leukemia Articles
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Infrared spectroscopy of human bone marrow: evidence of structural changes during acute leukemia
Fourier transform infrared (FTIR) spectroscopy was explored as a means to distinguish newly diagnosed of acute lymphoblastic leukemia from disease free bone marrow samples. Characteristic bands alterations were identified in both healthy and diseased samples arising from cellular protein, lipid and DNA. There were specific changes that affected the secondary structure of proteins that appeared in ...
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Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex
Approximately 10% of cancers overall use alternative lengthening of telomeres (ALT) instead of telomerase to prevent telomere shortening, and ALT is especially common in astrocytomas and various types of sarcomas. The hallmarks of ALT in telomerase-negative cancer cells include a unique pattern of telomere length heterogeneity, rapid changes in individual telomere lengths, and the presence of ...
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Identification of a posttranslational mechanism for the regulation of herg1 k+ channel expression and herg1 current density in tumor cells
A common feature of tumor cells is the aberrant expression of ion channels on their plasma membrane. The molecular mechanisms regulating ion channel expression in cancer cells are still poorly known. K+ channels that belong to the human ether-a-go-go-related gene 1 (herg1) family are frequently misexpressed in cancer cells compared to their healthy counterparts. We describe here a ...
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What is the meaning of neoplastic disease?
Neoplasia is the abnormal growth and proliferation of abnormal cells or abnormal amounts of cells due to a benign or malignant process. There can be benign tumors, or neoplasms, and malignant ones. Remember that it's the malignant tumors, or cancer, that can metastasize, which is when cancer spreads around the body. Leukemia is used for lymphoid neoplasms presenting with widespread involvement ...
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Inhibition of apoptosome formation by suppression of hsp90β phosphorylation in tyrosine kinase-induced leukemias
Constitutively active tyrosine kinases promote leukemogenesis by increasing cell proliferation and inhibiting apoptosis. However, mechanisms underlying apoptotic inhibition have not been fully elucidated. In many settings, apoptosis occurs by mitochondrial cytochrome c release, which nucleates the Apaf-1/caspase-9 apoptosome. Here we report that the leukemogenic kinases, Bcr-Abl, FLT3/D835Y, and ...
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Tackling Barriers to MRD Adoption in the Community Setting
The day a person receives a cancer diagnosis is likely one of the worst days of their lives. For some new patients, the typical approach may be to seek care from a specialist at an NCCN-designated cancer center. But for the majority of Americans, it will be a community oncologist who guides them through their cancer journey. That’s why Adaptive recently partnered as a sponsor with ...
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Natural killer cell reprogramming with chimeric immune receptors
Abstract Natural killer (NK) cells are emerging as a new tool for cell therapy of cancer. However, some cancer subtypes are relatively resistant to NK cell cytotoxicity. Expression of anti-CD19 chimeric signaling receptors can enhance NK-cell reactivity against CD19+ leukemia and lymphoma cells. Here we describe a method to enforce expression of such receptors in human NK cells relying on ...
By Nkarta, Inc.
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The Problem with Gene-Modified Cell Therapy Manufacturing
Gene-modified cell therapies (GMCTs) represent the most effective therapeutic platform for many patients with advanced diseases including relapsed and refractory leukemia, non-Hodgkin lymphoma, and other blood cancers [1]. Specifically, chimeric antigen receptor T cell (CAR-T) therapies targeting CD19 have demonstrated remarkable responses and possibly cures in patients with advanced acute ...
By Indee Labs
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Upgrades to Our Cancer Model Database - Case Study
We've added over 125 new datasets to our Cancer Model Database. It provides access to a comprehensive collection of well-established tumor models for early-stage oncology research and increases their translational capabilities to the clinic. The update adds new patient-derived xenograft (PDX) models for several cancer types, including anal, colon, kidney, renal, and leukemia. Additionally, this ...
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Overview Of SFA Therapeutics
SFA Therapeutics’ CEO Dr Ira Spector presents an overview of the company and its platform technology SFA Overview Presentation on YouTube Introduction to SFA Liver Disease and Oncology Programs. SFA Oncology More information here We received US Patent 10,143,669B2; to prevent Hepatitis B progression to HCC, a liver cancer that affects 400 million patients and causes 1 million cancer ...
