microbiome diversity Articles
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CP101, an Investigational Oral Microbiome Therapeutic for the Prevention of Recurrent C. difficile Infection
Background: Disruption of the microbiome is key to the pathogenesis of recurrent Clostridioides difficile infection (CDI). Place bo-control led trials assessing microbiome therapeutics have demonstrated efficacy in recurrent CDI; hov/ever, long-term safety and efficacy data from rigorously conducted studies of microbiome therapies, including cumulative efficacy in those who received a second dose ...
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Bioinformatics Analysis of 16S rRNA Amplicon Sequencing
This article provides a brief introduction to good practices for the bioinformatics analysis of 16S rRNA sequencing by NGS (next-generation sequencing). The bioinformatics pipeline involves two main stages: the preprocessing of data (quality control) and quantification (including taxonomic profiling and predictive metagenomics profiling). Preprocessing to eliminate uninformative data Removal of ...
By CD Genomics
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ART and the Vaginal Microbiome
The link between the vaginal microbiome and pregnancy outcomes is so strong that someone’s vaginal microbiome can actually be used to predict IVF success What is the vaginal microbiome? Your vaginal microbiome is the community of microbes living in your vagina. A healthy vaginal microbiome typically has low diversity and is dominated by a type of good bacteria called Lactobacillus that ...
By Juno Bio
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A "miracle" fruit that can enhance the immune response to tumors
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy remains a major obstacle limiting its clinical application. The development of drug resistance is associated with multiple factors, including the level of PD-L1 expression in tumor cells, the tumor microenvironment, ...
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CD Genomics Perspective: Sequencing Methods and Bioinformatics for Microbial Genomics
Metagenomic sequencing of microbial specimens is progressively employed to define novel mobile genetic elements (MGEs), which are crucial to our knowledge of how genes (and their associated components) move within a community through horizontal gene transfer (HGT) within a community, even after having to surmount significant obstacles. To recognize and explore novel as well as recognized MGEs, ...
By CD Genomics
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Preterm Birth and the Vaginal Microbiome
The vaginal microbiome has a profound impact on pregnancy health - here we dig into the science with an expert You might already be familiar with how the microbes that live in your vagina affect your health, especially when it comes to conditions like yeast infections or bacterial vaginosis (BV). But it’s not just about you - your vaginal microbiome (VMB) can also impact the outcome of ...
By Juno Bio
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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...
By KoBioLabs
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The Relationship Between the Gut Microbiome and Drugs Is Greater Than We Thought
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from ...
By CD Genomics
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Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans
Abstract Lactobacillusspecies are the predominant vaginal microbiota found in healthy women of reproductive age and help to prevent pathogen infection by producing lactic acid, H2O2 and anti-microbial compounds. Identification of novel vaginalLactobacillus isolates that exhibit efficient colonisation and secrete anti-Candida factors is a promising strategy to prevent vulvovaginal candidiasis. ...
By KoBioLabs
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