lung cell Articles
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Nanomechanics of lung epithelial cells
Nanobiotechnology provides powerful tools for manipulating cells with nanometric resolution and with simultaneous measurement of force with pN resolution. We review the application of atomic force microscopy (AFM) and magnetic tweezers for probing cell nanomechanics. AFM measures the mechanical properties of the cell by indenting its surface by means of a flexible cantilever with a sharp tip at ...
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Demonstration of radiation-induced bystander effect in a human lung cancer cell line
The purpose of this study was to investigate whether a bystander effect is manifested in a large cell lung tumoural cell line (QU-DB). For induction of a bystander effect in non-irradiated cells the 'medium transfer' technique was employed, and to observe the effect the cytokinesis-block micronucleus assay was applied. Results showed that irradiated and bystander cells demonstrated higher numbers ...
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Fabrication And Characterization Of 3D Bioprinted Triple-Layered Human Alveolar Lung Models
Researchers from Nanyang Technological University and its Center for 3D printing (SC3DP) have developed a 3D printed a highly repeatable and scalable three-dimensional in-vitro alveolar lung model using our REGENHU bioprinter, that could be exploited for pathogen translocation studies and respiratory-related toxicological testing applications. The triple-cell layered lung model was realized ...
By Regenhu
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Poly(propyleneimine) dendrimers as potential siRNA delivery nanocarrier: from structure to function
The goal of the present investigation is to reveal the role of the Poly(propyleneimine) (PPI) dendrimer structure on the siRNA nanoparticles formation, facilitation of cell internalisation, and sequence specific knockdown of targeted genes. It was found that the higher generations of PPI dendrimers (G4 and G5) most effectively initiated the complexation of siRNA into discrete nanoparticles when ...
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Increased expression of genes in a radioresistant cell strain: modulation of hnRNP E2, Hsp90 and SSBP2 genes in γ-irradiated Chinese hamster V79 cells
The methotrexate-resistant cell strain M5, derived from Chinese hamster lung fibroblast cell line V79, provides a good model to study differential gene expression in response to stress. Genes coding for human homologues of myosin phosphatase (AF458589), filamin-like protein (AAA92644), phosphate transporter 1 (AAH199441) and hnRNP E2 (NP_035172.1) were upregulated in M5 as determined by RAP-PCR. ...
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Improving drug loading efficiency and delivery performance of micro– and nanoparticle preparations through optimising formulation variables
In this report, we briefly introduce our recent studies related to drug delivery systems using biodegradable materials, PLGA, PLA or chitosan to prepare submicroparticles or microparticles for carrying vaccine, protein or small molecule drugs. These preparations were prepared by spray dried or solvent extraction methods. In addition, liposomal formulations containing various lipids and pegylated ...
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Microfluidic tools to investigate pathologies in the blood microcirculation
We show how microfluidics technology can be used to fabricate simple and innovative biomimetic tools to shed new light on physiopathological events occurring in the blood microcirculation. Examples of applications are given in the context of the acute respiratory distress syndrome (ARDS), an inflammatory disease of the lung triggered by a massive arrest of white blood cells in the lung ...
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The Potential of WNT/B-Catenin Modulation in Treating Pulmonary Fibrosis
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF), represents a significant challenge in healthcare due to its detrimental impact on lung function and limited treatment options. While WNT/β-catenin signaling plays a crucial role in lung development and maintenance of adult lung stem cells, its dysregulation has been associated with pulmonary fibrosis. However, recent ...
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Scientists use lipid nanoparticles to precisely target gene-editing tools to the lung
Safe and effective systemic delivery of mRNA to specific organs and cells in vivo remains a major challenge in the development of mRNA-based therapies. Currently, the application of mRNA-based technologies is largely limited to liver diseases because of the lack of specific and effective extrahepatic systemic mRNA delivery systems in vivo. Now, a team of researchers has fine-tuned the existing ...
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New structural target against COVID-19
A new structural target for drug development against COVID-19 has been unveiled today by Sibylla Biotech in collaboration with the Italian National Institute of Nuclear Physics (INFN), the University of Trento and University of Perugia.The breakthrough drug discovery strategy pioneered by Sibylla in this study would not only promise to reduce the risk of drug resistance and harmful side effects, ...
