metabolic function Articles
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Metabolomics in Gut Microbiota Research
With rapid development in sequencing technology, researchers can better assess the effect of the gut microbiome on human health. Human beings have a symbiotic relationship with the microbiota since birth. The environment, proximity to other humans and animals, diet, genetics, and time changes can all affect the microbial composition of our skin, mouth, and intestines. Compared with other ...
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Bioinformatics Analysis of 16S rRNA Amplicon Sequencing
This article provides a brief introduction to good practices for the bioinformatics analysis of 16S rRNA sequencing by NGS (next-generation sequencing). The bioinformatics pipeline involves two main stages: the preprocessing of data (quality control) and quantification (including taxonomic profiling and predictive metagenomics profiling). Preprocessing to eliminate uninformative data Removal of ...
By CD Genomics
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High-throughput identification and validation of in situ-expressed genes of lactococcus lactis
Understanding the functional response of bacteria to their natural environment is one of the current challenges in microbiology. Over the past decades several techniques have been developed to study gene expression in complex natural habitats. Most of these methods, however, are laborious, and validation of results under in situ conditions is cumbersome. Here we report the improvement of the ...
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Recent developments in therapeutic applications of atomic and nuclear radiations
In recent years, the major 'challenge' of radiation treatment is to deliver large enough doses to the most resistant cancer cells to provide a high probability of local control while minimising the dose to normal tissues and hence reducing complications. With recent developments in 'imaging' the metabolic or functional status of cancers, the position of tumours relative to surrounding normal ...
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Fenitrothion, an organophosphorus insecticide, impairs locomotory function and alters body temperatures in Sminthopsis macroura (Gould 1845) without reducing metabolic rates during running endurance and thermogenic performance tests
Endemic Australian mammal species are exposed to pesticides used for locust control as they occupy the same habitat as the target insect. We examined the impact of an ultra‐low volume (ULV) formulation of the organophosphorus insecticide, fenitrothion (O,O‐dimethyl‐O‐(3‐methyl‐4‐nitrophenol)‐phosphorothioate), on a suite of physiological measures that affect the ability of animals to survive ...
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Lipidomics in Microbial Research
Lipids are a class of metabolites with diverse chemical structures. More than just components of cell membranes and energy storage substances, lipids can perform a variety of important biological functions in life activities. The structural diversity of lipids endows them with a variety of important biological functions: (1) they constitute an important component of the cell membrane. Many ...
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Focal Molography, A Guide Inside Cellular Pathways
Focal Molography, a Guide Inside Cellular Pathways There are billions of cells in our bodies, each with their own characteristics and functions. To function together, cells need to communicate; during the evolution of multi-cellular organisms, cells have developed communication systems of exceptional complexity. These systems govern every level of communication, and together they dictate cell ...
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Algatech Triples FucoVital Production Capacity
Fucovital is the first tiver health support extract derived from microalgae Kibbutz Ketura, Israel—Algatechnologies, Ltd. ("Algatech") announces it has tripled its production capacity for FucoVital .The action follows increased demand from the dietary supplements market. FucoVital was launched in the U.S. in 2018. Algatech's Fucovital proprietary fucoxanthin oleoresin is the world's ...
By Algatech
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Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish
Pharmaceuticals and personal care products (PPCPs) are emerging contaminants that have been found ubiquitously in wastewater and surface waters around the world. A major source of these compounds is incomplete metabolism in humans and subsequent excretion in human waste, resulting in discharge into surface waters by wastewater treatment plant (WWTP) effluent. One pharmaceutical found in ...
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Regulation of cancer by therapeutic vaccination and dietary bio-modulation involving organ-specific mitochondria
Cancer therapy should aim to prevent recurrent disease. Surgery and toxic treatments remove only symptoms associated with cancer without trying to intervene in the aetiology, therefore the disease may recur. The autologous cancer vaccine supplemented with bio-modulation might fulfil requirements for effective tumour therapy. The autologous tumour vaccine is formed in the same way as our bodily ...
