pancreas Articles
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Jerusalem firm in funding bid to test ‘micro-pancreas’ on humans
An implantable ‘micro-pancreas’ with the ability to produce insulin in response to blood glucose levels has been created by Israeli scientists. Betalin Therapeutics has tested the technology on animals with some success and is now looking to raise enough funds to be able to put it through clinical trials. It combines cells and a biological scaffolding, which situates those cells and ...
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Suppressive effect of low-dose X-irradiation on type I diabetes non-obese diabetic (NOD) mice
We examined the effect of X-irradiation (0, 0.25, 0.5 or 1.0 Gy) on the onset of the type I diabetes (insulin dependent diabetes mellitus) in non-obese diabetic (NOD) mice. NOD mice are characterised by a progressive loss of insulin-producing β-cells in the pancreas by autoimmune mechanisms. The destruction of β-cells is known to be due to apoptosis induced by oxidative stress caused by ROS. In ...
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Absorbed dose using a nanoscale ion beam for Bragg peak calibrations
The proton beam was investigated for cancer cell therapy in the pancreas. Neon ion interaction profiles were compared with the result of the proton beam, which was investigated for nanoscale ion beam interactions. Simulation for the Bragg peak calculation was performed for interactions with a human organ, the pancreas. The results show the absorbed dose and dose equivalent, which vary with the ...
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Phase lb study of venadaparib, a potent and selective PARP inhibitor, in homologous recombination repair (HRR) mutated breast cancer
Poly ADP-ribose polymerase (PARP) is an enzyme that is central to the repair of DNA replication errors and are currently approved for ovary, breast, pancreas and prostate cancers. VASTUS study (NCT04174716)1' is a basket trial investigating the safety and efficacy of venadaparib in 6 cohorts (active recruiting) of different tumors, including breast ...
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Transcriptional autoregulation controls pancreatic ptf1a expression during development and adulthood
The basic helix-loop-helix (bHLH) transcription factor PTF1a is critical to the development of the embryonic pancreas. It is required early for the formation of the undifferentiated tubular epithelium of the nascent pancreatic rudiment and then becomes restricted to the differentiating acinar cells, where it directs the transcriptional activation of the secretory digestive enzyme genes. Here we ...
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Molecular differences and fingerprinting of normal and genetically engineered 'Saccharomyces cerevisiae' human insulin producer
The purpose of the present paper is an attempt to determine the molecular differences and fingerprinting of a normal and genetically engineered Saccharomyces cerevisiae human insulin producer obtained through transformation with human DNA (introns and exons) isolated from healthy human pancreas. Five primers were used; four with 20-mer and one with 10-mer. Gels photographs for all primers using ...
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Israeli artificial pancreas may one day cure diabetes
The Engineered Micro Pancreas from Betalin Therapeutics is heading closer to clinical trials in humans. Ahead of International Diabetes Day, November 14, Israeli startup Betalin Therapeutics announced that it is beginning the application process for clinical trials of its revolutionary artificial pancreas. Betalin’s Engineered Micro Pancreas (EMP) aims to free patients suffering from the ...
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Israeli scientists: Cure for insulin-dependent diabetics within five years
A team of Jerusalem-based researchers and entrepreneurs claim they have a cure for diabetesthat could hit the market as early as within the next few years. Betalin Therapeutics has developed the first bio-artificial pancreas, composed of pig’s lung tissue and insulin secreting cells. The artificial pancreas would be implanted into the patient and connect with his or her blood vessels, ...
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The role of nanotechnology in diabetes treatment: current and future perspectives
Diabetes is a chronic disease that currently affects approximately 8% of the US population, and that number is expected to increase significantly by the year 2030. It is imperative that effective monitoring and treatment options be available to patients. Nanotechnology is a focal point in diabetes research, where nanoparticles in particular are showing great promise in improving the treatment and ...
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Why Supplementing Digestive Enzymes Is Necessary for Most People?
