pharmaceutical drug Articles
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India's new patent regime: aiding 'access' or abetting 'genericide'?
This paper considers the impact of the new Indian patent regime on the important issue of access to affordable drugs. Access is dependent, in part, on the ability of generic manufacturers to produce cheap generic drugs. Working with the bird flu patent example, this paper will demonstrate that far from abetting 'genericide', the new regime provides adequate legal windows to aid the continued ...
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Biotechnology clusters, "Big Pharma" and the knowledge-driven economy
The pharmaceutical industry remains powerful due to its firm scale and global reach. However, analysis of the source of biotechnology-derived products in healthcare, valued at $70 billion worldwide by 2000, reveals an almost complete dependence, in three key markets of the USA, UK and Germany, on products developed by entrepreneurial biotechnology firms. These tend to operate in knowledge-driven ...
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Global pharmaceutical industry: intellectual wealth and asset protection
This is a commentary on the recent trends in the protection of intellectual assets in the Global Pharmaceutical Industry. Patenting inventions, enforcing acquired rights, evolving newer ways of sharing knowledge for effective cooperative working through diverse licensing arrangements between organisations are the keys to success in this fiercely competitive industry.Keywords: intellectual assets, ...
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Nanobiotechnology approaches for targeted delivery of pharmaceutics and cosmetics ingredients
Nanobiotechnology refers to the ability to create and manipulate biological and bio-chemical materials, devices, and systems at atomic and molecular levels. Nano delivery systems hold great potential to overcome some of the obstacles in bio-pharmaceutical production, such as water soluble/insoluble pharmaceutical drugs and cosmetic ingredients, risks of toxicity, increasing bio-active efficacy, ...
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How to Achieve Quality by Design (Qbd) in a New Pharmaceutical Fill Line: Cleaning and Disinfection (Series Part 3 of 6)
The cleaning and disinfection of a pharmaceutical fill line & surrounding areas is a critical component of contamination control. We all think we are familiar with the principles of cleaning protocols, but it is deceptively easy to get this form of control wrong without applying the standards of QbD to the new equipment and facility at the design phase. There are many things to consider from ...
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Adaptive Designs in nQuery - Case Study
Effective and Efficient Drug Development Challenge Increased Cost, Risk, and Competition in the Drug Development Processes Dr. Luis Rojas, the Executive Director Head of Biostatistics at Target Health, is a subject matter expert in study design and sample size calculations with more than 30 years of industry experience. He has worked in the leading CROs in the industry and has assisted ...
By Statsol
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Commercialisation of bio-pharmaceutical therapies and risk management: the impact on the sustainability of markets for recombinant drugs
Due to its influence on changes of research paradigms and development of hitherto unknown applications, commercialisation of biotechnological knowledge causes new challenges for regulatory procedures in pharmaceutical markets. By affecting time and probability of successful commercialisation, private and public institutions systems of risk management also influence the structure of financing ...
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Exposure and food web transfer of pharmaceuticals in ospreys (Pandion haliaetus): Predctive model and empirical data
The osprey (Pandion haliaetus) is a well‐known sentinel of environmental contamination, yet no studies have traced pharmaceuticals through the water‐fish‐osprey food web. A screening‐level exposure assessment was used to evaluate the bioaccumulation potential of 113 pharmaceuticals and metabolites, and an artificial sweetener in this food web. Hypothetical concentrations in water reflecting ...
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Choosing a CDMO: 7 Key Factors to Keep in Mind
The pharmaceutical industry is a highly dynamic industry. It is constantly innovating new and complex drugs with great efficacy. This poses a challenge for generic companies to keep up and develop drugs that match the same level of complexity and effectiveness within a reasonable timeframe and budget. To address this challenge, generic companies often outsource their drug ...
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Towards a fourth generation R&D management model-research networks in knowledge management
Research and development (R&D) management is increasingly about managing knowledge rather than simply managing its generation. Better management of knowledge is a key success factor for industry competitiveness through continuous innovation. R&D management processes developed in the past, which can be described as the first, second, or third generation models, deal with concepts, techniques and ...
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Spray Drying of polymeric micelles - Case Study
Customer: Technion-Israel Institute of Technology, Haifa, Israel The research focuses on the pharmaceutical nanomaterials science and drug delivery fields, with special interest in biomaterials science, colloidal chemistry (drug and polymer self-assembly), mucoadhesive drug delivery systems, nanomedicine (drug encapsulation, release and targeting). Application: Drying polymeric micelles ...
By BUCHI
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World Health Organization Guidance on the Storage and Transport of Temperature Sensitive Pharmaceutical Products
Background The World Health Organization (WHO) publish guidelines for the storage and transport of temperature sensitive pharmaceutical products. Many pharmaceuticals, drugs and vaccines have time and/or temperature dependent requirements. The WHO guidelines are based upon existing worldwide regulations and best practices. Local regulations, policies and directives will take precedence over the ...
By AKCP
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Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in saccharomyces cerevisiae
The study of eukaryotic membrane proteins has been hampered by a paucity of systems that achieve consistent high-level functional protein expression. We report the use of a modified membrane protein hyperexpression system to characterize three classes of fungal membrane proteins (ABC transporters Pdr5p, CaCdr1p, CaCdr2p, CgCdr1p, CgPdh1p, CkAbc1p, and CneMdr1p, the major facilitator superfamily ...
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Nanopharmaceuticals I: nanocarrier systems in drug delivery
To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have ...
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Stability Analysis: A Meaningful, Impactful and At-the-Forefront Tool for Pharmaceutical Science
In the field of pharmaceutical science, stability analysis plays a crucial role in ensuring the safety and efficacy of pharmaceutical products. It is a complex and multifaceted process that requires thorough investigation and understanding of various influencing factors. Stability analysis consists of different methods such as influencing factors analysis, long-term accelerated shelf-life ...
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The Effects of Excipients on Pharmaceutical Preparation
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
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The Effects of Excipients on Pharmaceutical Preparations in Drug Design
Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more ...
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Elimination of active pharmaceutical ingredients (APIs) and other problematic components from wastewater
Pharmaceuticals and their metabolites are detected on an increasing scale in the aquatic environment. The pharmaceuticals (such as drugs) mostly get into the surface and drinking water through the excretions of humans and animals; however, the wastewater of pharmaceutical production facilities can also be contaminated with active ingredients. The production of pharmaceuticals takes place in two ...
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Spray Drying of polymeric micelles - Case Study
“The Nano Spray Dryer B-90 HP shows high potential to investigate innovative nanoparticle types for nanopharmaceuticals and drug delivery, including stabilization of self-assembly nanomaterials such as polymeric micelles.” Customer name Prof. A. Sosnik, Head Laboratory of Pharmaceutical Nanomaterials Science Company / Institution Technion-Israel Institute of Technology, Haifa, ...
By BUCHI
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How to Select Pharmaceutical Excipients?
Pharmaceutical excipients refer to the substances used in the production and formulation of medicines. They perform multiple functions in pharmaceutical preparations and are likely to affect the quality, safety and effectiveness of drugs. Pharmaceutical excipients can be classified into natural, semi-synthetic and fully synthetic compounds according to their sources. And based on their use, ...
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