physiological functioning Articles
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Nutrigenomics
Nutrigenomics deals with studying of molecular relationships between nutrition and the response of genes. Also involves the characterisation of gene products and the physiological function and interactions of these products. Nutrigenomics focuses on the effect of nutrients on the genome, proteome, metabolome and explains the relationship between these specific nutrients and nutrient-regimes on ...
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Function of heterologous mycobacterium tuberculosis inha, a type 2 fatty acid synthase enzyme involved in extending c20 fatty acids to c60-to-c90 mycolic acids, during de novo lipoic acid synthesis in saccharomyces cerevisiae
We describe the physiological function of heterologously expressed Mycobacterium tuberculosis InhA during de novo lipoic acid synthesis in yeast (Saccharomyces cerevisiae) mitochondria. InhA, representing 2-trans-enoyl-acyl carrier protein reductase and the target for the front-line antituberculous drug isoniazid, is involved in the activity of dissociative type 2 fatty acid synthase (FASII) that ...
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Polo-like kinase 1 is essential for early embryonic development and tumor suppression
Polo-like kinases (Plks) are serine/threonine kinases that are highly conserved in organisms from yeasts to humans. Previous reports have shown that Plk1 is critical for all stages of mitosis and may play a role in DNA replication during S phase. While much work has focused on Plk1, little is known about the physiological function of Plk1 in vivo. To address this question, we generated Plk1 ...
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Everything You Want to Know About Lipoprotein Lipase
Lipoprotein lipase (LPL) is a glycoprotein synthesized and secreted by parenchymal cells such as adipocytes, cardiomyocytes, skeletal muscle cells, mammary cells, and macrophages, with a molecular weight of 60ku and containing 3-8% carbohydrates. The physiological function of LPL is to catalyze the breakdown of TG in the core of CM and VLDL into fatty acids and monoglycerides for tissue oxidative ...
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The Science Behind Dietary Supplements: Exploring Efficacy and Safety of Popular Ingredients
Dietary supplements have become increasingly popular in recent years as individuals seek to optimize their health and well-being. When it comes to popular dietary supplement ingredients, several categories stand out, including vitamins, minerals, amino acids, enzymes, botanicals, and more. Each of these components plays a crucial role in supporting various physiological functions in the human ...
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Discovery of Pathways that Promote Remyelination
In the evolutionary history of vertebrates, the emergence of myelin has made the transmission of neural signals much faster, and if humans evolve like invertebrate squid, the vertebral diameter of humans may be thicker than that of giant red fir trees. Insulating myelin sheaths encapsulate nerve axons, thereby allowing rapid conduction of action potentials between neurons, and in addition, myelin ...
By Profacgen
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The Small RNA Sequencing Service Is Now Available Through RNA Solutions Platform
RNA Solutions is a platform that offers services for the revolutionizing study of RNA, targeting both coding and non-coding RNAs of different physiological functions. The scientists at CD Genomics are ready to help detect various types of RNA via meticulous and integrative approaches. Recently, the company announced Small RNA Sequencing, which helps researchers quickly identify known and unknown ...
By CD Genomics
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Could more sunshine make you less anxious?
It is no surprise that basking in sunshine can do a lot to improve your mood, but do you know about the link between vitamin D and mental health? Sunlight is the best source of vitamin D, which we need to enable our bodies to convert the calcium in our diets to strengthen our bones. In addition to maintaining good bone health, vitamin D has been linked with many other physiological functions in ...
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What Is a Good Heart Rate Variability? : Modern Health and Fitness
Defining a good heart rate variability has always been a question within the fitness community. Different lifestyles can dictate a person’s overall cardiovascular health which is why the answer typically varies from person to person. Thankfully, with modern advancements in technology, it’s now much easier to track and monitor these types of health information. We can now check not ...
By Sky Labs
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Structural Characteristics and Functions of Glycoproteins, Proteoglycans and Glycolipids
Sugar is an important nutrient for the human body, and its primary physiological function is to provide energy and carbon sources for life activities. In addition, sugar also participates in the composition of glycoproteins and glycolipids, and regulates cell information transmission. Monosaccharides are polymerized by glycosidic bonds to form oligosaccharides or polysaccharides, also called ...