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Near-atomic-level Details of Cancer Proteins with the Help of Molecular Cages Revealed
Sandwiching the wobble protein between two other layers allowed scientists to get the most detailed picture of a protein that is key to the spread of acute myeloid leukemia. Acute myeloid leukemia (AML) afflicts more than 20,000 Americans each year, killing more than 11,000 of them, according to the American Cancer Institute. And many people who receive intensive chemotherapy or stem cell ...
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Enabling Genomics in Practice
There are certain times in your life where a single sentence can change your life’s trajectory. My sentence was, “Theo has leukemia.” For anyone who has experienced it, they know far too well that cancer spares no one. While the warriors like my nephew bravely battle, it uproots entire families. Time is divided between hospital and home, and normalcy no longer exists. ...
By PierianDx
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A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia (Clinical Cancer Research)
Purpose:Although considerable progress has been made withautologous T cell–based therapy in B-cell malignancies, appli-cation in chronic lymphocytic leukemia (CLL) lags behind dueto disappointing response rates as well as substantial toxicitythat is of particular concern in the elderly CLL population.Vg9Vd2-T cells form a conserved T-cell subset with strongintrinsic immunotherapeutic ...
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Bioimpedance spinal needle provides high success and low complication rate in lumbar punctures of pediatric patients with acute lymphoblastic leukemia
The great results of our latest clinical investigation have now been published as an open access article in Scientific Reports, a respected peer-review journal. Read the article from the journal using the link! Bioimpedance spinal needle provides high success and low complication rate in lumbar punctures of pediatric patients with acute lymphoblastic leukemia. 2022 April 26 Tampere University ...
By Injeq Oy
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Re-examining the health effects of radiation and its protection
The health effects of radiation from atomic explosions in Japan were completely different from those due to radiation from the Co-60 contaminated apartments in Taiwan. The sudden exposure to acute radiation in extremely high doses killed Japanese people, and harmed the survivors in lower doses as shown by increased cancer mortality, especially the leukemia based on the LNT model. The chronic ...
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Employee Spotlight: Dr. Gerald Martin
Understanding the human genome has opened up incredible new possibilities for health. As experts in this complex field, we lead the way in bringing genomic insights into patient care so communities anywhere can benefit. Our employee spotlight shines the light on Gerald Martin, Senior Field Application Scientist. What is your educational background? I have a BA Honours degree from Trinity ...
By PierianDx
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Protein Acetylation and Ubiquitination Interactions Control MCL1 Protein Stability
The anti-apoptotic myeloid cell leukemia 1 (MCL1) protein belongs to the BCL2 family that supports survival and is frequently amplified or upregulated in human cancers. MCL1 is highly unstable and its stability is regulated by phosphorylation and ubiquitination. Here, the authors suggest that acetylation is another key post-translational modification that regulates MCL1 protein instability. The ...
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Tracking disease clusters and environmental health
On March 29, the U.S. Senate Committee on Environment and Public Works held a hearing entitled “Oversight Hearing on Disease Clusters and Environmental Health.” Committee Chairwoman Barbara Boxer, D-Calif., and Senator Mike Crapo, R-Idaho, ranking member of the Superfund, Toxics and Environmental Health Subcommittee, introduced the Strengthening Protections for Children and ...
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Cancer incidence in areas with elevated levels of natural radiation
It has been reported that on reaching a certain level of cell damage the production of repair enzymes is triggered which decreases the chromosome aberrations. If this happens, prolonged exposure to high levels of natural radiation in areas with elevated levels of background radiation could decrease the frequency of chromosome aberrations. Recent epidemiological studies indicated that there is an ...
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The 3rd AIDS patient is "cured"! Has mankind finally conquered AIDS?
At an academic conference on Feb 15, U.S. experts announced the world's first female AIDS "cure," making it the third case of HIV infection to be cured. After therapy and withdrawal of antiviral drugs, HIVs were not identified in the patient's body for more than 14 months, indicating that the virus was in complete remission, according to academics. The key to this patient's recovery was a blood ...
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