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Liver Metabolism Articles & Analysis

8 articles found

Understanding ADME Testing Services: A Key Component in Drug Development

Understanding ADME Testing Services: A Key Component in Drug Development

ADME stands for Absorption, Distribution, Metabolism, and Excretion, which are critical processes that determine the fate of a drug within the body. ...

ByCreative Bioarray


Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

Pharmacokinetic Characteristics of Monoclonal Antibody Drugs

Pharmacokinetic characteristics are composed of and determined by drug absorption, distribution, metabolism and excretion. The structure, physiological properties and pharmacokinetic characteristics of monoclonal antibodies are different from those of traditional small molecule drugs. ...

ByCreative Proteomics


Function and Detection of Bile Acids

Function and Detection of Bile Acids

Bile acids are the main components of bile and are synthesized in the liver from cholesterol through a series of enzymatic reactions. Bile acids can be divided into free bile acids and conjugated bile acids according to their structures. ...

ByCreative Proteomics


Exercise in the morning or in the evening has a completely distinct effect!   

Exercise in the morning or in the evening has a completely distinct effect!  

They discovered that following early morning exercise, the liver demonstrated a considerable fatty acid metabolic response, with selective increases in fatty acid metabolites. ...

ByCreative Biolabs


Algatech Triples FucoVital Production Capacity

Algatech Triples FucoVital Production Capacity

This wonder ingredient can help support two of the most important health concerns in the world, liver health and metabolic function" says Hagai Stadler, CEO of Algatech. Liver health is one of the most serious modern health issues todayfll. ...

ByAlgatech


Degradation of splicing factor SRSF3 contributes to progressive liver disease

Degradation of splicing factor SRSF3 contributes to progressive liver disease

Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. ...

ByJohnson Controls, Inc.


Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae

Lethal and sublethal effects of phthalate diesters in Silurana tropicalis larvae

Parametric analysis of gene set enrichment revealed an important increase in the expression of genes related to drug metabolism and transport, liver metabolism, xenobiotic clearance, and xenobiotic metabolism after DMP and DCHP treatments, while these responses were less pronounced with MMP (the metabolite of DMP). ...

ByJohn Wiley & Sons, Ltd.


CYP‐mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species; in vitro assays in several birds and in vivo assays in chicken

CYP‐mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species; in vitro assays in several birds and in vivo assays in chicken

We previously reported substantial differences in WF metabolism among avian species, however the actual in vivo pharmacokinetics have yet to be elucidated, even in the chicken. In the present study, we sought to provide an in‐depth characterization of WF metabolism in birds using in vivo and in vitro approaches. We performed a kinetic analysis of WF ...

ByJohn Wiley & Sons, Ltd.

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