microbiome Articles
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Testing of a drug panel for effects on the gut microbiome using RapidAIM
MedBiome’s founders reported in Microbiome the development of the RapidAIM platform to screen compounds against individual microbiomes in vitro. They tested 43 compounds (including 4 antibiotics) against 5 individual microbiomes using the RapidAIM technology. The RapidAIM workflow provides insights into microbiome absolute abundance and functional responses to ...
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CP101, an Investigational Oral Microbiome Therapeutic for the Prevention of Recurrent C. difficile Infection
Background: Disruption of the microbiome is key to the pathogenesis of recurrent Clostridioides difficile infection (CDI). Place bo-control led trials assessing microbiome therapeutics have demonstrated efficacy in recurrent CDI; hov/ever, long-term safety and efficacy data from rigorously conducted studies of microbiome therapies, including cumulative efficacy in those who received a second dose ...
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The gut microbiome impacts the brain
What we eat and how it is processed by the gut is proving to be more important that ever. Research is showing that the gut microbiome has a significant impact on the brain. Brain health in impacted in significant ways both negatively and positively based upon the gut microbiome. Structural bacterial components can stimulate the brain to improve the immune system. When the gut microbiome is ...
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ART and the Vaginal Microbiome
The link between the vaginal microbiome and pregnancy outcomes is so strong that someone’s vaginal microbiome can actually be used to predict IVF success What is the vaginal microbiome? Your vaginal microbiome is the community of microbes living in your vagina. A healthy vaginal microbiome typically has low diversity and is dominated by a type of good bacteria called Lactobacillus that ...
By Juno Bio
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Beyond Fecal Microbiota Transplantation: Developing Drugs from the Microbiome
Abstract The transfer of live gut microbes may transform patient care across a range of autoimmune, metabolic, hepatic, and infectious diseases. One early approach, fecal microbiota transplantation, has shown promise in Clostridiodes difficile infection and the potential for improving clinical and public health outcomes for other antibiotic-resistant bacteria. These clinical successes have ...
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Biosortia-at scale mining of nature’s metabolite bounty
Biosortia is building the world’s largest library of microbiome-derived compounds for therapeutic and other applications, by leveraging the company’s microbial harvesting platform to sample and mine aquatic microbiomes at unprecedented scales with sustainable and environmentally friendly approaches. Biosortia is seeking partners interested in accessing compounds and chemistries to ...
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What Is Microbiome and How to Study It
The term microbiome comes from the Greek word micro which means small and bios meaning life. It is defined as "a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physiochemical properties". Many researchers in the past defined microbiome based on different contexts such as ecological and genetic aspects. However, scientists noted some gaps in these ...
By CD Genomics
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Food Allergies and the Gut Microbiome
Food allergies are on the rise to level not seen in previous generations. Many hypotheses have been put forward as to the cause of increases in these food allergies. New studies involving mice have shown that certain probiotics being introduced into the gut Microbiome of these mice have been able to stop certain food allergies, such as an allergy to peanuts. By introducing the probiotic the ...
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Development of a highly specific and productive process for
n- caproic acid production: applying lessons from methanogenic microbiomesHigh productivity and specificity in anaerobic digesters arise because complex microbiomes organize into a metabolic cascade to maximize energy recovery and to utilize the advantage that the gaseous end product methane freely bubbles out of the system. These lessons were applied to ascertain whether a reactor microbiome could be shaped to produce a different end product. The liquid product ...
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Introduction to Microbiomics
Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...
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Introduction to Microbiomics
Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...
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Full-length 16s Sequencing Unlocks the Microbial World
Since the first discovery of 16s rRNA sequences in environmental samples in 1990 and their value in microbial community research, we have entered the era of microbial community research in full swing. Today, community research has entered the high throughput sequencing era, and the mainstream of current research is at the intersection of next-generation amplicon sequencing and long-read amplicon ...
By CD Genomics
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Human Microbiome Research Promotes Progress of Precision Medicine
A large part of bacterial, archaeal, viral, and fungal microbial taxa consists of the human microbiome. While many of these microorganisms are commensal, some are harmful to humans and many are symbiotic. Our livelihoods are strongly intertwined with the microbes we allocate our bodies with, regardless of whether their appearance is advantageous, insignificant, or harmful. Over the past few ...
By CD Genomics
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CD Genomics Perspective: Sequencing Methods and Bioinformatics for Microbial Genomics
Metagenomic sequencing of microbial specimens is progressively employed to define novel mobile genetic elements (MGEs), which are crucial to our knowledge of how genes (and their associated components) move within a community through horizontal gene transfer (HGT) within a community, even after having to surmount significant obstacles. To recognize and explore novel as well as recognized MGEs, ...
By CD Genomics
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How Probiotics Help Restore Balance to the Gut Microbiome
Probiotics are living microorganisms that offer numerous health benefits when consumed in adequate amounts. These beneficial bacteria can be found in various fermented foods such as yogurt, kefir, sauerkraut, and kimchi, as well as in dietary supplements. The term "probiotic" is derived from the Greek words "pro" and "biotic," which mean "for life." Probiotics have gained popularity in recent ...
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CD Genomics Perspective: High-Throughput Sequencing Approach to Explore the Human Microbiome
The Use of Microbiome Sequencing in Cancer Research A growing body of evidence now suggests that human microbial dysbiosis has a crucial role in cancer development and progression. Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of ...
By CD Genomics
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The Relationship Between the Gut Microbiome and Drugs Is Greater Than We Thought
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from ...
By CD Genomics
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Symberix Featured in Nature
Durham, NC (February 3, 2020) - An article in Nature highlights Symberix's efforts to understand the complex relationship between drugs and the microbiome. The paper discusses recent contributions to the emerging field of “pharmacomicrobiomics” -- the study of how microbes impact drug disposition, efficacy, and toxicity. Symberix is developing bacteria-targeted small molecules that ...
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Bioinformatics Analysis of 16S rRNA Amplicon Sequencing
This article provides a brief introduction to good practices for the bioinformatics analysis of 16S rRNA sequencing by NGS (next-generation sequencing). The bioinformatics pipeline involves two main stages: the preprocessing of data (quality control) and quantification (including taxonomic profiling and predictive metagenomics profiling). Preprocessing to eliminate uninformative data Removal of ...
By CD Genomics
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Vaginal Bacteria: How Much is Too Much?
What is microbial load? Microbial load helps to provide a more complete picture of your vaginal microbiome. Microbial load results are split into two parts: Bacterial load: an indication of the total amount of bacteria present in your vagina. Fungal load: an indication of the total amount of fungi present in your vagina. The microbial load results can help you to understand if your total ...
By Juno Bio
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