oral activated Articles
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Abstract 10306: Identification and Characterization of Orally Bioavailable Small Molecule Protease Proprotein Convertase Subtilisin-like Kexin Type 9 Inhibitors (Best of Basic Science Abstract)
Abstract Intervention with drugs to reduce low density lipoprotein-cholesterol (LDL-C) has proven to decrease mortality and morbidity. Here, we report the development of small molecules that lower LDL-C by targeting the LDL-receptor (LDLR) degradation pathway, which is modulated by the protease proprotein convertase subtilisin-like kexin type 9 (PCSK9). PCSK9 is synthesized as a 72-kDa zymogen ...
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Structural model of polymeric nanospheres containing indomethacin ethyl ester and in vivo antiedematogenic activity
The aim of this work was to establish a structural model for describing the organisation, at a molecular level, of nanospheres prepared by nanoprecipitation using poly(ε-caprolactone), sorbitan monostearate and polysorbate 80. Therefore, different techniques were employed to characterise the systems such as dynamic and static light scattering, small angle X-ray scattering and release profile ...
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Monitoring gastric myoelectric activity after pancreaticoduodenectomy for diet "readiness
Abstract Postoperative delayed gastric emptying (DGE) is a frustrating complication of pancreaticoduodenectomy (PD). We studied whether monitoring of postoperative gastric motor activity using a novel wireless patch system can identify patients at risk for DGE. Patients ( n = 81) were prospectively studied since 2016; 75 patients total were analyzed for this study. After PD, battery-operated ...
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Fresenius Kabi Oncology Ltd - Case Study
Name: Imran Ahmed Job Title: Senior Research Scientist Company: Fresenius Kabi Oncology Ltd., Gurgoan, India Imran Ahmed, Senior Research Scientist, Fresenius Kabi Oncology Ltd Fresenius Kabi Oncology, performing with Precision Fresenius Kabi Oncology Ltd. primarily operates in the field of research and development, as well as manufacturing, of world-class oncology drugs. The company aims ...
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The Effect of Probiotics for the Gut Health
There are trillions of microbes inhabiting the human intestine. These microbes gradually reach a balance of types and numbers during the process of reproduction, and this balance is closely related to the body's normal metabolism. Once the structure of the intestinal flora becomes imbalanced, various metabolic diseases will follow. The probiotics multiply in large quantities in the intestine, ...
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