monoclonal antibody development Articles
-
Tumor Glycan-Targeted Therapy
Glycosylation is a sophisticated type of post-translational modification that impacts over 50% of cellular proteins and is a critical regulator of many eukaryotic processes. Aberrant glycosylation is a common hallmark of many malignancies and is important at all stages of tumor growth. Glycosylation regulates a range of physiopathological processes, including cell-cell adhesion, cell-matrix ...
-
An Introduction of Intact Mass Analysis - Protein Characterization by Mass Spectrometry
As the field of biotechnology continues its inexorable march towards unfathomable frontiers, the characterization of proteins emerges as a critical linchpin in this progressive process. In this context, intact mass analysis by mass spectrometry serves as an indispensable tool of the trade, empowering researchers to achieve a thorough understanding of these enigmatic molecules. Intact mass ...
-
Antibody-Drug Conjugates: New Strategies of ADC Payloads
The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal antibodies, that the era of ADC drug development truly began. Driven by increasingly mature technology, ADC drugs have gone through three iterations (Fig. 1). Although ADCs have gone through three iterations, current ...
By BOC Sciences
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you