metabolic changes Articles
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Influence of dietary cholesterol and stress on the metabolism of linoleic acid: Δ6-desaturase activity vs. product/precursor ratios
Δ6-desaturase is a membrane bound enzyme located in a pivotal position within the Essential Fatty Acid metabolic pathway. Changes in the activity of Δ6-desaturase affect the cellular provision of long chain polyunsaturated fatty acids and therefore factors that influence this enzyme are considered relevant to disease processes. This study investigated the effects of social isolation stress and ...
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Estimation of nitrogen stable isotope turnover rate of Oncorhynchus nerka
Estimation of the isotopic turnover rate in the tissues of organisms allows us to estimate the temporal relationship between the isotope ratio of an organism and its prey, and to analyze seasonal variations of food webs and migratory patterns of animals. We analyzed the isotopic turnover rate in the tissue of lacustrine sockeye salmon, Oncorhynchus nerka, of three age classes in a laboratory food ...
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Protein PPARd Can Induce Rapid Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
In a new study, researchers from the Icahn School of Medicine at Mount Sinai have developed a reproducible and scalable method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs), and hPSC-CMs produced by human stem cell lines in the laboratory support myocardial contraction, which will improve methods for disease modeling, regenerative therapy, and drug ...
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Degradation of splicing factor SRSF3 contributes to progressive liver disease
Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), ...
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What Is Metabolomics?
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including the detection and analysis of metabolite types and quantities and ...
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Andrea Wolkenberg : Why Winback TECAR and Why Now?
As a physical therapist for over 40 years, I have developed a core set of values, chief among them is dedication to lifelong learning. And the more I learn the more I realize how much I don’t know it’s a humbling, frustrating, energizing, exciting and exhausting realization. But at the same time, the more I learn the more I realize how connected and integrated so many of the ...
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Continuous Metabolic Monitoring with the miniDOT® Logger
Case Study Description Warming Waters and Metabolic Rates As climate change continues to warm our world and its waters, scientists and researchers across the globe have spent years attempting to understand and predict the ramifications such warming will have on Earth’s ecosystems. Predictions can range from mild effects to the catastrophic, but one team of researchers are finding that a ...
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Novel Mechanism of Glycosylation Regulating Pancreatic Cancer Reveled
Pancreatic cancer is a highly malignant digestive system tumor, and the five-year survival rate of patients after diagnosis is only about 10%. Changes in metabolism are one of the important features of tumor cells. Tumor cells undergo metabolic reprogramming to generate the substances, energy, and redox forces required for their rapid proliferation. The proliferation of pancreatic ductal ...
By CD BioGlyco.
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Glucose metabolism: key to neurodegenerative diseases
Previously, it was thought that glial cells, which support neuronal activity, metabolize most of the glucose in the brain. However, by using induced pluripotent stem cells, the researchers found that neurons were able to take up glucose and process it into smaller metabolites. In mice, normal function of neurons depends on glycolysis. The findings could help develop new treatments for ...
By CD BioGlyco.
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Human Intestinal Ecosystem Analysis
The gut is a complex ecosystem that contains an extremely large community of microbes known as the gut microbiome. The gut microbiome is made up of bacteria, archaea, viruses, fungi, and other eukaryotic microorganisms, including yeasts, flagellates, ciliates, and protozoa. The gut microbiota of a healthy individual consists of six phyla (Firmicutes, Bacteroidetes, Proteobacteria, ...
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Introduction to Protein N-glycosylation
Glycosylation is one of the most important protein post-translational modifications in organisms, occurring in 50%-70% of proteins in cells. It is associated with many diseases as it can affect essential life activities, such as cell recognition, differentiation, adhesion, signal transduction, and immune response. Immune diseases, congenital sugar defects, and dozens of genetic diseases, as well ...
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Big data analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
The bioreactor’s environment and media contents affect the metabolism and productivity of a cell line. Traditional analytics like pH, temperature, dissolved gas levels, and titer reveals useful but incomplete information about the cells’ metabolism. Extracellular metabolites and nutrients in the cell media can be monitored to provide some information about the health of the cells. ...
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The Effect of Probiotics for the Gut Health
There are trillions of microbes inhabiting the human intestine. These microbes gradually reach a balance of types and numbers during the process of reproduction, and this balance is closely related to the body's normal metabolism. Once the structure of the intestinal flora becomes imbalanced, various metabolic diseases will follow. The probiotics multiply in large quantities in the intestine, ...
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Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis
Abstract Gut microbiota play an important role in immune responses and energy metabolism. In this study, we evaluated whether administration of Lactobacillus fermentum (L. fermentum) KBL375 isolated from healthy Korean feces improves the atopic dermatitis using the house dust mite (Dermatophagoides farinae)-induced atopic dermatitis (AD) mouse model. Administration of L. fermentum KBL375 ...
By KoBioLabs
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Epitranscriptomic Modifications and How to Detect Them
What is epitranscriptomic modification? RNA modifications, not limited to purine or pyrimidine bases, including N6-methyladenosine (m6A), 1-methyladenosine (m1A), 5-methylcytidine (m5C), 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (f5C), 5-carboxycytidine (ca5C), inosine (I), pseudouridine (Ψ), and 2′-O-methylation (Nm). RNA modifications can structurally alter the pairing of ...
By CD Genomics
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Evolution, Conservation, Change, Robustness, Complexity and Degeneracy
For species to be successful and adapt to an ever changing environment, they must strike a delicate balance between allowing for some DNA alterations, while at the same time preserving the key developmental processes encoded in their unique genomes. This poses a problem, as even small changes in any given gene might lead to deleterious effects that decrease the ability of any individual to ...
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Remote Oncology Care: Review of Current Technology and Future Directions
Abstract Cancer patients frequently develop tumor and treatment-related complications, leading to diminished quality of life, shortened survival, and overutilization of emergency department and hospital services. Outpatient oncology treatment has potential to leave cancer patients unmonitored for long periods while at risk of clinical deterioration which has been exaggerated during the COVID19 ...
By Oncodisc
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Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
ABSTRACT Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using Lactobacillus paracaseiKBL382 isolated from the feces of healthy Koreans. Mice with Dermatophagoides farinaeextract (DFE)-induced AD were fed 1 × 109 CFU ...
By KoBioLabs
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