kidney injury Articles
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Cardiovascular Consequences of Acute Kidney Injury
Annotations Acute kidney injury (AKI) is recognized as a potential risk factor for future cardiovascular events, especially heart failure. Up to 60% of patients with severe AKI who are admitted to an intensive care unit (ICU) die; the long-term risk of death associated with AKI is also increased. Preclinical models and biomarkers have identified several likely pathways, apparently involving ...
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Galectin-3 in septic acute kidney injury: a translational study
Abstract Background: Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3's role and its potential utility as a therapeutic target in S-AKI. Methods: In 57 patients admitted to the intensive care unit (ICU) with ...
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Elevated Preoperative Galectin-3 Is Associated With Acute Kidney Injury After Cardiac Surgery
Annotations Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft surgery and/or valve. Patients in the highest third of Gal-3 levels had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the lowest third. Elevated preoperative Gal-3 levels significantly ...
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3 Things That Google’s Healthcare Artificial Intelligence Desperately Needs
Google DeepMind recently published a paper in Nature that shared how their predictive algorithm can detect Acute Kidney Injury (AKI) up to 48 hours in advance. Acute Kidney Injury is the biggest problem you have never heard of. In the US, 1 in 5 hospitalized adults gets Acute Kidney Injury, resulting in a 5x risk of death. It takes the lives of over 300,000 Americans every year. Globally, the ...
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Map of the Month - April
Welcome to Edinburgh Instruments newest blog celebrating our work in Raman, Photoluminescence, and Fluorescence Lifetime Imaging. Every month we will highlight our pick for Map of the Month to show how our spectrometers can be used to reveal all the hidden secrets in your samples. April Studying animal tissue is an important tool for scientists to learn more about the effects of treatments for ...
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A translational study of Galectin-3 as an early biomarker and potential therapeutic target for ischemic-reperfusion induced acute kidney injury
Abstract Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI. Methods: Among fifty-two post-cardiac surgery patients, serum and urine Gal-3 levels were examined on intensive care unit (ICU) admission. In a rat renal I/R ...
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The Use of Imaging to Guide Treatment Decisions with Coronary Orbital Atherectomy – Case 2 of 2
Overview Dr. Brock Cookman describes this real-world case to demonstrate the importance of imaging to determine strategy and treatment in complex scenarios and how the unique dual-action mechanism of action (MOA) of the Diamondback 360® Coronary Orbital Atherectomy System sands superficial and fractures deep calcium. Patient History A 78-year-old female patient presented with ...
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Urine Output Monitoring Shows Better Outcomes, Better Data for COVID-19 Frontline Workers - Case study
Clinical Case Study: Grady Health, Atlanta, GA. A Case study, utilizing a novel remote monitoring tablet, directly connected to the Accuryn Monitoring System. Background: There are an estimated 300,000 deaths from acute kidney injury (AKI) annually in the U.S.1 A mountain of growing clinical literature has shown that hourly urine output (UO) monitoring may lead to earlier recognition of AKI ...
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On a Mission to ZERO False-Positive Blood Cultures
Improve sepsis testing accuracy. Enhance patient safety. These are the driving forces behind Magnolia Medical Technology’s Mission to ZERO. Mission to ZERO™ is a nationwide plan to create greater awareness of patient safety and antibiotic-associated risks caused by false-positive diagnostic test results for sepsis. The goal is to initiate change by improving national blood culture ...
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Galectin 3 Inhibition Attenuates Renal Injury Progression in Cisplatin-Induced Nephrotoxicity
Annotations Kidney toxicity is a significant side-effect withGal-3 plays an essential role in kidney fibrosis and renal failure, and it is one of the critical factors for renal injury Inhibition of Gal-3, mediated by MCP, antagonized the pro-apoptotic (cell death) effects. MCP- treated mice demonstrated increased renal function and reduced renal fibrosis after cisplatin- induced MCP-treated ...
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Biochemical and histopathological alterations in kidney of rats chronically exposed to mild silver protein
Chronic administration to Wistar rats of Mild Silver Protein (MSP) to a dose of 222 mg Ag/kg/day in the drinking water for six months showed that the MSP produces argyria, with histopathological lesions in the kidney, the organ where silver accumulates. The histopathology of the kidney showed capillary damage, with alteration of the vascular wall, increased perivascular cellularity and area with ...
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Cytokine Involvement in Inflammatory Immune Disorders
Cytokines, small molecules with potent biological activity, are primarily synthesized by immune and non-immune cells (e.g., vascular endothelial cells, epidermal cells, fibroblasts) in response to stimulation. These signaling molecules form intricate networks that contribute to immune responses, inflammatory reactions, cell proliferation, and growth. Cytokine Dysregulation in Systemic Immune ...
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Will Metformin Be Replaced By SGLT-2 Inhibitors
Metformin is a classic first-line hypoglycemic agent for patients with type 2 diabetes, and is an essential drug in combination regimenes. However, as the evidence is updated, the idea of drug selection for first-line treatment is changing. GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin (as required for glycemic management) have also been recommended by multiple ...
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Protein Quantification Techniques and Their Application in Clinical Research
Representing the expression, post-translational modification, and protein-protein interaction for certain cells, tissues, or organs, proteomics has become an increasingly important means to understand the molecular mechanism and signal transduction of human disease and cancer. Protein levels in the body are in a steady state of equilibrium. Accumulation of proteins usually leads to qualitative ...
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Bladder management practice for spinal cord injury patients
The spinal cord is to relay messages between the brain and the rest of the boy. When spinal cord injury happens the body may lose some essential functions if the nerves can’t communicate with the brain. Inadequate bladder management of spinal cord injury (SCI) results in medical complications, psychological stress and even mortality. Frequent leakage of urine causes soiling of clothes ...
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Health and Safety in Heavy Industries
Many vapours and gases found in heavy industries pose an explosion risk. For any gas to combust it must reach its lower explosive limit (LELs). Lower explosive limits have been well established for 100s of chemicals and generally vapours from VOCs have relatively low explosion limits. For example, methane and hydrogen have LELs of 50,000 ppm and 40,000 ppm respectively whereas benzene has ...
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What Aae Toxins and How do they Impact your Health?
Toxins are everywhere—from the air we breathe and the food we eat, to the water we drink and the products we use. But what are toxins exactly? A toxin is a naturally occurring substance that can act as a poison to living things. While small doses may not trigger a reaction, large amounts or exposure over an extended period of time can be detrimental to your health. But what are ...
By Evidation
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Research Progress of Tetrahydrocurcumin
Tetrahydrocurcumin (THC), as the most active and main metabolite produced in the metabolism of curcumin in vivo, can be isolated from the cytoplasm of the small intestine and liver after curcumin administration in human or mouse. Tetrahydrocurcumin can effectively inhibit tyrosinase, inhibit the generation of Oxygen Free Radicals and scavenge the formed free radicals. It has obvious antioxidant ...
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Antacids, Prescription Drugs or Digestive Enzymes? Your Best Bet for Better Digestion
Upset stomach, heartburn, diarrhea? There are few symptoms as disruptive to your daily life as ones that originate in the digestive system. And if you’re struggling with any of these symptoms, you know exactly how difficult they are to get rid of for good. Doctors recommend a variety of treatments, but there are three biggies they suggest most often for patients who are dealing with both ...
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Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease
Follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg — dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering ...
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