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Treatment for shoulder pain - Case Study
Treatment for shoulder pain Gabi Zeilig, MD, Dept of Neurological Rehabilitation The Chaim Sheba Medical Center, Tel Hashomer, Israel. Purpose of the study: to test the efficacy of the TerraQuant medical device on shoulder pain resulting from inflammation (OA, Tendonitis, Bursitis). Background: TerraQuant is a unique device which combines low level pulse laser therapy (LLLT), pulsating ...
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Introduction to Lipogenesis, Lipid Anabolism and Catabolism
Sources of Fat Fat, also known as triglyceride, is made by condensing one molecule of glycerol and three fatty acids. The source of fatty acids in the body: one is the body's own synthesis, and the other is the food supply. Some unsaturated fatty acids cannot be synthesized by the body and depend on food supply, called essential fatty acids. There are mainly two kinds, one is the ω-3 series ...
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Human Intestinal Ecosystem Analysis
The gut is a complex ecosystem that contains an extremely large community of microbes known as the gut microbiome. The gut microbiome is made up of bacteria, archaea, viruses, fungi, and other eukaryotic microorganisms, including yeasts, flagellates, ciliates, and protozoa. The gut microbiota of a healthy individual consists of six phyla (Firmicutes, Bacteroidetes, Proteobacteria, ...
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Amplicon Sequencing Technology Unveils the Enigmas of Microbial Populations
Amplicon sequencing is a cutting-edge technique that involves sequencing PCR products or captured fragments of specific lengths, enabling the analysis of sequence variations. Among the diverse applications of this technology, the 16S rRNA gene has emerged as a fundamental tool for sequence-based bacterial analysis, boasting decades of significance. The process of 16S/18S/ITS amplicon sequencing ...
By CD Genomics
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Fatty Acids in Cancer
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. And the activation of ab initio synthesis is negatively ...
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What are Cannabinoids?
The term “cannabinoids” originally described bioactive constituents of the plant Cannabis sativa, a plant that can grow wild in mild, tropical climates around the world. For centuries, the cannabis ingredients were used traditionally for their medicinal purpose but also for their recreational properties; however, only since the 1940s have cannabinoids been purified from cannabis ...
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A New System for the Regulation of Glucose and Lipid Metabolism Found
Diabetes affects more than 400 million people worldwide and is a huge public health burden. Obesity is a major risk factor for diabetes and leads to insulin resistance that often precedes diabetes. Currently, genome-wide association studies (GWAS) have identified more than 80 diabetes susceptibility loci, and an increasing number of mutations and variants have been identified in monogenic forms ...
By CD BioGlyco.
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“Harmless” Bacteria Cause Autoimmune Disease
Organs influenced by immune dynamics in the gut.(1) A Gut Check for Tumor Overgrowth Enzymes Work Better in a Cage Are IPS Cells Safe for Therapeutic Use? Factors contributing to autoimmune disease development. (2) The human body is the site of a flagrant yet silent invasion. We host as many foreign organisms in and on us as we have cells that make up our own body. A particular ...
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Bile Acid: A Comprehensive Exploration of Function and Metabolism
In the realm of biological sciences, bile acids stand as pivotal molecules, playing a multifaceted role in various physiological processes within organisms. Bile acids are specialized molecules synthesized from cholesterol within the liver. These amphipathic compounds possess a hydrophilic region (carboxylic acid moiety) and a hydrophobic region (steroid backbone). Their distinctive structure ...
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Human Microbiome Research Promotes Progress of Precision Medicine
A large part of bacterial, archaeal, viral, and fungal microbial taxa consists of the human microbiome. While many of these microorganisms are commensal, some are harmful to humans and many are symbiotic. Our livelihoods are strongly intertwined with the microbes we allocate our bodies with, regardless of whether their appearance is advantageous, insignificant, or harmful. Over the past few ...
By CD Genomics
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