molecular analysis Articles
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European collaboration in biotechnology: the molecular analysis of genomes
The new area of genome analysis has led to the rapid formation of large, well-funded international projects which are highly collaborative in nature. The research described here aims to improve our understanding of the research collaboration process through case studies of five genome projects. Large genome centres and extensive networks of small laboratories have adopted large-scale automated ...
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The role of internal node sequences and the molecular clock in the analysis of serially-sampled data
Algorithms that infer phylogenetic relationships between serially-sampled sequences have been developed in recent years to assist in the analysis of rapidly-evolving human pathogens. Our study consisted of evaluating seven relevant methods using empirical as well as simulated data sets. In particular, we investigated how the molecular clock hypothesis affected their relative performance, as three ...
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Molecular analysis of vibrio cholerae o1, o139, non-o1, and non-o139 strains: clonal relationships between clinical and environmental isolates
Rajiv Gandhi Centre for Biotechnology, Jagathy, Thiruvananthapuram 695 014, India; Center for Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 212022; Department of Cell and Molecular Biology, University of Maryland, College Park, Maryland 207426; School of Public Health, University of São Paulo, São Paulo, SP, 01246-904, São Paulo, Brazil; Department of ...
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Molecular analysis of vibrio cholerae O1, O139, non-O1, and non-O139 strains: Clonal relationships between clinical and environmental isolates
A total of 26 strains of Vibrio cholerae, including members of the O1, O139, and non-O1, non-O139 serogroups from both clinical and environmental sources, were examined for the presence of genes encoding cholera toxin (ctxA), zonula occludens toxin (zot), accessory cholera enterotoxin (ace), hemolysin (hlyA), NAG-specific heat-stable toxin (st), toxin-coregulated pilus (tcpA), and outer membrane ...
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Decoding the Language of Proteins: Insights from Molecular Dynamics Simulation
Molecular dynamics simulation is a powerful and widely employed computational method that investigates the motion and interactions of molecules under different conditions, revealing the structure, dynamics, and physical-chemical properties of molecules. This article aims to delve into the fundamental principles, applications, and key techniques of molecular dynamics simulation, providing you with ...
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Restriction Enzymes – Molecular Scalpels
The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes. The development of restriction endonucleases In the early 1960s, Werner Arber came up with the idea ...
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Molecular biology of autoinflammatory diseases
The lengthy battle between people and varied bodily, chemical, and organic insults that trigger cell damage (e.g., merchandise of tissue harm, metabolites, and/or infections) have led to the evolution of assorted adaptive responses. These responses are triggered by recognition of damage-associated molecular patterns (DAMPs) and/or pathogen-associated molecular patterns (PAMPs), normally by cells ...
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Prediction of chemotherapeutic response in ovarian cancer with DNA microarray expression profiling
Abstract Ovarian carcinoma is a leading cause of gynecologic cancer death in women. Despite treatment, a large number of women with ovarian cancer eventually relapse and die of the disease. Hence, recurrent ovarian cancer continues to be a therapeutic dilemma, possibly a result of the emergence of drug resistance during relapse. Recent advances in expression genomics enable global transcript ...
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Exploring ALS with AI Part II: Understanding familial and sporadic ALS
Part II: Understanding familial and sporadic ALS Welcome to our newest blog series where we investigate Amyotrophic Lateral Sclerosis (ALS) using our AI knowledge mapping tools. Check back for our next installment, in which we analyze transcriptomics from spinal cord samples collected from patients as well as a mouse model. In this second post in our Exploring ALS series, we will begin to dig ...
By PercayAI
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Multi-Site veterinary diagnostic laboratory uses Matrix Gemini LIMS for Seamless sample management case study
The Matrix Gemini Laboratory Information System (LIMS) from Autoscribe Informatics has been used to co-ordinate sample tracking, management and reporting across four different locations for a busy veterinary diagnostic and clinical pathology laboratory. Background Nationwide Laboratory Services Is a UKAS accredited independent multi-disciplinary veterinary laboratory providing diagnostic and ...
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Introduction to Microbiomics
Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...
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Introduction to Microbiomics
Microorganisms and their environment constitute a complex ecosystem, which is an important part of the biodiversity on earth. The microbiome refers to the collection of all microorganisms and their genetic information in a specific environment or ecosystem, and its connotation includes the interaction of microorganisms with their environment and host. Microbiomics is the study of the microbiome, ...
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CD Genomics Perspective: Practicing Genetic Marker Identification by Bulk Segregant Analysis
Introduction to Bulked Segregant Analysis BSA (bulked segregant analysis) is a method for identifying genetic markers linked to a mutant phenotype. Geneticists can use this information to find genes that confer disease resistance or susceptibility. Forming two groups with opposing phenotypes for a trait of interest is the goal of this technique. Individuals in one group, for example, are disease ...
By CD Genomics
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Understanding Drug-Disease Relationship Analysis: A Key to Drug Discovery
In the realm of modern medicine, the quest for new and effective drugs to combat various diseases is a continuous journey. Drug discovery, the process of identifying compounds that can potentially treat diseases, has seen a significant transformation in recent years, thanks to advancements in computational biology and artificial intelligence (AI). In this article, we will delve into the ...
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Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology
Introduction Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture technology to enrich DNA from the whole exome regions, enabling high-throughput sequencing. WES offers a simpler, more cost-effective, ...
By CD Genomics
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Protein N-Glycosylation Analysis Strategy and Procedures
The glycan chain is located in the outermost layer of the cell and is the first molecule encountered and recognized by other cells, antibodies, invading viruses and bacteria. N-glycans regulate a wide range of cellular functions, including cell-cell and cell-matrix adhesion, cell proliferation, cell survival and immune system response, by affecting protein folding, recognition, clearance, ...
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