oral delivery Articles
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Microencapsulation of bacteriophage felix o1 into chitosan-alginate microspheres for oral delivery
This paper reports the development of microencapsulated bacteriophage Felix O1 for oral delivery using a chitosan-alginate-CaCl2 system. In vitro studies were used to determine the effects of simulated gastric fluid (SGF) and bile salts on the viability of free and encapsulated phage. Free phage Felix O1 was found to be extremely sensitive to acidic environments and was not detectable after a ...
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Novel nanoplatform for oral delivery of anti–cancer biomacromolecules
Oral administration of bio–macromolecules is an uphill task and the challenges from varying pH and enzymatic activity are difficult to overcome. In this regard, nanotechnology promises the new hope and offers advantages such as controlled release, target specific delivery, combinatorial therapy and many more. In this study, we demonstrate the formulation of a novel alginate enclosed, chitosan ...
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Nanoparticulate systems for oral drug delivery to the colon
A review of oral drug delivery to the colon is a difficult but desirable method of administration. In order to target the colon the dosage form must overcome the barriers presented by the gastrointestinal tract including the steep pH gradient, binding to the mucus layer, premature clearance, and premature cellular uptake. Nanoparticles have been fabricated via a number of methods and designed ...
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Rani developing technology for oral delivery of injectable biologics
(NASDAQ:RANI) is developing a disruptive technology to solve the problem of converting biologic injectable drugs, including antibodies, peptides and proteins, into oral therapies with its RaniPill that bypasses destruction in the stomach to deliver its payload to the vascular intestinal wall in the GI tract. “This is not a new idea, although previous attempts were based on chemistry and ...
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Sildenafil citrate nanoemulsion vs. self-nanoemulsifying delivery systems: rational development and transdermal permeation
Sildenafil citrate (SC) is the first choice drug for erectile dysfunction. Nevertheless, drug oral delivery is hampered by some obstacles including first pass metabolism, numerous side effects, relatively short duration and long onset of action. Furthermore, drug delivery formulation and transdermal application of SC is challenged by its amphoteric nature, low oil and water solubility, ...
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Protein-loaded chitosan nanoparticles modulate uptake and antigen presentation of hen egg-white lysozyme by murine peritoneal macrophages
Chitosan binds to negatively charged tripolyphosphate (TPP) by an electrostatic interaction driven by its positively charged amino group. This interaction allows developing stable nanoparticles suitable as a carrier and controlled release system for drugs and vaccines. We study the effect of chitosan nanoparticles (CNp) on the uptake and antigen presentation of the model protein hen-egg white ...
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SmartTab Completes Gastric Environment Validation Study for InjectTab™ Platform
What if you were able to simply take a pill to receive the medication you’re used to receiving through a shot, like insulin? As a leading innovator and disruptive drug delivery company, SmartTab is driving the future of drug delivery to places people would have never expected it to go and injections with a conventional syringe and needle will soon be a thing of the past. SmartTab's ...
By SmartTab
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Applications of Liposomal Drug Delivery System Technology
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, ...
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Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for ...
By BOC Sciences
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The role of nanotechnology in diabetes treatment: current and future perspectives
Diabetes is a chronic disease that currently affects approximately 8% of the US population, and that number is expected to increase significantly by the year 2030. It is imperative that effective monitoring and treatment options be available to patients. Nanotechnology is a focal point in diabetes research, where nanoparticles in particular are showing great promise in improving the treatment and ...
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Sink your teeth into a virtual issue on oral health
A new free-to-read Australian Journal of Primary Health virtual issue addresses various aspects of oral healthcare, including access, vulnerable groups and new models of service delivery. Our teeth are one of our most important assets, yet perhaps the most neglected area when it comes to looking after our health and well being. A new Australian Journal of Primary Health virtual issue highlights ...
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