Enzymes are proteins with catalytic functions in organisms. The distinguishing feature of enzymes is that they have a high degree of catalytic function and specificity, and the activity of enzymes can be adjusted, which is closely related to the conversion of different energy forms. Up to now, there are nearly 2,000 known enzymes. Digestive enzyme is one of them. It is mainly secreted by the ...
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Efficient Wastewater cleaning for Insulin Production
Insulin production using biotechnology is now a standard procedure, but it leads to a high level of contaminated wastewater due to tensides which are difficult to break down. A solution provided by EnviroChemie shows how production wastewater output with varying levels of contamination and toxicity can be cleaned efficiently. It combines aerobic and anaerobic steps as well as a low-temperature ...
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The Reality of Diabetes Reversal
The conversation around diabetes reversal has increased, and when researching diabetes there are numerous states to this claim, but how realistic is it? Sadly, diabetes affects a huge number of people worldwide and is responsible for blindness, kidney disease, limb amputation and death. WHO estimates that diabetes was the seventh leading cause of death in 2016[1] and 422 million adults currently ...
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Development of a Bioartificial Vascular Pancreas
Abstract Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased ...
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Classification and Function of Amylase
Amylase (AMS), also known as 1,4-α-D-glucanohydrolase, is a general term for enzymes that hydrolyze starch and glycogen. The main function of amylase is to break down starch to produce simple sugars such as fructose, maltose, glucose and dextrin. Amylases are also used in food and beverage processing and other industries. Classification of amylases 1. Alpha-amylase Alpha-amylase is mainly ...
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Diabetic Burnout: What is it & how can we help ourselves?
Diabetes is a chronic health condition that affects how your body turns food into energy. Most of the food you eat is broken down into sugar and released into your bloodstream. When your blood sugar goes up, it signals your pancreas to release insulin. Insulin acts like a key turning on cells with sugar as fuel (energy). Diabetes affects your body’s ability to produce or use that insulin. ...
By EO2 Concepts
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Detailed Introduction to Clinical Significance of Amylase
As a kind of enzymes for diagnostic use. Serum amylase (AMS) is the main type of amylase in serum. It belongs to glycoside chain hydrolase, which is mainly derived from the pancreas. In addition, there are also a small amount of secretion in the proximal duodenum, lung, uterus, and breast during lactation. Amylase plays an important role in the digestion of polysaccharide compounds in food. The ...
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Bioreactors For Pharmaceuticals
The Use of Bioreactors In The Pharmaceutical IndustryThe pharmaceutical industry relies heavily on bioreactors to support a wide range of biological research applications, from cell therapy to vaccine development.1 These bioreactors provide a controlled environment for the growth of microorganisms, such as bacteria, cells, and algae, in order to produce biomolecules or biomaterials used in ...
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Everything You Want to Know About Alkaline Protease
Alkaline protease is a serine proteolytic enzyme in endopeptidases, which can hydrolyze protein peptide bonds under alkaline conditions, and its optimal pH range is 9-11. It is mainly used in the enzyme detergent industry, and it is also widely used in industries such as tanning, silk, feed, medicine, food, and environmental protection. This enzyme was first found in the pancreas of pigs. At ...
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How to support healthy blood sugar levels.
Healthy blood sugar levels are important for everyone. Maintaining healthy blood sugar levels can help reduce the risk of developing diabetes, kidney dysfunction, and problems with your eyes, gums, and nerves. Day-to-day healthy blood sugar levels will help with balancing energy levels, maintaining focus, and stabilizing mood. What Is “Blood Sugar?” Blood sugar, also known as ...
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How to Know if your Blood Sugar is Low
If you go to a doctor regularly, and you should, more than likely you have had your blood tested for sugar levels. A high blood sugar or glucose level can be an indicator for the onset of prediabetes or diabetes. Too much sugar for anyone of any age can be dangerous. But what if you have low blood glucose levels or hypoglycemia? Whether you have diabetes or not low blood sugar levels can be ...
By Genteel LLC
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