lung injury Articles
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Image-based measurement of alveoli volume expansion in an animal model of a diseased lung
This research aims to improve ventilation protocols in critical care by using appropriate computer models that take into account the essential lung mechanics. This paper automatically tracks the boundary of individual or groups of alveoli, and converts this into a pressure volume curve for three different types of alveoli. Schiller et al. investigate the inflation and deflation of alveoli in a ...
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Exhaled air dispersion during noninvasive ventilation via helmets and a total facemask
Abstract Background: Noninvasive ventilation (NIV) via helmet or total facemask is an option for managing patients with respiratory infections in respiratory failure. However, the risk of nosocomial infection is unknown. Methods: We examined exhaled air dispersion during NIV using a human patient simulator reclined at 45° in a negative pressure room with 12 air changes/h by two ...
By Inspir Labs
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When in Rome—SOT Funding Enables Training in Isolating and Culturing Mesenchymal Stem Cells
I was fortunate to receive the SOT Supplemental Training for Education Program (STEP) award. With this award, I traveled to Sapienza Università di Roma in Italy, to the laboratory of Dr. Rita Businaro for what was intended to be a three-month training period focused on mesenchymal stem cells (MSCs), cells that modulate immune response and tissue repair. Dr. Businaro is an expert in MSCs ...
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Nebulised MSC-Derived EVs: A Potential Therapy for E. coli-Induced Pneumonia
Mesenchymal stem cells (MSCs) have shown great promise in cell therapy for various diseases, including lung injury. However, recent research has focused on the therapeutic potential of extracellular vesicles (EVs) derived from MSCs. These EVs contain bioactive molecules that can modulate immune responses and promote tissue repair. In the context of pneumonia caused by Escherichia coli (E. coli) ...
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Exhaled air dispersion distances during noninvasive ventilation via different Respironics face masks
Abstract Background: As part of our influenza pandemic preparedness, we studied the exhaled air dispersion distances and directions through two different face masks (Respironics; Murrysville, PA) attached to a human-patient simulator (HPS) during noninvasive positive-pressure ventilation (NPPV) in an isolation room with pressure of -5 Pa. Methods: The HPS was positioned at 45 degrees on ...
By Inspir Labs
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COVID-19 Clinical Report for Dead Infected Case
Clinical analysis of 25 novel coronavirus pneumonia deaths:asphyxia due to pulmonary mucus Pengpai news reporter Wu Yi Pengpai news ,February 29 On February 25, MedRxiv published a paper from Wuhan University People's Hospital, Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China. The ...
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Unveiling the Role of CD73: A Key Player in Immune Regulation and Beyon
What is CD73? CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked ...
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Understanding the Pulmonary Effects of Inhaled Arsenic Trioxide (ATO)
Arsenic trioxide (ATO) is an inorganic arsenical that poses significant environmental and public health risks due to its toxic nature. While it is widely used in various industrial and medicinal applications, the potential harm caused by intentional or accidental exposure cannot be overlooked. Despite its prevalence, the pulmonary pathology resulting from acute high-dose exposure to ATO has not ...
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Biorep Innovation Partner to COVID-19 Stem Cell Therapy Trial
After a lightning round of proposals and reviews, an international team of scientists led by Dr. Camillo Ricordi was granted immediate FDA authorization for a 24-patient clinical trial to test the safety and exploratory efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) to block the life-threatening lung inflammation that accompanies severe cases of COVID-19. The therapy uses ...
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