Pathology Physiology Articles & Analysis
12 articles found
Immortalized human podocytes represent a significant advancement in the field of renal research, offering scientists an unprecedented opportunity to study kidney function and pathology. These specialized cells play a crucial role in the filtration barrier of the kidneys, and their immortality allows for extended experimentation beyond the limitations of primary cell cultures. ...
The Role of Podocytes in Kidney Disease Recent research has highlighted the importance of podocytes in various renal pathologies. Conditions such as diabetic nephropathy, focal segmental glomerulosclerosis, and nephrotic syndrome are characterized by podocyte injury or loss. ...
These models can recapitulate aspects of human physiology, pathology, and behavior, making them indispensable in translational research. ...
Due to their crucial roles in physiological and pathological processes, nuclear receptors have emerged as significant targets for drug discovery and development. ...
Therefore, the detection of sialic acid proteins holds significant value in disease diagnosis, biomedical research and drug development.Biological Importance of Sialic Acid ProteinsSialic acid proteins play an indispensable role in many physiological and pathological processes. Under normal conditions, they participate in intercellular communication, regulation ...
By studying the protein interaction network, it reveals the molecular mechanisms of various physiological and pathological processes in cells, providing new ideas for disease diagnosis and treatment. ...
Ubiquitination detection contributes to a better understanding of the role of ubiquitination in cellular physiological and pathological processes, particularly in studying protein degradation, signal transduction disorders, and molecular mechanisms associated with various diseases such as cancer and neurodegenerative diseases. ...
Introduction Cellular mechanisms driving cell death play a crucial role in various physiological and pathological processes. One such mechanism is apoptosis, a tightly regulated process vital for maintaining tissue homeostasis, development, and immune response. ...
It contributes extensively to the understanding of the physiological function of ionic channels in health and disease. From exploring their roles in some neurological disorders, cardiovascular diseases to electrolyte imbalance—it's a resourceful tool. ...
Professor Cravatt, a professor in the Department of Chemistry at the Scripps Research Institute, focuses on understanding protein function in human physiological and pathological processes and using the resulting knowledge to discover innovative therapeutic targets, as well as new drugs for the treatment of diseases. ...
Results: The inherent reproducibility of the WPS measurement technique itself and from the underlying gut activity, coupled with source validation and sensitivity to changes in gut activity in several physiologic and pathologic states, demonstrates its feasibility, safety, and performance in clinical settings. ...
RTEs have been linked to stem cell function, tissue differentiation, cancer progression and ultimately to aging and age-related pathologies. The study by Wang et al. recently published inPNAS(July 27, 2015) provides a new perspective on the role that RTE-derived sequences play in the precise execution of the human genome's regulatory program. ...