patient dose Articles
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Assessment of patient doses in X-ray diagnostics
This paper presents a computer code for the assessment of absorbed effective doses and dose equivalents in X-ray diagnostics. The absorbed doses in a patient's tissues in various X-ray examinations were estimated using the Monte Carlo method. The X-ray spectra generated by the empirical TASMIP model were verified. Further simulations were based on an anthropomorphic phantom of a standard adult. ...
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INOVA Schar Cancer Institute - External Beam Electron Treatment of SCC - Case Study
This case report provides an excellent example of how Adaptiiv’s software can be effectively used to generate a customized bolus for an irregular surface region with consistent patient setup reproducibility, improved dose conformity and accurate dose ...
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Relevance of motor complications in Parkinson`s disease
Abstract Although patients with Parkinson's disease usually respond to dopaminergic therapy with a smooth, continued effect when medication is first initiated, many patients eventually develop a fluctuating response along with involuntary movements (dyskinesias). The fluctuations in motor response often result in patients requiring more frequent dosing of medication that is less convenient, ...
By Sensidose AB
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Aramis Biosciences Announces First Patient Dosed in Phase 2 Clinical Trial Evaluating A197 for the Treatment of Dry Eye Disease
Aramis Biosciences announced that the first patient has been dosed in its phase 2 proof of concept clinical trial evaluating A197, a novel, first-in-class, topical immunomodulatory agent for the treatment of dry eye disease. “This is an important milestone for Aramis Biosciences and a hopeful moment for dry eye patients given the suboptimal efficacy and tolerability limitations commonly ...
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Do You Have Processes in Place to Comply with USP <797>?
Hospital central fill facilities and individual hospitals will soon need to comply with the updated USP guidelines. While the regulation is not yet in place, it’s important to have a plan in place for your organization. In the event of an accreditation survey or audit, would you be in compliance with the updates today? Master Formulation Record As part of the updated USP General ...
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Persistent gene editing therapy using LNP-delivered mRNAs
Gene editing technology, represented by CRISPR/Cas9, has greatly accelerated the development of gene therapy, bringing hope to many genetic diseases that otherwise had no cure. In June 2021, Intellia Therapeutics' NTLA-2001, a CRISPR gene editing therapy for the treatment of transthyretin amyloidosis (ATTR) invented by Nobel Laureate Jennifer Doudna, was proven to be safe and effective in a ...
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Driving Data-driven Medicine to Advance Personalized Care
Clinical trials are often designed with the participant’s everyday life in mind – trying to gather as much clinically-relevant data in a controlled manner as possible while allowing individuals to live their regular lives. However, it is true that trials are artificial environments, and participants are actively monitored to ensure their safety and to determine the efficacy of a drug ...
By AiCure
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Bridging Clinical Research to Real-World Patient Care Through Predictive Analytics
The ability to predict how a clinical trial participant will adhere to their treatment, and even respond to that treatment, has great promise to advance patient-centric clinical research. But, as we look to understand the impact a drug has on patients’ everyday health outside of a research environment, what happens to these unique, predictive findings around dosing and outcomes once a drug ...
By AiCure
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Huateng Pharma Develops Intermediates of Carfilzomib For Multiple Myeloma
Carfilzomib, a proteasome inhibitor, is indicated for the treatment of patients with multiple myeloma. Multiple myeloma (multiple myeloma, MM) is a malignant tumor originating from the B cell lineage, characterized by the clonal proliferation of malignant plasma cells in the bone marrow microenvironment, causing fractures and bone marrow failure, and is the second most common blood system ...
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More Careful Scrutiny Encouraged for Purification and Quantitative Testing of Nutritional Supplements
Recent case of selenium toxicity points to need for FDA to toughen regulations for supplements. MacFarguhar et al have written an excellent article in the Feb. 8, 2010 edition of the Archives of Internal Medicine entitled “Acute Selenium Toxicity Associated with a Dietary Supplement.” They report that in 2008 a chiropractor in Florida noted common symptoms of gastrointestinal illness ...
