nervous system Articles
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Circadian variation of cardiac autonomic nervous profile is affected in Japanese ambulance men with a working system of 24-h shifts
Object: The purpose of this study was to compare the stress levels of Japanese ambulance men between on-duty and off-duty days, by using the physiological indices of heart rate variability (HRV) and cortisol in urine, measured over each 24-h period. Methods: Measurements were made during one on-duty and one off-duty day for each subject. The participants were monitored for 24 h with a Holter ...
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Design of a biomimetic-based monitoring and diagnostic system for civil structures
Recent high intensity natural events such as hurricanes, tsunamis, and earthquakes have introduced new challenges for the design, maintenance, and sustainability of civil structures. Globally, civil infrastructures are deteriorating at an alarming rate caused by overuse, overloading, aging, damage or failure due to natural or man-made hazards. With such a vast network of deteriorating ...
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The Parasym Device? Significantly Increases Parasympathetic Activity?
Autonomic Balance The parasympathetic nervous system (PNS) and sympathetic nervous system (SNS) both work in balance and together make up the autonomic nervous system (ANS), which is responsible for many of the bodies autonomic (unconscious) processes. The parasympathetic system has been referred to as 'rest and digest' and the sympathetic system to that of 'fight or flight'. Activating the PNS ...
By Parasym Ltd.
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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
We report here the characterization of a mutant mouse line with a specific gene trap event in the Mdm4 locus. Absence of Mdm4 expression results in embryonic lethality (10.5 days postcoitum [dpc]), which was rescued by transferring the Mdm4 mutation into a Trp53-null background. Mutant embryos were characterized by overall growth deficiency, anemia, improper neural tube closure, and dilation of ...
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Cross talk between notch and growth factor/cytokine signaling pathways in neural stem cells
Precise control of proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for proper development of the nervous system. Although signaling through the cell surface receptor Notch has been implicated in many aspects of neural development, its role in NSCs remains elusive. Here we examined how the Notch pathway cross talks with signaling for growth factors and ...
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Building effective institutional frameworks to support pharmacogenetic research: an international empirical analysis
As science unravels the genetic basis of disease, the opportunities offered by pharmacogenetics and pharmacogenomics (PGx) for future healthcare become more and more apparent. The objective of this paper is to analyse the current state of PGx research and explore future strategies for more efficient research projects and supportive infrastructures. Based on internet searches and an online survey ...
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Application of refractable nanocomposite on cell based therapy in central nervous system
Quantum Dots (QDs) are nano–particles carrying high stability fluorescence to follow the grafted cells which can be used in investigating the movement of cells and understanding the organogenesis of stem cells during development and wound repair processes in adulthood. For its easy acquirement and bypassing moral ethical issues, it makes the human adipose derived stem cells an attractive, ...
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Essential role for epidermal growth factor receptor in glutamate receptor signaling to nf-b
Glutamate is a critical neurotransmitter of the central nervous system (CNS) and also an important regulator of cell survival and proliferation. The binding of glutamate to metabotropic glutamate receptors induces signal transduction cascades that lead to gene-specific transcription. The transcription factor NF-B, which regulates cell proliferation and survival, is activated by glutamate; ...
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Acute exposure to DE‐71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae
The aim of the present study was to investigate the acute developmental neurotoxicity of polybrominated diphenyl ethers (PBDEs) in zebrafish larvae. From 2 to 120 h postfertilization Zebrafish embryos at were exposed to DE‐71 (0, 31.0, 68.7, and 227.6 µg/L). We studied the locomotor behavior of larvae, involvement of the cholinergic system, and selected gene and protein expressions in the central ...
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Absorption, distribution, and biotransformation of hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine (RDX) in B6C3F1 mice (Mus musculus)
Absorption, distribution, and biotransformation are three critical aspects affecting toxicant action in animals. In this study, B6C3F1 mice (Mus musculus) were exposed for 28 days to contaminated feed that contained one of five different RDX concentrations: 0, 0.5, 5, 50, 500 mg/kg. RDX (Hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine) and its reductive transformation products: MNX ...
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Chemyx Syringe Pumps in Neuroscience Research
Introduction The classical field of neuroscience entails biological or psychological investigation of the nervous system, including the brain, spinal cord and the systemic network of sensory nerve cells called neurons.1 Traditionally, this field comprised of purely biological studies but has since flourished into an interdisciplinary sphere addressing the developmental, physiological, ...
By Chemyx Inc
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Regulation of cancer by therapeutic vaccination and dietary bio-modulation involving organ-specific mitochondria
Cancer therapy should aim to prevent recurrent disease. Surgery and toxic treatments remove only symptoms associated with cancer without trying to intervene in the aetiology, therefore the disease may recur. The autologous cancer vaccine supplemented with bio-modulation might fulfil requirements for effective tumour therapy. The autologous tumour vaccine is formed in the same way as our bodily ...
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Prominent Names in RNA Delivery Discuss What’s Around the Corner
Oxford Global kicked off another exciting discussion group all about RNA therapeutics and emerging technologies for their delivery. Those attending were experts from the leading authorities in the field. Leading the conversation was Susan Rosenbaum, Founder, Chairman, and CEO of Lauren Sciences, a company that has been the recipient of twelve foundation grant awards and won first prize for Global ...
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Vitamins: Types and Their Functions
Vitamin A: Helps body growth and tissue repair, helps with eye health, fights bacteria to avoid infection, protects epithelial tissue health, and promotes bone and tooth development. Vitamin B1: Promotes the metabolism of carbohydrates, maintains a healthy nervous system, stabilizes appetite, stimulates growth and maintains good muscle condition. Vitamin B2: Promotes the metabolism of ...
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Looking to the Future of Neuro Devices: Exclusive Interview with Alcyone Lifesciences CEO PJ Anand
Alcyone Lifesciences is a medical technology company based out of Lowell, MA, which specializes in central nervous system (CNS) drug delivery platforms for targeted infusions of the brain or spinal cord. Their Thecaflex DRx System was recently awarded Breakthrough Device designation by the FDA, for spinal infusion of therapeutic medications. Medgadget had the opportunity to speak with Alcyone ...
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The Vagus Nerve - What is it and why is it so important to our health?
Key points The vagus nerve controls many unconscious processes in the body The vagus neural network interfaces with inflammatory, mood and pain regulation. This can be utilised for its neuromodulatory effect in activating restorative pathways. The vagus nerve has been called the ‘great wandering protector’ of the body, it’s made up of an intricate neural network that ...
By Parasym Ltd.
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Platform technologies to support brain-computer interfaces
There is a lack of adequate and cost-effective treatment options for many neurodegenerative diseases. The number of affected patients is in the millions, and this number will only increase as the population ages. The developing areas of neuromimetics and stimulative implants provide hope for treatment, as evidenced by the currently available, but limited, implants. New technologies are emerging ...
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Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration
School of Biological Sciences, The University of Hong Kong, Hong Kong, China. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, Hong Kong, China. School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, ...
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Fibromyalgia Therapies and Treatments
In honor of National Fibromyalgia Awareness Day this month, we are doing our part to set the record straight on Fibromyalgia, a condition the MayoClinic calls “one of the most misunderstood disorders in medicine today.” Once thought to be an autoimmune or inflammatory disorder, specialists now agree that fibromyalgia is a disorder of the nervous system. It most commonly affects women ...
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OCD: an "autoimmune disease"
Obsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a multifactorial disorder with an interplay of biological, psychological, and external factors, and ...
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