metabolism pathway Articles
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PCE and TCE Aerobic Cometabolic Pathways
Aerobic cometabolism of PCE and TCE using the proprietary blend of cultures in CL-Out has been successful at numerous field applications without a full understanding of the metabolic pathways. Recent microcosm studies have shown that trichloro and dichloroacetic acids are transient intermediates in the degradation of PCE and TCE under aerobic conditions. These intermediates suggest the ...
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Synthetic Biology for the Production of Biobased Molecules
How does synthetic biology technology lead to the production of novel biobased chemicals? The ShikiFactory100 project aims to produce a collection of over 100 high-value compounds from the shikimate pathway, a metabolic pathway widely used by organisms in nature (e.g. bacteria, fungi and plants) to synthesise the aromatic amino acids (AAAs) phenylalanine (Phe), tryptophan (Trp) and tyrosine ...
By NNFCC Ltd.
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Influence of dietary cholesterol and stress on the metabolism of linoleic acid: Δ6-desaturase activity vs. product/precursor ratios
Δ6-desaturase is a membrane bound enzyme located in a pivotal position within the Essential Fatty Acid metabolic pathway. Changes in the activity of Δ6-desaturase affect the cellular provision of long chain polyunsaturated fatty acids and therefore factors that influence this enzyme are considered relevant to disease processes. This study investigated the effects of social isolation stress and ...
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Uptake and metabolism of individual PBDE congeners by embryonic zebrafish
Embryonic zebrafish were used to compare the uptake and metabolism for six polybrominated diphenyl ether (PBDE) congeners (BDE 28, 47, 99, 100, 153, and 183) and identified metabolites from static exposures at 24 and 120 hours post fertilization. An inverse relationship was observed between PBDE uptake and their octanol‐water partitioning coefficient (uptake of BDE 28 and 47 > 99 and 100 > 153 ...
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Introduction to Glucosidase
Glucosidase is a large class of enzymes in glycoside hydrolase (EC 3.2.1). It is named because it can hydrolyze the glucoside bond and release a molecule of glucose. Glucosidase has a wide range of sources, and it exists in almost all organisms with cellular structure that use carbohydrates as energy sources. According to the classification of the Carbohydrate-Active enZYmes Database (CAZy) ...
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Into the future with breath analysis
Human breath contains up to a thousand volatile organic compounds that, when analysed, can tell a story about a body’s state of health. These chemical compounds reflect the end processes of metabolic pathways. Patterns of compound peaks form ‘signatures’ when breath is analysed into its components and it is these signatures that allow for disease conditions to be identified. ...
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Platform technologies to support brain-computer interfaces
There is a lack of adequate and cost-effective treatment options for many neurodegenerative diseases. The number of affected patients is in the millions, and this number will only increase as the population ages. The developing areas of neuromimetics and stimulative implants provide hope for treatment, as evidenced by the currently available, but limited, implants. New technologies are emerging ...
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Carbohydrate Synthesis: Understanding the Building Blocks of Life
Carbohydrates are one of the essential macromolecules that play a crucial role in the functioning of living organisms. They serve as a primary source of energy and are involved in various biological processes. The synthesis of carbohydrates is a complex and fascinating process that occurs in living organisms, allowing them to produce and utilize these vital molecules. In this blog post, we will ...
By CD BioGlyco.
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TBECH‐mediated steroid hormone receptor activation and gene regulation in chicken LMH cells
The incorporation of brominated flame retardants into industrial and household appliances has increased their occurrence in the environment resulting in deleterious effects on wildlife. With the increasing restraints on available compounds there has been a shift to using BFRs that has seen the production of alternative BFRs such as 1,2‐dibromo‐4‐(1,2 dibromoethyl) cyclohexane (TBECH). TBECH ...
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Strain Improvement in Yeast
Yeast is a single-celled and versatile microorganism that is widely used in various industries, such as brewing, food, and biotechnology. However, not all yeast strains possess the desired characteristics required for optimal production. Therefore, methods of yeast strain improvement have been developed to enhance the desirable traits of yeast strains and to benefit industries involving yeast. ...
