neurological disorder Articles
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Oxygen therapy for neurology
A prematurely aged brain has suffered years of abuse from our ever-increasingly toxic environment and unhealthy lifestyles. There is extensive research that shows HBOT may have an effect in rejuvenating a patient’s brain by stimulating the production of new blood vessels. Increased oxygen in the blood flow will re-energize dormant cells in the brain and create new ones. Oxygen to ...
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Zika Virus: WHO announces a Public Health Emergency of International Concern
The first meeting of the Emergency Committee (EC) convened by the Director-General under the International Health Regulations (2005) (IHR 2005) regarding clusters of microcephaly cases and other neurologic disorders in some areas affected by Zika virus was held by teleconference on 1 February 2016. According to the Pan American Health Organization the Zika illness is caused by the bite of an ...
By SafetyNow
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An open letter to the neuro-community: The need for a roundtable approach to manage neurodisorders during COVID-19
1 billion people around the world are currently suffering from neurological disorders, and the number is growing by the day. The COVID-19 pandemic has had a significant negative impact on the healthcare system’s ability to effectively diagnose and treat these individuals. However, despite the growing numbers, action has not been taken by world leaders, creating a huge unmet need. This ...
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Structure-based Design of Protein Kinase Inhibitors
Protein kinases are effective anti-cancer drug targets that have been proven in many experiments and facts. Many small molecule protein kinase inhibitors approved by the FDA can be used for cancer treatment. The effectiveness of kinases as targets for other diseases, including neurological disorders, inflammation and metabolic diseases, is also being tested. Human protein kinase consists of more ...
By BOC Sciences
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A Small Protein May Help People with Epilepsy and Other Diseases
For the first time, scientists have elucidated the structure of GABA transporter 1 (GAT-1) using cryo-electron microscopy. The discovery could lead to better new treatments for neurological disorders such as anxiety, autism spectrum disorder, schizophrenia and Parkinson's disease. In determining the structure of this transporter, one of the smallest proteins ever made, researchers have opened ...
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Unveiling The Manifold Potentials: Mesenchymal Stem Cells & Bone Marrow Mesenchymal Stem Cells
In the vibrant realm of cellular biology and regenerative medicine, mesenchymal stem cells (MSCs) hold unparalleled potential for therapeutic applications. Particularly noteworthy are bone marrow mesenchymal stem cells (BM-MSCs), a subtype of MSCs. Their unique properties make them indispensable resources for developing ground-breaking solutions for various medical conditions. Mesenchymal stem ...
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Unlocking the Possibilities of Customized Ionic Channel Expression Systems
Ionic channels, which are proteins present in the membranes of all living cells, are gaining significant importance in the fields of bio-medicine and biotechnology. They are responsible for the transmission of signals across cell membranes and are instrumental in multiple biological processes. This raises the demand for a systematic mechanism that can control their expression. The customized ...
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Oliver Sacks: the patient-focused polymath
A man sits on a stage and begins to speak. He is humble and soft spoken; he talks tenderly about a patient of his – an elderly lady in a home who had started to hallucinate. He recalls the story of how he diagnosed her, smiling as he retells the lady’s jokes and remembers how happy she was to understand what was happening to her. The man is Dr. Oliver Sacks, a world-renowned ...
By Elsevier B.V
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
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Development of Gene Therapy Viral Vectors for Rare Diseases
In many cases, gene therapy requires a vector to deliver the gene therapy drug to the target cell. Viral vectors have been one of the most widely studied vectors due to their outstanding transduction efficiency and other significant advantages. Viral vector-based gene therapy has now achieved good clinical results. More than a dozen viral gene therapy products have been approved for the treatment ...
By Protheragen
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CD Genomics Takes Genomic Research to New Heights with Ribo-seq Technology
CD Genomics, a well-established leader in transcriptome solutions, is pleased to announce the introduction of Ribosome Profiling technology. This innovative technique promises to provide valuable insights into gene expression, protein synthesis, and regulation, offering potential advancements in the field of RNA translation research. Ribo-seq is a cutting-edge high-resolution sequencing ...
By CD Genomics
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A Fitbit for your Brain is Around the Corner
A woman reads a book while attached to an EEG machine at the University of Bonn's Department of Epileptology in Bonn, Germany on July 16, 2000. The technology can gather brain wave data in daily life situations rather than clinical settings, which holds promise for researchers of neurological disorders. Every time you blink, think or move, your brain generates electricity as individual neurons ...
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Ion Channel Screening & Profiling: Unlocking a New Dimension in Drug Discovery
In the realm of drug discovery, researchers are constantly striving to unlock new possibilities for the treatment of diseases. One crucial aspect of this endeavor is the understanding and exploration of ion channels - integral membrane proteins that regulate the flow of ions across cell membranes. These channels play a fundamental role in numerous physiological processes and are essential targets ...
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Array-based Methylation Detection Explores the Mysteries of Cancer
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. Thereby, those changes include DNA methylation, histone modifications and non-coding RNAs. affects gene ...
By CD Genomics
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LncRNA Sequencing Helps to Find Deep Links to Disease
Long non-coding RNAs (lncRNAs) are a class of RNAs that do not code for proteins and are typically greater than 200 nucleotides in length. Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. Therefore, those ...
By CD Genomics
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Chimeric RNA and Sequencing Technologies: Advancing Detection and Research
What is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts play a significant role in diverse ...
By CD Genomics
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The Liposome-Based PROTAC Strategy
Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system exhibits selective degradation of target proteins, with folate serving as a key ligand. In this study, the ...
By BOC Sciences
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How Whole Exome Sequencing Works: Principles and Workflow Demystified
As the development of biological experimental technology, especially gene-sequencing technology, both laboratory and clinical researchers realize that genome sequencing is the best way to analyze the etiology, pathophysiology, treatment and prognosis of diseases. Researches further demonstrate that there are only 30 million base pairs of genes that contain essential information of proteins for ...
By CD Genomics
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Betting big on quantitative neurobiomarkers
Introducing Beacon Biosignals: a neurotechnology company founded to develop machine learning-enabled EEG neurobiomarkers and accelerate precision medicine for any disease state affecting the brain Founded by MD/PhDs and engineers from Harvard and MIT, Beacon is propelled by the vision of a computing platform designed to scale the interrogation of large brain datasets with unprecedented ...
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EpiFinder Takes a 5,504-Mile Road Trip to Share Its Mission
In late November, EpiFinder Co-Founder Neel Mehta and Creative Officer Kristi Kietzmann left Arizona for a cross-country road trip. The journey from Arizona to Washington D.C. covered 5,504 miles over 22 days. At Washington D.C., CEO Robert Yao and other team members joined them for the 71s American Epilepsy Society (AES) conference. There, the team held 3 days of exhibits and presented. Why ...
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