Mitochondrial Protein Articles & Analysis: Older
6 articles found
They are responsible for several life-sustaining processes, including energy production, reducing free radicals, and maintaining cellular signaling. Proteins within the mitochondria play a key role in these processes.Why Sequence Mitochondrial ...
Mitochondrial DNA (mtDNA) encodes only 13 mitochondrial proteins, which are transcribed and translated within the mitochondria and become important protein components of the respiratory chain complex. mtDNA also encodes 2 ribosomal RNAs and 22 transfer RNAs, which can ensure the smooth expression of the respiratory chain complex ...
Abnormal expression of mitochondrial proteins is the main cause of their dysfunction. Mitochondrial proteomics analyzes the dynamic changes of protein composition, expression level and modification status of mitochondria from a holistic perspective, aiming to elucidate the expression and functional patterns of all ...
MSDC-0602K, a modulator of the mitochondrial pyruvate carrier (MPC), is in clinical trials as a potential treatment for NASH. Preclinical studies have shown that the mitochondrial pyruvate carrier is increased in expression in animals fed a high fat diet. Moreover, selective knockouts of each of the mitochondrial proteins that ...
The maturation of cytosolic iron-sulfur (Fe/S) proteins in mammalian cells requires components of the mitochondrial iron-sulfur cluster assembly and export machineries. ...
However, repair of dL was detected in human mitochondrial extracts, and we show that this repair is via long-patch BER (LP-BER) dependent on flap endonuclease 1 (FEN1), not previously known to be present in mitochondria. FEN1 was retained in protease-treated mitochondria and detected in mitochondrial nucleoids that contain known mitochondrial ...