Preclinical Models Articles & Analysis: Older
30 articles found
Furthermore, while liposomes have shown promise in preclinical models, translation to the clinical setting has been met with variable success. Factors such as complex in vivo dynamics and interpatient variability can affect liposome pharmacokinetics and biodistribution, underscoring the need for more predictive preclinical models ...
Alfa Cytology’s team of scientists can design more effective vaccine programs, and conduct preclinical evaluations on the safety and efficiency of vaccines. Moreover, to further explore the mechanism of PC occurrence, development, invasion, and metastasis, Alfa Cytology independently developed PC model construction services, dedicated to offering different ...
This blog delves into a fascinating study that investigates how altered ventilatory responses to hypercapnia-hypoxia (HH) challenges in a preclinical SUDEP model implicate orexin ...
Quality Control of Aluminum-adjuvanted Vaccines First, the nature of the surface charge of aluminum-adsorbed antigens needs to be understood in order to predict the physical properties of vaccine suspensions; Second, determining the rate and strength of adsorption of aluminum adsorbed antigens can help us to understand the ability of aluminum adjuvants to adsorb antigens, as well as their ...
Due to their low prevalence and limited understanding, treating and finding cures for these conditions present significant challenges. However, preclinical animal models have emerged as invaluable resources for advancing research and unraveling the mysteries surrounding rare diseases. ...
It is worth noting that the REGN5093-M114 naked antibody itself also has a certain effect in inhibiting tumors and has demonstrated good efficacy in various preclinical models. M1231 The targets of most bispecific ADCs are two different epitopes of the same target, such as the three products above. ...
Numerous studies employing syngeneic and spontaneous tumor models have demonstrated that genetic deletion or pharmacological inhibition of CD73 or A2AR significantly reduces tumor growth and metastasis. ...
However, these are currently in preclinical research, and it will take time to verify how far they will go in the future. ...
Another advantage of scRNA-seq in drug development is the selection of relevant preclinical disease models. Traditional disease models often fail to recapitulate the cellular heterogeneity observed in human tissues, limiting their predictive value for drug responses. ...
Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. One critical component of this evaluation is the use of preclinical animal models. Preclinical animal models serve as ...
Relevance of scRNA-seq in Drug Development In drug development, scRNA-seq plays a crucial role in selecting relevant preclinical disease models. Traditional models often fail to capture the cellular heterogeneity observed in human tissues, limiting their predictive value for drug responses. Profiling patient samples using scRNA-seq helps identify ...
Understanding the functional characteristics and cellular tropism of SARS-CoV-2, as well as the pathogenesis leading to multi-organ failure and death, has driven the unprecedented adoption of organoid models. Successful drug discovery and vaccine development rely on preclinical models that faithfully recapitulate the viral life cycle and host ...
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
These devices, deployed in the suprarenal descending thoracic aorta, displace blood and create a negative pressure head above the pump and reduce left ventricular afterload, thereby potentially increasing cardiac output. Preclinical testing showed that in contrast to thoracic positioning, abdominal positioning of the newest generation Aortix device reduces left ventricular ...
"Targeting CSF1 may therefore be a good strategy for the treatment of AUD, and we are now eager to test this in our preclinical models," Patel ...
” This translational study analyzed patient tissues, preclinical models and retrospective data to determine how the IL-6 T helper 17-cell (Th17) pathway is involved in toxic responses and can be inhibited to separate inflammatory autoimmune responses and antitumor immunity reaction. IL-6 has been implicated in resistance to immunotherapy in ...
December 28, 2021 - Rational Vaccines announced preclinical research suggesting that the Company's herpes simplex virus type 1 (HSV-1) vaccine candidate (RVX1001) can protect against herpetic keratitis, a leading infectious cause of blindness in developed countries. ...
Here we directly compared the susceptibility of ePTFE grafts and HAV to bacterial contamination in a preclinical model of infection Materials and methods: Sections (1 cm2 ) of ePTFE (n ¼ 42) or HAV (n ¼ 42) were inserted within bilateral subcutaneous pockets on the dorsum of rats and inoculated with Staphylococcus aureus (107 CFU/0.25 mL) or ...
Rare Cancer Mutation Research Using Genetic Panel TestingRare cancers (RCs) research often lacks preclinical models for evaluation and studying pathogenesis, making it difficult to find effective treatments. ...
He and his team studied pancreatic cancer metabolism in preclinical models: how cells acquire nutrients and what nutrients they use to promote growth and achieve therapeutic resistance. ...