non-alcoholic steatohepatitis Articles
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How the Emerging NAFLD-NASH Crisis Underscores the Urgent Need for Better Diagnostics
With NAFLD and NASH now affecting well over 1 billion people globally, the world needs better diagnostics to accurately detect liver disease in an affordable, easy-touse and safe manner. Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) and its inflammatory stage, Non-Alcoholic SteatoHepatitis (NASH), are now a global healthcare crisis, and the facts should frighten patients, healthcare ...
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MRE plus FIB-4 (MEFIB) versus FAST in detection of candidates for pharmacological treatment of NASH-
Abstract Background and aim: Nonalcoholic fatty liver disease (NAFLD) patients with significant hepatic fibrosis (stage ≥ 2) are at increased risk of liver-related morbidity and are candidates for pharmacologic therapies. In this study, we compared the diagnostic accuracy of MEFIB (the combination of magnetic resonance elastography [MRE] and FIB-4) and FAST (FibroScan-AST; combined liver ...
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Project - Sublingual Dual Incretin Inhibitor (GLP-1/GIP)
Biolingus explores the development of a sublingual dual incretin inhibitor. BioLingus will position these products in the “epidemic” markets of obesity and type II diabetes : More than 400 MM people suffer from diabetes today. The global type 2 diabetes market is expected to grow to $58.7 billion by 2025, with an annual growth rate of 6.5%, according to research and consulting ...
By BioLingus AG
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Move over Saudi Arabia. Here comes Nash and his Dad!
As a parent, I don’t expect world changing results when I gripe at my kids. I’m happy if they at least leave a path through the dirty clothes on their bedroom floors. If you’re like that too, you’ll be a little sheepish when you hear the story of inventor and journalist Pierce Hoover. His 13-year-old son, Nash, kept forgetting to shut off the lights, so Hoover made a very ...
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Barge Nash Salvage Response - Case Study
The 260’ long barge NASH, loaded with magnesium chloride in an aqueous solution, essentially a by-product of solar desalinization, was part of a tandem tow between Mexico and Canada. The barge sank in the vicinity of Point Conception, just off the rugged California coastline near Santa Barbara. With a specific gravity of 1.3, magnesium chloride is much heavier than water. This prevented ...
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A human in vitro three-dimensional bioprinted liver tissue system can be used to model nutritional damage and protective effects of MSDC-0602K, a novel modulator of the mitochondrial pyruvate carrier (MPC)
Publication Summary: The growing global incidence of NASH mirrors the availability of nutrients. Over-nutrition also results in insulin resistance and type-2 diabetes, which are often co-morbidities associated with NASH and are known to drive more adverse outcomes. MSDC-0602K, a modulator of the mitochondrial pyruvate carrier (MPC), is in clinical trials as a potential treatment for NASH. ...
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Overview Of SFA Therapeutics
SFA Therapeutics’ CEO Dr Ira Spector presents an overview of the company and its platform technology SFA Overview Presentation on YouTube Introduction to SFA Liver Disease and Oncology Programs. SFA Oncology More information here We received US Patent 10,143,669B2; to prevent Hepatitis B progression to HCC, a liver cancer that affects 400 million patients and causes 1 million cancer ...
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Modeling NAFLD using 3D bioprinted human liver tissue
Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver disease in the western world, with an ...
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Modeling NAFLD using 3D bioprinted human liver tissue
Publication Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition that originates as lipid accumulation within hepatocytes (steatosis) and progresses into nonalcoholic steatohepatitis (NASH), characterized by lipid accumulation, inflammation, oxidative stress, and fibrosis. NAFLD is now recognized as the most common cause of chronic liver disease, with a prevalence of 25% ...
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Degradation of splicing factor SRSF3 contributes to progressive liver disease
Abstract Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), ...
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