intravenous administration Articles
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Nanobiotechnology approaches for targeted delivery of pharmaceutics and cosmetics ingredients
Nanobiotechnology refers to the ability to create and manipulate biological and bio-chemical materials, devices, and systems at atomic and molecular levels. Nano delivery systems hold great potential to overcome some of the obstacles in bio-pharmaceutical production, such as water soluble/insoluble pharmaceutical drugs and cosmetic ingredients, risks of toxicity, increasing bio-active efficacy, ...
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Vanadium Distribution Following Decavanadate Administration
Abstract An acute exposure of two vanadate solutions—metavanadate and decavanadate—containing different vanadate oligomers, induces different patterns of subcellular vanadium distribution in blood plasma, red blood cells (RBC), and cardiac muscle subcellular fractions of the fish Sparus aurata (gilthead seabream). The highest amount of vanadium was found in blood plasma 1 h after (5 mM) ...
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Rani Therapeutics prices $73M IPO for robotic drug-delivery pill tech
Rani Therapeutics Holdings (NSDQ:RANI), developer of a robotic drug-delivery pill system, generated $73.3 million in its underwritten initial public offering (IPO) of Class A common stock. The San Jose, Calif.–based company’s IPO of 6.7 million shares priced at $11 a share, generating gross proceeds of $73.3 million. The company initially targeted an IPO worth approximately $100 ...
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Antibody Drug Conjugates: "Biological Missiles" For Targeting Cancer Therapy
Antibody-drug conjugates (ADCs) usually consist of monoclonal antibodies (mAbs) covalently linked to cytotoxic drugs via chemical linkers. With high specific targeting ability and strong killing effect, it has achieved precise and efficient removal of cancer cells, and has become one of the hot spots in the development of anticancer drugs. In 2000, the FDA first approved the ADC drug Mylotarg ...
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The Reality and Future of Peptide Drugs
It has been said that the 21st century is the century of peptide drugs, and the fate of this substance, which lies between a large protein and a small molecule compound, is bound to be extraordinary. What are peptide drugs? Peptides are a class of compounds made up of amino acids linked by peptide bonds and are chemically active substances commonly found in living organisms. According to the ...
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Project - Sublingual Interferon-alfa (BL SLIT II)
We plan to develop sublingual interferon-alfa for the prevention of viral infections, such as influenza and coronaviruses (such as COVID-19). The rise in prevalence of viral respiratory infections in humans and increase in health care expenditure are projected to boost the growth of the global respiratory antiviral treatment market. Respiratory syncytial virus, influenza virus, parainfluenza ...
By BioLingus AG
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Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning
A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, multiplexing and sequencing technologies have accelerated engineering of improved capsid properties such as production yield, packaging efficiency, ...
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G Protein-Coupled Receptors targeted by antibodies raised against three dimensional epitopes
Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in ...
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Nebulised MSC-Derived EVs: A Potential Therapy for E. coli-Induced Pneumonia
Mesenchymal stem cells (MSCs) have shown great promise in cell therapy for various diseases, including lung injury. However, recent research has focused on the therapeutic potential of extracellular vesicles (EVs) derived from MSCs. These EVs contain bioactive molecules that can modulate immune responses and promote tissue repair. In the context of pneumonia caused by Escherichia coli (E. coli) ...
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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Seven technologies to watch in 2022
Our fifth annual round-up of the tools that look set to shake up science this year. From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead. Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers Karen Miga at the University of ...
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