opioid addiction resulted in a record 72,000 drug overdose deaths in 2017 alone. What strikes me as one of the most tragic parts of this narrative is that so many of these deaths were people who became addicted to opioids after simply seeking relief ...
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Science: Knockout of this epigenetic gene gives CAR-T cells the ability to continuously attack cancer cells
Simply put, CAR-T is to transform the patient's immune T cells in vitro by biotechnology, so that they recognize antigens on the surface of tumor cells, and then inject these cells back into the patient to achieve the therapeutic effect of recognizing and killing cancer cells. In 2017, CAR-T therapy was first approved by the FDA for the treatment of blood cancers such as leukemia and lymphoma. ...
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mRNA Delivery System
RNA is a hydrophilic, negatively charged macromolecule, and its ability to autonomously transmembrane is limited. Therefore, how to efficiently deliver mRNA to the cytoplasm and play a corresponding role is one of the key issues that limit the application of RNA therapy. The wide range of applications of therapeutic mRNA requires efficient and safe delivery methods. An ideal delivery system ...
By BOC Sciences
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Injecting mRNA and generating CAR-T directly in the body to repair the heart in one shot
January 6, 2022—Researchers at the Perelman School of Medicine at the University of Pennsylvania published a research paper in Science titled: CAR-T cells produced in vivo to treat cardiac injury. Heart damage or inflammation can induce fibroblasts to overproduce fibrous material, causing cardiac fibrosis, which hardens the heart muscle and impairs heart function. Heart failure, liver ...
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Curcumin loaded organically modified silica (ORMOSIL) nanoparticle; a novel agent for cancer therapy
Curcumin is a polyphenol compound extracted from the rhizome of turmeric (Curcuma longa) and has a well established anticancer property. However poor aqueous solubility is a major hindrance for its bioavailability and therapeutic use. Nanoparticle based system can be developed to overcome this problem. Present study has been undertaken with curcumin loaded organically modified silica (ORMOSIL) ...
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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A New Concept of Mosaicplasty: Autologous Osteoperiosteal Cylinder Graft Covered With Cellularized Scaffold
Abstract: A concern regarding osteochondral autograft transfer for chondral defects is donor-site morbidity of the knee, the most common source of the autograft. To avoid the drawbacks of osteochondral autograft transfer, a cylindrical osteoperiosteal graft harvested from the iliac crest covered by a same-sized cylinder of hyaluronic acidebased polymer scaffold pretreated with bone marrow ...
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RVx201 Herpes Vaccine
RVx201 Herpes Vaccine Description 2022 RVx201 is a first-in-human herpes simplex virus type 2 (HSV-2) live-attenuated therapeutic vaccine modified to be interferon sensitive that destroys the ability of the virus to inhibit immune responses. Produced by Rational Vaccines, Inc., the technology is based on the pioneering research of the late Dr. William Halford, who dedicated over 25 years to ...
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Research Progress on Aluminum Adjuvants and Their Mechanisms of Action
What are Adjuvants? Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. Adjuvants can help antigens induce long-term effective specific immune responses in vivo, leading to higher vaccine efficacy and prolonged protection from immune responses. ...
By BOC Sciences
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