Metabolic Pathway Articles & Analysis: This-Year
11 articles found
Synthetic biology is driving the design of entire metabolic pathways assembled via modular enzymes, allowing for on-demand biosynthesis of complex molecules. ...
Despite these challenges, this field continues to expand, offering increasingly personalized and effective treatments for various malignancies. Cardiovascular and metabolic APIs address some of the most prevalent health challenges globally. ...
Moreover, S9 assays help in predicting drug-drug interactions. Many drugs are metabolized by the same pathways; thus, understanding the metabolic profile can provide insights into potential interactions that might lead to adverse effects. ...
Role in Drug Metabolism The role of cytochrome P450 in drug metabolism is two-fold: it can either detoxify drugs or convert them into active metabolites. The metabolic pathways involving CYP enzymes are generally categorized into two phases: Phase I Reactions: These involve the introduction or modification of functional groups on ...
Biosynthesis: Intermediates of the TCA Cycle serve as precursors for the biosynthesis of amino acids, heme, and other essential biomolecules. Metabolic Flexibility: The cycle can integrate inputs from various metabolic pathways, allowing cells to adapt to changing nutritional states. ...
Various factors contribute to this phenomenon, including genetic mutations, alterations in drug targets, enhanced drug efflux, and changes in metabolic pathways. In cancer, the heterogeneity of tumors often results in a subset of cells that can survive initial treatments, leading to relapse and metastasis. ...
This method allows researchers to map the flow of material (carbon, nitrogen, or other molecules) through different metabolic pathways. By determining the flux of these compounds, scientists can uncover how organisms regulate energy production, biosynthesis, and other critical cellular processes under various conditions. MFA works by combining experimental data ...
NAD and NADH are not merely passive participants in metabolism—they are regulatory molecules that influence key metabolic pathways, including glycolysis, oxidative phosphorylation, and biosynthetic reactions. ...
Conversely, exosome metabolomics provides valuable information about cellular metabolic reprogramming, particularly in diseases such as cancer, neurodegeneration, and metabolic disorders. ...
This capability is instrumental in understanding the genetic basis of traits, discovering new genes, and exploring metabolic pathways. In addition to fundamental research, fosmid libraries are employed in medical and pharmaceutical applications. ...
ADME stands for Absorption, Distribution, Metabolism, and Excretion, which are critical processes that determine the fate of a drug within the body. ...