Parkinson`s disease Articles
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Levodopa delivery systems for the treatment of Parkinson`s disease: an overview
Abstract This review describes the different drug delivery systems containing levodopa that are used in the treatment of Parkinson's disease. Their composition, process of preparation, advantages, disadvantages and limitations are discussed as well as the major objective in the management of Parkinson's disease according to the pathology of the disease. ...
By Sensidose AB
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The Structure of Key Proteins in Parkinson`s Disease Solved
Australian researchers have recently solved a multi-year mystery about Parkinson's disease. They solved the structure of a key protein that is expected to rapidly treat this incurable disease. The findings appear in Nature. For the first time, the researchers took a "live" shot of a protein called PINK1. The findings explain how this protein is activated in cells, thereby initiating the ...
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Levodopa therapeutics for Parkinson`s disease: new developments
Abstract Levodopa serves as the gold standard of anti-parkinsonian therapy and nearly every patient with Parkinson's disease eventually receives this drug. To improve upon levodopa therapy, several forms of treatment have been devised to augment its actions, and new delivery systems are under development. This new research offers promise for improving outcomes with this highly effective ...
By Sensidose AB
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New levodopa therapeutic strategies
Abstract During its almost half-century of use for treating Parkinson's disease, levodopa therapy has permitted most patients to reverse much of this disorder's symptomatology. However, the full range of its therapeutic properties is not completely understood, as levodopa is showing itself to be more than just a metabolic intermediate for dopamine synthesis. Improving the constancy of drug ...
By Sensidose AB
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Development of new levodopa treatment strategies in Parkinson`s disease-from bedside to bench to bedside
Abstract This review will illustrate the process of moving from an idea through preclinical research and Galenic developments into clinical investigations and finally to approval by regulatory agencies within the European Union. The two new treatment strategies described, levodopa/carbidopa intestinal gel and levodopa/carbidopa microtablets, for advanced Parkinson's disease, have been ...
By Sensidose AB
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Relevance of motor complications in Parkinson`s disease
Abstract Although patients with Parkinson's disease usually respond to dopaminergic therapy with a smooth, continued effect when medication is first initiated, many patients eventually develop a fluctuating response along with involuntary movements (dyskinesias). The fluctuations in motor response often result in patients requiring more frequent dosing of medication that is less convenient, ...
By Sensidose AB
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An automatic dose dispenser for microtablets--a new concept for individual dosage of drugs in tablet form
Abstract A new concept for individualising the dosage of drugs in solid form is presented. The principle is based on the use of standardised units (microtablets), each containing a subtherapeutic amount of the active ingredient. The required dose is fine-tuned by counting out a specific number of these units. The microtablets are counted electronically from the attached cassette by the ...
By Sensidose AB
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Parkinson`s disease therapy: tailoring choices for early and late disease, young and old patients
Abstract Advances in the understanding of basal ganglia circuitry and its altered function in disease states such as Parkinson's disease (PD), coupled with new insights into the mechanisms of cell death and new findings from therapeutic clinical trials, are being translated into clinical practice. Although levodopa (L-Dopa) remains the most effective drug in the symptomatic treatment of PD, ...
By Sensidose AB
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Signs of Parkinson’s Disease to Watch For
Parkinson’s disease is a progressive neurodegenerative disease that is most commonly known for affecting movement. It primarily impacts dopaminergic, or dopamine-producing, neurons in a specific area of the brain known as the substantia nigra. Typically, symptoms develop slowly over years and continue to worsen as the disease progresses. While the manifestation of symptoms tends to vary ...
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Drug adherence in Parkinson`s disease
Abstract Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor ...
By Sensidose AB
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Alzheimer’s and Parkinson’s Disease: A Breakdown of the Differences and Similarities
Alzheimer’s and Parkinson’s disease are both neurological diseases that cause progressive damage to the brain, resulting in a decline in neurocognitive function. While Parkinson’s disease is known for affecting movement and function and Alzheimer’s disease is known for affecting cognition, they are a bit more complex than that. Below, we provide an overview of ...
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Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice
Deep brain stimulation (DBS) is used to treat multiple neuropsychiatric disorders, including Parkinson’s disease (PD). Despite widespread clinical use, its therapeutic mechanisms are unknown. Here, we developed a mouse model of subthalamic nucleus (STN) DBS for PD, to permit investigation using cell type–specific tools available in mice. We found that electrical STN DBS relieved ...
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Genetic Link to Parkinson`s Disease Is Best Hope for the Future in Rare Disease
Collaboration Announced Between Researchers at University of California Irvine and Population Diagnostics, Inc. at Rare Disease Event in Southern California The Spooner Girls Foundation , University of California, Irvine School of Medicine, (UCI) and Population Diagnostics, Inc. (PDx), announced today a collaborative research initiative focused on the NUBPL gene at the Spooner family’s ...
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How Is Frontotemporal Dementia Different From Alzheimer`s?
People living with frontotemporal dementia, or FTD, are commonly misdiagnosed with psychiatric disorders or Alzheimer’s disease and other causes of dementia, such as Parkinson’s disease and vascular dementia. While frontotemporal dementia and Alzheimer’s disease can both cause dementia, there are distinct differences in impacted regions of the brain and, consequently, ...
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Why participants are so important to health research
Health research is very important for improving health care for all. As we mentioned in a previous article, What is Health Research?, this type of research helps medical researchers understand people’s health and how we can make treatments better for everyone. But health research isn’t possible without the contributions of research participants. Research participants are ...
By Evidation
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One leg test balance! Very challenging
Standing on one leg is an essential task in activities of daily living (ADLs), from walking to stair climbing, shower transfer and lower body dressing (while standing). Besides that, it is necessary in many occupational and sports activities, making it an important stance to be included within a balance assessment session. One-leg stance duration is one the oldest balance tests using a simple ...
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What is a Posturography?
What is it? Posturography is a non-evasive technique that quantifies an individual’s balance behavior in upright stance. As mentioned in previous articles (What is Balance?), balance is achieved and maintained by a complex set of sensorimotor control systems, which includes the visual, somatosensory and vestibular systems. It is through their integration in real time by the central ...
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Oliver Sacks: the patient-focused polymath
A man sits on a stage and begins to speak. He is humble and soft spoken; he talks tenderly about a patient of his – an elderly lady in a home who had started to hallucinate. He recalls the story of how he diagnosed her, smiling as he retells the lady’s jokes and remembers how happy she was to understand what was happening to her. The man is Dr. Oliver Sacks, a world-renowned ...
By Elsevier B.V
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Limits of Stability - The most used protocol for balance assessment
The Limits of Stability (LOS) is perhaps the most used protocol in the literature for balance assessment in a dynamic task. It quantifies the ability to intentionally displace the center of gravity to the patient’s stability limits without losing balance. This protocol provides information regarding voluntary motor control, which also helps screening fall risk in elderly people [1]. How ...
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The Role of Chx10 Neurons in Global Motor Arrest
A recent study by Goni-Erro et al (2023) in Nature Neuroscience has shed light on a fascinating phenomenon: the neural control of global motor arrest. From the cessation of goal-directed actions to a broader motor arrest in response to fear or environmental cues, this complex behavior involves an intricate set of neuronal pathways. This recent study reveals that the activation of ...
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