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Preclinical Research Articles & Analysis
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Abstract Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. Knowledge of these risks has led to a growing interest in cannabis vaporizers, which heat the dry cannabis flower without burning. Vaporizing cannabis still releases ...
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes. To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely ...
In recent years, recombinant ELANE protein has become an indispensable tool for researchers studying neutrophil function, protease regulation, and disease mechanisms, particularly in pulmonary, hematologic, and inflammatory contexts. ...
As a natural inhibitor of pathological mineralization, MGP has attracted significant attention in cardiovascular and skeletal biology research. The development of recombinant MGP protein has enabled researchers to study the molecular mechanisms of calcification control and evaluate therapeutic interventions in a variety of disease contexts. ...
For example, in conditions like rheumatoid arthritis or lupus, researchers can pinpoint which autoantigens share similarities with microbial antigens. ...
Advanced methods, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), are indispensable tools. They allow researchers to: (1) Investigate Endocrine Mechanisms: Advanced analysis techniques help researchers study steroid hormone imbalances associated with various conditions, including cortisol dysregulation, reproductive disorders, and adrenal ...
Alfa Cytology works to establish cooperative relationships between academic institutions and research organizations. According to active collaboration with scientists and clinical experts, the company promotes innovation and speeds up laboratory discoveries to help preclinical practice. ...
To develop more effective treatments, it is essential for researchers to work with animal models that closely replicate human cardiac physiology. In a notable step forward, Pius et al. present a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which incorporates implantable defibrillators and addresses many limitations seen in previous ...
Alfa Cytology maintains a commitment to creating collaborative partnerships with academic institutions and research organizations. The company seeks to advance innovation and improve the preclinical implementation of laboratory breakthroughs through its collaboration with scientists and oncologists. ...
Pre-Clinical Analysis Services for RDCs Preclinical research is a crucial phase in the drug development process, particularly for Radiopharmaceuticals and Drug Conjugates(RDCs). ...
“We are excited to provide researchers with access to advanced technologies and extensive support crucial for their transformative studies.” In summary, Alfa Cytology excels in delivering vital services for cancer immunotherapy and cell therapy research, enabling scientists and researchers to push the boundaries of current knowledge and develop ...
Preclinical drug discovery represents a critical phase in the development of new therapeutics. ...
These models can recapitulate aspects of human physiology, pathology, and behavior, making them indispensable in translational research. Various species, including rodents, primates, and even larger mammals, are employed depending on the disease context and research requirements. ...
Moreover, the services on ovarian cancer model development allow researchers to utilize state-of-the-art preclinical models that closely mimic human ovarian cancer biology. ...
These avant-garde solutions are built upon a profound understanding of tumor immunology and cellular signaling pathways, empowering researchers to strengthen research on experimental therapies. “Our cancer immunotherapy development services embody our unwavering commitment to empowering oncology research and innovation,” stated the ...
They help pharmaceutical companies, research institutions, and healthcare providers to advance leukemia care through cutting-edge therapies. In the preclinical research stage, they work together to seek almost perfect innovative solutions and hope to make them easily accessible and affordable. ...
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints. These assessments continuously evolve, aiming to mitigate the incidence of cardiovascular toxicity that may emerge during clinical trials. To shed light on the ...
The service encompasses the entire preclinical development lifecycle of therapeutic antibodies—ranging from initial conceptualization and engineering to rigorous quality assurance assessments. ...
Breast cancer remains one of the most prevalent malignancies affecting women worldwide, necessitating innovative approaches for effective treatment and research. Among the most promising strategies in this endeavor are the use of tumor models for breast cancer and the development of customized antibody-drug conjugates (ADCs). ...
By utilizing premade AAV particles, researchers can bypass the complexities often associated with the production and purification of viral vectors, thus saving time and resources. The availability of premade AAV particles allows for a more accessible approach to gene therapy research. Researchers can focus on experimental design and therapeutic ...