Metabolic Disorder Articles & Analysis
31 articles found
TCA Cycle Analysis in Research Recent advancements in metabolomics have shed light on the importance of TCA Cycle analysis in various fields of research, including cancer biology, cardiovascular health, and metabolic disorders. By examining the levels of TCA Cycle intermediates and associated metabolites, scientists can gain insights into cellular ...
Disease Modeling: Custom knockout cell lines can mimic specific diseases by disabling genes associated with particular disorders. This modeling can be invaluable for studying the pathophysiology of diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. ...
One essential approach to studying cellular metabolism is Metabolic Flux Analysis (MFA), a powerful tool that reveals the intracellular activities and metabolic dynamics of living systems. ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. ...
An imbalance of NAD⁺ and NADH levels can lead to metabolic disorders and oxidative stress. Biosynthesis and Signaling: Beyond redox reactions, NAD⁺ also acts as a substrate for enzymes like sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38, which regulate DNA repair, aging, and cell signaling. ...
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant public health concern, associated with obesity, insulin resistance, and a spectrum of metabolic disorders. Understanding this condition is crucial for effective intervention and treatment. ...
They are implicated in a wide range of conditions, from cardiovascular and metabolic disorders to neurological diseases and cancers. By facilitating the early stages of the drug development pipeline, GPCR Screening Services help streamline the identification of lead compounds, optimizing the chances of successful therapeutic outcomes. ...
This mimetic action allows researchers to enhance or restore the expression of target genes that are otherwise downregulated in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Mechanism of Action Upon introduction into cells, miRNA mimics enter the RNA-induced silencing complex (RISC), where they bind to complementary mRNA targets. ...
Beyond their roles in blood flow regulation and inflammation, SMECs contribute to metabolic functions within skeletal muscle. They participate in the uptake and delivery of glucose and fatty acids, influencing the metabolic state of the muscle. This function is particularly important in the context of metabolic disorders such as ...
They have shown great potential in treating various diseases, such as cancer, autoimmune diseases, infectious diseases, and metabolic disorders. However, to ensure the safety and efficacy of these drugs, strict quality control and characterization are necessary. ...
Peptidomimetics can also stabilize secondary structures, such as alpha-helices or beta-sheets, which are critical for the function of proteins and increase the stability and potency of therapeutic peptides.Peptidomimetics ResearchPeptidomimetics have been successfully developed for a wide range of therapeutic applications, including cancer, infectious diseases, and metabolism ...
Spectroscopic MethodsInfrared spectroscopy and Raman spectroscopy can also be used to analyze the glycation structure and changes of collagen.These methods can be used separately or in combination to obtain a comprehensive understanding of the structure and function of glycated collagen.The detection of glycated collagen is also one of the methods used to assess diabetes and glucose ...
Consequently, prolidase deficiency has been linked to various medical conditions, including skin disorders, chronic wounds, and certain genetic disorders. In the pharmaceutical and nutraceutical sectors, Native Porcine Prolidase is used as a dietary supplement to support skin health, wound healing, and collagen synthesis. ...
Many abnormal physiological states are associated with disorders of lipid metabolism. Studying the changes of lipids in different states of the organism at the systemic level can help analyze the mechanisms of lipid metabolic networks. ...
Sleep apnea is a severe sleeping disorder in which a person experiences interruptive breathing or loud snoring. Long-term untreated or undiagnosed sleep apnea can cause several health problems, such as daytime sleepiness, cognitive impairment, fatigue, and metabolic disorders. The development of groundbreaking sleep apnea devices, including ...
This process occurs in plants through photosynthesis and in animals through various metabolic pathways. The synthesis of carbohydrates involves a series of enzymatic reactions that convert simple molecules into more complex structures. ...
These oral antidiabetic medications mainly work by increasing insulin sensitivity, slowing down the metabolism of carbohydrates in the small intestine, repairing and improving the function of pancreatic β-cells, and promoting insulin secretion to achieve blood glucose reduction. ...
Rare diseases, also known as orphan diseases, are a diverse group of disorders that affect a small percentage of the population. Due to their low prevalence and limited understanding, treating and finding cures for these conditions present significant challenges. ...
Diabetes Models Broadly, diabetes models offer an effective tool to study the multidimensional nature of this metabolic disorder. These models include in vivo animal models, in vitro cell culture models, in silico (computer-based) models, and genetically modified organism models. ...
Pharmaceutical Industry: In pharmaceuticals, α-Galactosidase plays a vital role in the development of medications targeting digestive health and metabolic disorders. The goal is to increase the efficacy of these medications for better patient outcomes. ...