liver fibrosis Articles
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MRE associated with increased risk of cardiovascular disease in patients with NAFLD - Case study
A new study was published in March of 2021 demonstrating that elevated liver stiffness, as measured by magnetic resonance elastography (MRE), is associated with higher rates of cardiovascular disease in patients with non-alcoholic fatty liver disease (NAFLD). As clinical researchers, regulators and pharmaceutical partners pursue noninvasive biomarkers to replace liver biopsy, links to adverse ...
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Changes in MRE in HCV patients who achieve SVR
Abstract Almost all patients achieved sustained virological response (SVR) by direct-acting antivirals (DAA) therapy, but it is not clear as to what extent DAA therapy affects changes in liver fibrosis after achieving SVR. In this study, we investigated the changes of liver stiffness by magnetic resonance elastogaraphy (MRE) during DAA therapy. A total of 308 patients were enrolled in the study. ...
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The Role of Probiotics in Cancer Prevention Receives Increasing Attention
Liver cancer is the fifth most common cancer in the world and the third leading cause of cancer deaths. A healthy diet and lifestyle are the key to preventing various diseases. In recent years, probiotics, as part of a healthy diet, have received increasing attention for their role in cancer prevention and treatment, including liver cancer. Do probiotics have the potential to prevent liver ...
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Utilization of a 3D bioprinted liver tissue model to evaluate the antifibrotic effects of an ALK5 inhibitor in a TGFß-induced model of hepatic fibrosis
Publication Summary: Compound induced chronic liver injury can lead to initiation of profibrotic processes resulting in sustained production of growth factors and profibrotic cytokines where inflammation, tissue remodeling and repair pathways are activated simultaneously to counteract the injury. Evaluation of potential antifibrotic therapies are limited using conventional non-human animal ...
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Cell Transplantation Promising for Treatment of Biliary Diseases
Biliary disease is a term used to describe diseases that affect the biliary system, which can result in inflammation, fibrosis, bile duct destruction, and eventually liver failure. It also frequently leads to secondary infections and chronic irritation, such as bile duct stones, which can lead to malignant tumors. There is currently no cure for biliary tract diseases other than liver ...
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Improved 3D Liver Model Could Forever Change Drug Testing – Allevi Author
The liver plays an incredibly important role in the human body by metabolizing drugs and other compounds. Developing accurate in vitro liver models to study is a critical step in better understanding the biological dynamics of our bodies and removing our dependence on animal models. In their recent publication, Allevi authors Marie Cuvellier, Frédéric Ezan, Hugo Oliveira, Sophie ...
By Allevi, Inc.
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...
By KoBioLabs
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Overview Of SFA Therapeutics
SFA Therapeutics’ CEO Dr Ira Spector presents an overview of the company and its platform technology SFA Overview Presentation on YouTube Introduction to SFA Liver Disease and Oncology Programs. SFA Oncology More information here We received US Patent 10,143,669B2; to prevent Hepatitis B progression to HCC, a liver cancer that affects 400 million patients and causes 1 million cancer ...
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Liver function assessment in workers exposed to vinyl chloride
Objective: To investigate liver function in vinyl chloride workers and assess its relation with current/past occupational exposure to vinyl chloride monomer (VCM). Methods: A medical examination including the execution of liver function tests (LFTs) and liver ultrasonography was executed in a group of 757 workers with a long-standing service in the production of VCM/polyvinylchloride (PVC). ...
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Degradation of splicing factor SRSF3 contributes to progressive liver disease
Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), ...
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