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Intestinal Absorption Articles & Analysis

5 articles found

Understanding Caco-2 Permeability Assay: A Critical Tool for Drug Development

Understanding Caco-2 Permeability Assay: A Critical Tool for Drug Development

One of the most widely recognized in vitro models for evaluating the intestinal absorption of compounds is the Caco-2 permeability assay. This assay plays a pivotal role in understanding how drugs are absorbed in the gastrointestinal tract and aids in predicting their bioavailability. ...

ByCreative Bioarray


Understanding the MDCK Permeability Assay: A Key Tool in Drug Development

Understanding the MDCK Permeability Assay: A Key Tool in Drug Development

This assay utilizes Madin-Darby Canine Kidney (MDCK) cells, which are a widely used model for studying intestinal absorption and permeability due to their similarity to human epithelial cells. Importance of the MDCK Permeability Assay Drug absorption in the gastrointestinal tract is a significant factor that influences the efficacy of oral ...

ByCreative Bioarray


Recapitulating the Multifaceted Inflammatory Environment of the Intestine In Vitro

Recapitulating the Multifaceted Inflammatory Environment of the Intestine In Vitro

Differences in intestinal physiology may cause differences between UC and CD, as the different regions within the small intestine and colon, as well as differences in the two tissues themselves, are vast. ...

ByAltis Biosystems


Novel nanoplatform for oral delivery of anti–cancer biomacromolecules

Novel nanoplatform for oral delivery of anti–cancer biomacromolecules

These NC were loaded with multi functional anti cancer bovine lactoferrin (Lf), a natural milk based protein, for improvement of intestinal absorption, in order to develop a novel platform to carry anti cancer protein and/or peptides for oral therapy. ...

ByInderscience Publishers


Effects of nickel exposure and acute pesticide intoxication on acetylcholinesterase, catalase and glutathione S-transferase activity and glucose absorption in the digestive tract of Helix aspersa (Pulmonata, Helicidae)

Effects of nickel exposure and acute pesticide intoxication on acetylcholinesterase, catalase and glutathione S-transferase activity and glucose absorption in the digestive tract of Helix aspersa (Pulmonata, Helicidae)

The activity of detoxifying enzymes and glucose absorption were measured in the digestive tract of Helix aspersa exposed to nickel. Nickel decreased CAT activity and, in the lower concentration, inhibited intestinal absorption of glucose. Elevated AChE activity and unchanged GST activity indicate diversity in enzymatic response to nickel. ...

ByInderscience Publishers

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