microbiome research Articles
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Introduction to Microbiomics
Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...
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Introduction to Microbiomics
Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...
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Amplicon Sequencing for Microbiome Research: Introduction, Advantages, and Applications
The identification of microbial groups is an important step in understanding the interrelationship of microorganisms in a community. It is done to determine all present microbial taxa and their relative abundance, and as well their phylogenetic relationships. One of the methods used to establish phylogenetic relationships is by sequencing common genes. One of the easiest genes to be sequenced are ...
By CD Genomics
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Human Microbiome Research Promotes Progress of Precision Medicine
A large part of bacterial, archaeal, viral, and fungal microbial taxa consists of the human microbiome. While many of these microorganisms are commensal, some are harmful to humans and many are symbiotic. Our livelihoods are strongly intertwined with the microbes we allocate our bodies with, regardless of whether their appearance is advantageous, insignificant, or harmful. Over the past few ...
By CD Genomics
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CD Genomics Perspective: High-Throughput Sequencing Approach to Explore the Human Microbiome
The Use of Microbiome Sequencing in Cancer Research A growing body of evidence now suggests that human microbial dysbiosis has a crucial role in cancer development and progression. Unlike earlier studies relying on culturing bacteria from the tissue of cancer, high-throughput sequencing methods have enabled genotyping the microbial ecosystem within cancer tissue from hundreds to thousands of ...
By CD Genomics
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New Findings from Universal DX: Through a Simple Blood Test, Our Body`s Gut Bacteria Can Help Detect Early-stage Colorectal Cancer
Company Presents Data at ESMO Congress Showing Link Between Microbiome Bacteria and Early Colorectal Cancer Detection (September 12, 2022) CAMBRIDGE, MA. - Universal Diagnostics (Universal DX), a bioinformatics and multi-omics company on a mission to transform cancer into a curable disease, today announced the results of a proof of principle study demonstrating that the analysis of microbiome ...
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Developing a Robust in Vitro Intestinal Model for Preclinical Candidate Screening of GI Toxicity
Gastrointestinal (GI) issues are common side effects of many drugs. Anticipating such side effects before clinical trials is limited by a lack of effective models for evaluating preclinical candidates for their potential to cause diarrhea, nausea, and other gut-related side effects. With its RepliGut® in vitro human intestinal model, Altis Biosystems is developing a system that could help ...
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Accurately Recapitulating Environmental Niches in Vitro Models of the Intestine
Advanced microphysiological systems can replicate aspects of intestinal complexity, such as epithelium self-renewal by stem cells in in vitro crypts or the interactions of microbes and intestinal epithelium mediated by a mucus layer. Availability of such models is key to progress in compound screening, disease modeling, and microbiome research. Defining a Niche A niche is a multidimensional ...
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Plant-based cures for Vector-borne disease
Herb- and plant-based medicines have been used for as long as 60,000 years, with the first written record dating to 7,000 years ago. While these medicines have survived scientific evaluation with varying success, one in four medications currently used has a plant-based origin. One of the most successful medications treats a vector-borne disease. With all this history, why aren’t we ...
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How does your Vaginal Microbiome Affect your Cancer Risk?
When you hear about the vaginal microbiome (VMB), your first thought may be the role it plays in stuff like yeast infections or bacterial vaginosis (BV). But with improved research, we’re uncovering more of the VMB’s long-term effects, like its role in a healthy pregnancy and delivery. The complex community of organisms living in your vagina even plays a part in your risk of ...
By Juno Bio
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Symberix Featured in PNAS
Durham, NC (April 28, 2020) - A review article published in PNAS highlights Symberix's efforts to understand the role of the human microbiota in drug efficacy and toxicity. Symberix co-founder Matt Redinbo is featured in the article alongside other leaders from the emerging field of “pharmacomicrobiomics” -- the study of mechanisms behind the microbial impact on drug metabolism. ...
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Preterm Birth and the Vaginal Microbiome
The vaginal microbiome has a profound impact on pregnancy health - here we dig into the science with an expert You might already be familiar with how the microbes that live in your vagina affect your health, especially when it comes to conditions like yeast infections or bacterial vaginosis (BV). But it’s not just about you - your vaginal microbiome (VMB) can also impact the outcome of ...
By Juno Bio
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Symberix Featured in Nature
Durham, NC (February 3, 2020) - An article in Nature highlights Symberix's efforts to understand the complex relationship between drugs and the microbiome. The paper discusses recent contributions to the emerging field of “pharmacomicrobiomics” -- the study of how microbes impact drug disposition, efficacy, and toxicity. Symberix is developing bacteria-targeted small molecules that ...
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A "miracle" fruit that can enhance the immune response to tumors
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy remains a major obstacle limiting its clinical application. The development of drug resistance is associated with multiple factors, including the level of PD-L1 expression in tumor cells, the tumor microenvironment, ...
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What Is Microbiome and How to Study It
The term microbiome comes from the Greek word micro which means small and bios meaning life. It is defined as "a characteristic microbial community occupying a reasonable well-defined habitat which has distinct physiochemical properties". Many researchers in the past defined microbiome based on different contexts such as ecological and genetic aspects. However, scientists noted some gaps in these ...
By CD Genomics
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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 non-NAFLD controls are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validation. Subjects are classified into three subgroups according to histological spectra of NAFLD or ...
By KoBioLabs
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