By BOC Sciences
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Big data analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process
The bioreactor’s environment and media contents affect the metabolism and productivity of a cell line. Traditional analytics like pH, temperature, dissolved gas levels, and titer reveals useful but incomplete information about the cells’ metabolism. Extracellular metabolites and nutrients in the cell media can be monitored to provide some information about the health of the cells. ...
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Organic Acids Analysis
The organism undergoes thousands of biochemical reactions every moment to maintain our growth, development and energy metabolism. Under normal circumstances, these biochemical reactions proceed smoothly step by step through various cycles or certain steps. The process by which the body changes carbohydrates, amino acids, and fats from nutrients to absorbable substances and wastes is called the ...
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Effects of a natural toxin on life‐history and gene expression of Eisenia andrei
Earthworms perform key functions for a healthy soil ecosystem, such as bioturbation. The soil ecosystem can be challenged by natural toxins such as isothiocyanates (ITC), produced by many commercial crops. Therefore, the effects of 2‐phenylethyl ITC were investigated on the earthworm Eisenia andrei using an ecotoxicogenomics approach. Exposure to 2‐Phenylethyl ITC reduced both survival and ...
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Magnesium ions improving the growth and organics reduction of
Rhodospirillum rubrum cultivated in sewage through regulating energy metabolism pathwaysRhodospirillum rubrum has the potential for biomass resource recycling combined with sewage purification. However, low biomass production and yield restricts the potential for sewage purification. This research investigated the improvement of biomass production, yield and organics reduction by Mg2+ in R. rubrum wastewater treatment. Results showed that with optimal dosage (120 mg/L), ...
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What Is Metabolomics?
Metabolism is the assembly of biochemical reactions in living organisms, the material basis for life maintenance of living organisms, and an important basis for the study of life activities. Metabolomics studies the endogenous metabolic activities of life under the influence of the internal and external environments, including the detection and analysis of metabolite types and quantities and ...
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Lipidomics in Microbial Research
Lipids are a class of metabolites with diverse chemical structures. More than just components of cell membranes and energy storage substances, lipids can perform a variety of important biological functions in life activities. The structural diversity of lipids endows them with a variety of important biological functions: (1) they constitute an important component of the cell membrane. Many ...
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Creative Proteomics Metabolomics Launches Coenzyme A (CoA) Analysis Service for Precision Metabolomics Research
Metabolomics, a division of Creative Proteomics, is dedicated to providing cutting-edge LC-MS-based metabolomics services for biomedical research institutions as well as biotechnological and pharmaceutical companies. Creative Proteomics Metabolomics has announced the launch of its advanced coenzyme A (CoA) analysis service for precision metabolomics research. This new service leverages the ...
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Recursion Pharmaceuticals Puts Strength on Full Display
The drug developer's latest capital raise, a $150 million private placement, comes during a difficult market environment. The strongest companies can raise money in any environment. Recursion Pharmaceuticals (RXRX) - Get Free Report recently raised $150 million in gross proceeds from a private placement of common stock, including half from a single fund that has never before invested in the ...
By Recursion
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Enzymatic Mechanism by Which Dolphin Gut Microbes Degrade Plant Polysaccharides Unveiled
Symbiotic microbial groups within the digestive tract of herbivores are the main source of depolymerized lignocellulases. The dolphin is the largest extant rodent, usually living in the Pantanal wetland and Amazon basin, and is also known as the "king of grass" due to its diet based on grasses and aquatic plants. They can efficiently depolymerize and utilize lignocellulosic biomass through ...
By CD BioGlyco.
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Exercise in the morning or in the evening has a completely distinct effect!
Life is all about working out. Moderate exercise not only strengthens the body, but also improves the metabolic state and slows the progression of diseases. However, different times of exercise may have different impacts, and it is an intriguing scientific question how to determine the best time to exercise. Although the influence of exercise on energy metabolism is well recognized, there is ...
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