Preclinical Models Articles & Analysis: This-Year
8 articles found
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
For example, research from the MD Anderson Cancer Center has shown that dual inhibition of both BCL2 and MCL1 can be effective in preclinical models of multiple myeloma. By targeting both of these anti-apoptotic proteins, the combination therapy can overcome resistance mechanisms that limit the effectiveness of single-agent therapies. ...
For instance, CXCL10 has shown promise in preclinical models by enhancing T-cell infiltration into tumors. Additionally, chemokines play a role in vaccine development. By co-administering chemokines like CCL19 or CCL21, researchers have improved antigen presentation and immune memory in several vaccine models. Emerging Research and Challenges ...
Pre-Clinical Analysis Services for RDCs Preclinical research is a crucial phase in the drug development process, particularly for Radiopharmaceuticals and Drug Conjugates(RDCs). ...
Offerings include comprehensive support in drug development, preclinical research, animal models, and strategic planning.Learn more about: cancer vaccine adjuvant development service ...
Understanding the Importance of Animal Models Animal models serve as biological proxies for human disease, allowing scientists to study complex biological interactions and disease pathways. ...
Moreover, the services on ovarian cancer model development allow researchers to utilize state-of-the-art preclinical models that closely mimic human ovarian cancer biology. These models enable the in-depth study of tumor behavior and therapeutic response, facilitating the discovery of novel treatment avenues tailored to ...
Various preclinical models have been developed to mimic the multifaceted nature of NAFLD. ...