Mitochondrial Dna Articles & Analysis
4 articles found
The clinical sample types generally include fresh or frozen tissue that often yield high quality DNA and samples that often yield low quantity and/or compromised quality DNA like FFPE (formalin-fixed paraffin-embedded) tissue, decalcified FFPE tissue, bone marrow trephines, smears, and fine needle aspirates (FNA), plasma, and circulating tumor cells. Some studies ...
Mitochondrial DNA (mtDNA) encodes only 13 mitochondrial proteins, which are transcribed and translated within the mitochondria and become important protein components of the respiratory chain complex. mtDNA also encodes 2 ribosomal RNAs and 22 transfer RNAs, which can ensure the smooth expression of the respiratory chain complex proteins it ...
Here we report that 2-deoxyribonolactone (dL), a major type of oxidized abasic site, inhibits replication by mitochondrial DNA (mtDNA) polymerase and interferes with SP-BER by covalently trapping polymerase during attempted dL excision. ...
The genetic differentiation of the European lobster (Homarus gammarus) was investigated in 3,283 individuals from 44 population samples throughout its geographical distribution (Norway to Greece) by means of polymerase chain reaction restriction fragment length polymorphism analysis of a 3-kb mitochondrial DNA segment. Ninety composite haplotypes were revealed ...