polymer biomaterial Articles
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Molecular interactions of degradable and non-degradable polymers with hydroxyapatite influence mechanics of polymer-hydroxyapatite nanocomposite biomaterials
Implant materials composed of hard and soft phases (composite materials) have shown much promise for total bone replacement. Interfacial interactions between the components in these composite biomaterials affect the overall mechanical response. Here, the role of interfacial interactions on the load deformation behaviour of soft phase (polymer) have been analysed using constant velocity Steered ...
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Polypyrrole incorporating biomolecules
Polypyrrole (PPy) is a conducting polymer with emerging applications in biomedical engineering. We report on the synthesis and properties of PPy incorporating biomolecules using AC impedance spectroscopy. Impedance behaviour was consistent with two basic charge transfer processes, polaronic and electronic, demonstrated by two-electrode impedance spectroscopy over the frequency range 5 Hz?13 MHz. ...
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New Method to Produce Ring-Opening Metathesis Polymers with Facile Degradability
A team of chemists at MIT has formulated a method to produce polymers that can disintegrate more readily in the body as well as in the environment. A new type of polymer designed by MIT chemists incorporates a special monomer (yellow) that helps the polymers to break down more easily under certain conditions. (Image credit: Demin Liu) A chemical reaction known as ring-opening metathesis ...
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What Are Heparins?
Heparin, also known as standard heparin or unfractionated heparin, is a linear polysaccharide consisting of 1-4 linked disaccharide repeat units of uronic acid and glucosamine residues. Heparin was discovered nearly 100 years ago and has been used clinically as a blood anticoagulant since 1935. This is due to its ability to bind to the antithrombin(serine protease inhibitor), causing the ...
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Bioactive compounds obtained by immobilisation of serine protease inhibitors
We studied the preparation of polymeric membranes formed of solutions of poly–3–hydroxybutyrate (PHB) and chitosan. PHB–chitosan biomaterials from these solutions may form various structural types, which determine the biodegradation time, the adsorption capacity, and the kinetics of the release of medicinal compounds from polymeric matrices. Serine protease inhibitors, SERPINs, continue to catch ...
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Tepha - case study
Tepha Inc. is a medical device firm that develops and commercializes innovative products based on the company’s proprietary PHA (polyhydroxyalkanoate) bioaterial technology. Tepha began working with POS in 2002 to develop its biopolymer resin production processes. These novel process had not yet been demonstrated at the pilot plant scale when the company started working with POS. Today, ...
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