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Lung Epithelial Articles & Analysis

5 articles found

Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2

Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2

Until today, influenza A virus (IAV) poses a great threat to human health having caused several pandemics with high mortality, e.g., the Spanish flu in 1918, the Asian flu in 1957, and the swine flu pandemic in 2009 (Taubenberger and Morens, 2006; Dawood et al., 2012; Viboud et al., 2016). IAV infects epithelial cells by binding with its hemagglutinin (HA) spikes to sialic acid ...

ByAtriva Therapeutics GmbH


Fabrication And Characterization Of 3D Bioprinted Triple-Layered Human Alveolar Lung Models

Fabrication And Characterization Of 3D Bioprinted Triple-Layered Human Alveolar Lung Models

The triple-cell layered lung model was realized through high-precision patterning of multiple cell-laden biomaterials printed directly into culture dishes, enabled by the combination of multiple drop-on-demand 3D bioprinting printheads in the same process, alternating collagen layers with polyvinylpyrrolidone (PVP) bioink embedding human lung ...

ByRegenhu


Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

However, ENDS exposure, independent of nicotine, altered lung lipid homeostasis in alveolar macrophages and epithelial cells. ...

ByJohnson Controls, Inc.


Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles

Recent data highlight the concept of a “reprogrammed” lung epithelium as critical in the development of lung fibrosis. Extracellular vesicles (EVs) are potent mediators of cellular crosstalk, and recent evidence supports their role in lung pathologies, such as IPF. Here, we demonstrate that syndecan-1 is overexpressed by the ...

ByJohnson Controls, Inc.


Nanomechanics of lung epithelial cells

Nanomechanics of lung epithelial cells

The stress-strain relationship allows us to compute the complex shear modulus of the cell. Lung epithelial cells probed with AFM and magnetic tweezers exhibit a power-law dynamics with a weak exponent. This dynamics conforms to the rheology of soft glassy materials, suggesting that cytoskeleton internal disorder and matrix agitation could govern the mechanical ...

ByInderscience Publishers

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