Intravenous Administration Articles & Analysis
9 articles found
Why target GPCRs with antibodies? The G Protein-coupled receptor (GPCR) superfamily represents the largest and single most important family of human drug targets. GPCRs play a central role in a plethora of biological processes and are linked to a wide range of therapeutic areas including cancer, diabetes, inflammation, cardiovascular diseases, and chronic pain. Expressed in every type of cell in ...
The first is that it usually requires parenteral administration (e.g. intravenous injection). The second is that such treatment is frequently associated with significant systemic side effects that limit their tolerability to patients. ...
Representative Small Molecule Payloads in ADC Drugs After intravenous administration, about 2% of ADCs reach the target tumor site and need to be highly effective as payloads in ADCs (IC50s need to be in the nanomolar and picomolar classes). ...
Dosage form of peptide drug Due to the physical and chemical properties of peptides, most of them are injectables, which can be used for intravenous injection or intravenous drip, and their main types of formulation are lyophilised powders. In recent years, in addition to the classical subcutaneous, intramuscular and intravenous ...
The company has developed a proprietary platform designed to provide a pill-based alternative to intravenous or subcutaneous administration of biologics. The robotic pill deploys its payload of proteins, peptides or antibodies when it reaches the intestine. ...
As natural selection did not optimize such capsids for therapeutic use, they display limited specificity of cell targeting and low overall in vivotransduction efficiency in many target tissues, particularly following intravenous administration. Improving in vivotransduction of target cells and organs would enable gene therapies to more effectively treat diseases, ...
In this study, a physiological-based mathematical model was developed to describe and compare the absorption, distribution, metabolism, and elimination (ADME) of nanoparticles after intravenous (IV), oral, and pulmonary exposure. The development of the model was based on physiological principles, compartmental analysis, and mathematical modelling. ...
Within nanoparticulate carriers, polymeric and lipid nanoparticles have risen to the forefront of bio-technology, having diverse applications in several fields of pharmaceuticals for oral, topical, ocular and intravenous administration, as well as in dermo-cosmetic products.Keywords: nanobiotechnology, polymeric nanoparticles, lipid nanoparticles, delivery ...
The highest amount of vanadium was found in blood plasma 1 h after (5 mM) intravenous vanadate administration (295 ± 64 and 383 ± 104 μg V/g dry tissue, for metavanadate and decavanadate solutions, respectively), being 80-fold higher than in RBC. After 12 h of administration, the amount of vanadium in plasma, as well as in cardiac cytosol, ...