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Effect of combined Low-Dose Radon- and Hyperthermia Treatment (LDRnHT) of patients with ankylosing spondylitis on serum levels of cytokines and bone metabolism markers: a pilot study
Ankylosing Spondylitis (AS) is a rheumatic disease and almost 50% of the affected patients suffer from osteoporosis. The ratio of Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Osteoprotegerin (OPG) has become an important marker to assess the status of systemic bone metabolism and has been shown to be dysregulated in AS patients. Combined Low-Dose Radon- and Hyperthermia Therapy ...
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Radiation-induced DNA damage in patients exposed to X-rays during cerebral angiography
Population exposure to diagnostic and therapeutic ionising radiation is likely to increase worldwide, and this has raised concerns about the stochastic effects of low doses of radiation exposure. The present study was aimed to study the incidence of Chromosomal Aberrations (CAs) in patients exposed to low doses of X-rays during diagnostic interventional radiological procedures. Peripheral blood ...
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What makes Biodegradable Microspheres ideal for Controlled-release Drug Delivery?
Patient-centric drug development is a divisive concept. Dismissed as a buzzword by some. Adopted extensively by others. It has, nevertheless, gained enormous traction over the last decade. This new approach to treatment incorporates patient perspectives into drug development. A key benefit is the keener focus on convenience and safe drug administration. Traditional approaches, prioritising ...
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Rani Therapeutics prices $73M IPO for robotic drug-delivery pill tech
Rani Therapeutics Holdings (NSDQ:RANI), developer of a robotic drug-delivery pill system, generated $73.3 million in its underwritten initial public offering (IPO) of Class A common stock. The San Jose, Calif.–based company’s IPO of 6.7 million shares priced at $11 a share, generating gross proceeds of $73.3 million. The company initially targeted an IPO worth approximately $100 ...
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Development of an in vivo assay for detection of non-targeted radiation effects
An adaptive response may be defined as the effect of a small priming dose of radiation modifying the anticipated cellular response of the same tissues so as to alter the predicted response to a larger dose of radiation. We and many others have demonstrated that at low radiation doses (less than 0.5 Gy) the lethal and mutational effect of the radiation is mainly, possibly entirely, due to the ...
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From Predicting Adherence to Health Outcomes – The Power of Predictive Insights
Clinical researchers have begun adopting predictive analytics to anticipate a patient’s engagement in a clinical trial, including if and how a patient will adhere to their treatment plan. As these models are fed more patient-level audio and visual data, they have the potential to open up a whole new world of a patient’s lived experience – from how a patient will respond to their ...
By AiCure
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Lucas Heights Reactor Shutdown Highlights Need for US Nuclear Corp. Technology
DENVER, CO / ACCESSWIRE / July 16, 2018 / On June 22nd a mechanical failure at the Lucas Heights nuclear reactor in Sydney, Australia shined a light on the tenuous supply chain of medical radioisotopes worldwide. These isotopes are key tools in both diagnosis and treatment for a wide range of medical conditions. The mechanical error at the Sydney plant sent hospitals throughout Australia and ...
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Rani is Opening Doors in Biosimilars, Challenging Humira and Others
San Jose-based Rani Therapeutics reported its fourth quarter and full-year 2021 financial results, as well as several corporate updates. The company hit major milestones this year, including the recent launch of the RaniPill High Capacity, which opens doors for significant developments in biosimilars. Rani has been on the radar of major life science investors for years. The company caught ...
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A Rationally Designed Therapeutic Vaccine for Herpes
Founder and CEO, Agustin Fernand of Rational Vaccines that is developing a vaccine for herpes. There is a pandemic raging across the world – and it has nothing to do with a coronavirus. Approximately 500 million people worldwide suffer from genital herpes. Several billion more have an oral herpes infection. Herpes is a life-altering disease that can lead to chronic pain, blindness, and ...
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Drug Delivery: What do Patients and Providers Want?
Citation: Huddleston M, Estep J, “Drug Delivery: What do Patients and Providers Want?” ONdrugDelivery, Issue 124 (Sep 2021), pp 10–14. Matthew Huddleston and Jennifer Estep discuss current drug delivery options and the value of convenient care. Worldwide, patient and provider preferences are changing due to the covid-19 pandemic. The need to reduce patient exposure to the ...
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