Neurological Diseases And Disorders Articles & Analysis
30 articles found
The stability of tRNA molecular conformation together with genome translation efficiency depend on this modification. Many diseases including neurological disorders and tumors result from defective tRNA methylation. ...
Optogenetics has emerged as a transformative tool in the field of neuroscience, allowing researchers to manipulate neuronal activity with unprecedented precision. At the heart of this technology lies the use of adeno-associated viruses (AAVs), which serve as robust delivery vehicles for light-sensitive proteins into targeted neuronal populations. This article delves into the significance of ...
Understanding the deep connection between Lipid Metabolism and these hormones, along with the importance of precise Steroid Hormone Analysis, opens a window into our health, development, and disease. At its core, Lipid Metabolism encompasses the intricate biochemical processes involved in the synthesis, breakdown, and transport of fatty acids, cholesterol, and other lipid ...
Central Nervous System APIs address neurological and psychiatric conditions by modulating neurotransmission, receptor function, and neural signaling pathways. ...
The Importance of HA-c Research using HA-c has illuminated several key aspects of cerebellar function and its involvement in neurological diseases. These astrocytes maintain the integrity of the blood-brain barrier, regulate neurotransmitter levels, and provide metabolic support to neurons. ...
They have applications in basic biology research, as well as in fundamental processes for drug discovery, disease modeling, regenerative medicine, and personalized treatment approaches. ...
Disruptions in these controls can lead to uncontrolled cell division, a hallmark of cancer and other diseases. Cell cycle progression is orchestrated by key proteins, including cyclins, cyclin-dependent kinases (CDKs), and tumor suppressors. ...
They are implicated in a wide range of conditions, from cardiovascular and metabolic disorders to neurological diseases and cancers. By facilitating the early stages of the drug development pipeline, GPCR Screening Services help streamline the identification of lead compounds, optimizing the chances of successful therapeutic outcomes. ...
Benefits and advantages of iPSC differentiation to neural stem cells (NSC), neurons and glial cells: Provides genetic and physiologically relevant in vitro models to study neural development and associated disorders: congenital disorders, neurodegenerative disorders and brain tumors. Generates a valuable model for identifying new targets for ...
Candidate drugs like ARV110 and ARV-471 have entered Phase I/II clinical trials, indicating the potential of PROTACs in the treatment of cancer and other diseases. The high selectivity, resistance-overcoming capabilities, and ability to target previously undruggable proteins make PROTACs effective in various diseases, including neurological ...
CD Genomics, a well-established leader in transcriptome solutions, is pleased to announce the introduction of Ribosome Profiling technology. This innovative technique promises to provide valuable insights into gene expression, protein synthesis, and regulation, offering potential advancements in the field of RNA translation research. Ribo-seq is a cutting-edge high-resolution sequencing ...
Their immune-modulatory abilities make them a sought-after tool in treating autoimmune diseases, while their differentiation potential is harnessed for tissue repair and regeneration. In a clinical context, MSCs are instrumental in treating osteoarthritis, inflammatory bowel disease, graft-versus-host disease, myocardial infarction, and more. ...
Chimeric RNAs have been observed in various organisms, including humans, and have been found to play a role in a variety of diseases, particularly cancer. They can contribute to tumorigenesis by generating abnormal proteins or disrupting normal cellular processes. Chimeric RNAs have also been implicated in other diseases, such as neurological ...
It contributes extensively to the understanding of the physiological function of ionic channels in health and disease. From exploring their roles in some neurological disorders, cardiovascular diseases to electrolyte imbalance—it's a resourceful tool. ...
More than a dozen viral gene therapy products have been approved for the treatment of cancer, infectious diseases, and rare single-gene disorders. The main types of viral vectors used clinically for in vivo gene therapy include adenovirus, adeno-associated virus (AAV), herpes simplex virus (HSV), retroviruses, and lentiviruses. ...
In late November, EpiFinder Co-Founder Neel Mehta and Creative Officer Kristi Kietzmann left Arizona for a cross-country road trip. The journey from Arizona to Washington D.C. covered 5,504 miles over 22 days. At Washington D.C., CEO Robert Yao and other team members joined them for the 71s American Epilepsy Society (AES) conference. There, the team held 3 days of exhibits and presented. Why ...
Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene regulation. Diseases And Epigenetic Modifications The occurrence of some diseases has been found to be inextricably linked to epigenetics. ...
Several improvements support the hypothesis that dynamic standing using the Innowalk is effective as an add-on to standard therapy in the treatment of children and young people with severe motor impairments. The study included 46 patients where 50% were diagnosed with cerebral palsy and 50% with diverse syndromes. The results show improvements on: Passive assisted motion (79%) Stimulation ...
The discovery could lead to better new treatments for neurological disorders such as anxiety, autism spectrum disorder, schizophrenia and Parkinson's disease. In determining the structure of this transporter, one of the smallest proteins ever made, researchers have opened up new avenues to improve drugs for a variety of ...
The relationship between lncRNAs and diseases is well established, especially in chronic disorders. However, cancer is one of the most intensively studied diseases associated with lncRNAs. ...