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Food Nutrition Enhancers
Food nutrition enhancer, also called food nutritional fortifier, refers to natural or synthetic nutrients added to food in order to increase its nutritional content. It can not only supplements people's daily nutritional intake, but also has a positive effect on disease prevention and control. The food nutrition enhancers can be divided into four main categories as following. Vitamins Vitamins ...
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The Mode of Action of Basic Proteins Involved in Cancer and Alzheimer's Disease Found
These proteins belonging to the HAT family are essential for life because they transport amino acids to the cell membrane. Although members of the family are nearly identical, they selectively transport certain amino acids. This specificity determines their involvement in specific functions, such as cell growth or neuronal function, and consequently in related diseases, such as cancer or ...
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The Sophisticated Mechanism of Epigenetic Induction Facilitating Cellular Proliferation Service
The intricate nature of cellular growth and proliferation has been a fascinating subject of study for cell biologists for many decades. Recently, with the advent of cutting-edge gene manipulation and control techniques, increasing emphasis has been laid on comprehending the role of epigenetic induction in facilitating cell growth. This article focuses on shedding light on the ingenious process of ...
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How Much Do You Know about Targeted Protein Degradation Drugs?
Targeted protein degradation (TPD) technology is a new technology that specifically recognizes the target protein and directly degrades the target protein using the inherent protein degradation pathway in the cell. At present, technologies such as PROTACs, molecular glues, degradation tags, lysosome-targeted chimeras, and autophagosome-binding compounds have been developed in the field of TPD, ...
By Profacgen
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Predicting cardiotoxicity with engineered 3D human cardiac tissue models
Cardiovascular safety liabilities caused 52.3 % of 44 marketed data from 1980 to 2011, and cardiovascular disease remains the leading cause of death globally, yet only 8.7% of cardiovascular drugs successfully pass clinical trials. These statistics demonstrate the need to address a patient’s specific genetic make-up and phenotype by adopting a personalized treatment methodology for ...
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Mitochondrial Proteins
Mitochondria are dynamic organelles with bilayer membranes. Mitochondria have multiple functions, not only providing energy to cells through oxidative phosphorylation to produce ATP, but also involved in regulating processes such as calcium homeostasis, reactive oxygen species (ROS) production, cellular stress response and cell death. Mitochondria play a key role in maintaining cellular health ...
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Protein degradation therapy development: SWOT
The Dana-Farber Cancer Institute utilized SWOT analysis to targeted protein degradation drug development to better evaluate the approach's strengths, weaknesses, opportunities, and threats. SWOT (Strengths-Weaknesses-Opportunities-Threats) analysis is frequently used in business development and strategic planning, but it may also be used to critically analyze quickly evolving fields, as the ...
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Mitochondrial Proteomics
Mitochondria are important organelles of eukaryotic cells and play a key role in the regulation of cellular energy metabolism, biosynthesis and cell death (including apoptosis and programmed cell necrosis). In addition, mitochondria are involved in important physiological processes such as tricarboxylic acid cycle, fatty acid and amino acid oxidation, and regulation of calcium ion homeostasis. ...
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Unlocking the Possibilities of Customized Ionic Channel Expression Systems
Ionic channels, which are proteins present in the membranes of all living cells, are gaining significant importance in the fields of bio-medicine and biotechnology. They are responsible for the transmission of signals across cell membranes and are instrumental in multiple biological processes. This raises the demand for a systematic mechanism that can control their expression. The customized ...
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Foundational Supplement Program with Whole Food AstaPure® Arava
One of the most pressing questions consumers have is, "What supplements do I need to take daily?" The answer should be simple, start with a strong foundation. Just as if you were building a home, you would first pour a strong foundation in which to build on. The same holds with taking dietary supplements. The four areas of supplementation consumers need fall into these categories: Antioxidant(s), ...
By Algatech
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