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Paclitaxel Injection Market to Grow at Stable CAGR of 12.8% from 2023 to 2032
Global Paclitaxel Injection market document provides actionable industry insights with which sustainable, valuable, and money-spinning business strategies can be created. All the information, facts, and statistics covered in the report lead to actionable ideas, improved decision-making and better-deciding business strategies. With the complete knowledge of business goals and needs to bridge the ...
By insightSLICE
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Bioaccesible heavy metals‐sediment particles from Reconquista River induce lung inflammation in mice
The Reconquista River (RR), one of the most polluted watercourses in Argentina, receives effluent discharges from heavily industrialized and highly populated settlements. During winter and summer, the floodplain remains dry, producing the oxidation of sulfide and organic matter present in the sediment, making heavy metals more bio‐accessible. Dispersion of this sediment occurs, and thus harmful ...
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Effect of interferon receptor pathway on CAR-T cell-mediated killing of solid tumors
Researchers at Massachusetts General Hospital (MGH) have found that interferon gamma receptor (IFNgR) signaling is essential for the susceptibility of CAR-T cell immunotherapy to kill malignant gliomas. The same phenomenon has been observed in other solid tumors. The findings may partially explain why liquid and solid tumors respond very differently to CAR-T cell therapy. Chimeric antigen ...
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Comparison of genomic signatures of non-small cell lung cancer recurrence between two microarray platforms
Abstract Background Cancer genomic signatures may vary using different platforms. We compared the differential gene expression in non-small cell lung cancer (NSCLC) between two platforms in order to find the most relevant genomic signatures of tumor recurrence. Materials and Methods We analyzed gene expression in frozen lung cancer tissue from 59 selected patients who had undergone surgical ...
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A new model using artificial intelligence to predict recurrence after surgical resection of stage I-II non-small cell lung cancer.
Abstract Background: Five-year survival for stage I-II lung cancer is quite low even after complete surgical resection. Current guidelines recommend adjuvant treatment only for selected patients with stage II or higher disease. A prediction model that identifies patients at high risk of recurrence who may benefit from adjuvant treatment is greatly needed. Many existing prediction models include ...
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Tumor Glycan-Targeted Therapy
Glycosylation is a sophisticated type of post-translational modification that impacts over 50% of cellular proteins and is a critical regulator of many eukaryotic processes. Aberrant glycosylation is a common hallmark of many malignancies and is important at all stages of tumor growth. Glycosylation regulates a range of physiopathological processes, including cell-cell adhesion, cell-matrix ...
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Gene Therapy for Cystic Fibrosis
What is cystic fibrosis? Cystic fibrosis (CF) is a rare genetic disorder that affects the lungs, digestive system, and other organs. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a protein that regulates chloride ions transport across cell membranes. These mutations cause the CFTR protein to be either absent or not function ...
By Protheragen
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What are the Possibilities for ADCs Targeting Trop2?
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is associated with the occurrence of many tumors and poor prognosis. It is a very popular ADC research target, second only to HER2. Currently, only Gilead's Trop-2 ADC drug Trodelvy has been approved for ...
By BOC Sciences
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FDA Approved ALK Inhibitors for ALK-Positive Non-Small Cell Lung Cancer
Lung cancer is a major type of cancer in the world, with the highest morbidity and mortality among all malignant tumors. ALK-positive non-small cell lung cancer (ALK+ NSCLC) is a relatively rare and dangerous subtype, with patients suffering from a high incidence rate of brain metastases. Statistics show that about 55% of ALK-positive advanced NSCLC patients will develop brain metastases during ...
By BOC Sciences
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Spanish Cancer Company Universal Dx to Commercialize Methylation Method for Lung Cancer Detection
NEW YORK - Spanish cancer research firm Universal Diagnostics is gearing up to commercialize a liquid biopsy test that applies methylation biomarkers to detect lung cancer, based on data presented at the International Association for the Study of Lung Cancer 2020 World Conference for Lung Cancer (WCLC) last month. The Seville-based firm also expects to release clinical data on its next ...
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