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Prostate Articles & Analysis
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Meanwhile, hormone therapy APIs focus on hormone-dependent cancers, such as breast and prostate cancers, by blocking the hormones that promote cancer cell proliferation. ...
Provenge, a therapeutic vaccine for metastatic prostate cancer that has demonstrated a survival benefit in clinical trials, is approved for treating metastatic prostate cancer. ...
At that time, based on identification of recurrent genomic alterations in the eight most deadly cancers and their ranking on the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), NGS was recommended for advanced non-squamous non-small-cell lung cancer (NSCLC), prostate cancer, ovarian cancer and cholangiocarcinoma. It was additionally noted as an alternative to ...
Prominent tumor-associated antigens include mucin-1 (MUC1), human epidermal growth factor receptor 2 (HER-2), cancer-testis antigen 1 (NY-ESO-1), T cell-recognized melanoma antigen 1 (Melan-A or MART-1), prostate-specific antigen (PSA).AntifungalEradicating invasive fungal infections often requires months to years of continuous drug administration, increasing the risk of ...
Additionally, CD73 expression was found to be downregulated in advanced-stage prostate, laryngeal, and high-grade colon carcinomas. Lower CD73 expression levels were observed in poorly differentiated and advanced-stage endometrial carcinomas compared to normal and well-differentiated, early-stage tumors, with higher CD73 expression associated with improved overall survival[23]. ...
It is currently undergoing multiple clinical trials and is used alone or in combination to treat metastatic triple-negative breast cancer (first-line or adjuvant treatment), metastatic breast cancer, non-small cell lung cancer, metastatic Urothelial carcinoma, metastatic castration-resistant prostate cancer, and other solid tumors. Other Trop-2 ADC Drugs in Development l ...
Flotufolastat F 18 binds to prostate-specific membrane antigen (PSMA) (IC50= 4.4 nM) expressed on cells, including prostate cancer cells. In patients with recurrent prostate cancer who require local treatment, positron emission tomography (PET) with an 18F-labeled ligand provides accurate diagnostic imaging. The 18F group in Flotufolastat is a ...
Recently, in the renowned academic journal Nature Medicine, the Kimmel Cancer Center at Johns Hopkins University published Phase 2 clinical results regarding enoblituzumab, a monoclonal antibody targeting B7-H3, for the treatment of prostate cancer. The results demonstrate that enoblituzumab can successfully induce the body's anti-cancer activity, showing favorable therapeutic ...
Okra extract can activate the central nervous system of male organs. It is effective for prostatitis, weak male sexual function and endocrine disorders. 3 Extraction methods of plant extract 3.1 Aqueous extraction: This method is used to extract water-soluble substances including polysaccharides, organic acids, saponins, phenols, tannins, proteins and other substances. 3.2 ...
Enzymes that are specific to the disease itself are often used to diagnose and monitor cancer, heart disease, and liver disease. For example, prostate-specific antigen (PSA) is an enzyme that is produced by the prostate gland and is used to diagnose and monitor prostate cancer. ...
For example, a TPD drug developed by Arvinas has achieved proof-of-concept in clinical trials for the treatment of breast and prostate cancer. Researchers are also developing TPD drugs to treat other types of diseases. ...
For example, the enzyme lactate dehydrogenase (LDH) is often used as a marker for cancer progression, as increased levels of LDH in the blood can indicate tumor growth. Another enzyme, prostate-specific antigen (PSA), is commonly used to diagnose and monitor prostate cancer. ...
X-ZELL is collaborating with Singapore General Hospital (SGH) and the National University Hospital Singapore (NUH) to explore how X-ZELL single-cell diagnostics may aid in the early detection of clinically significant prostate cancer in whole blood. The prospectively blinded, 400-patient multi-centre study officially commenced in 2020 and will lay the foundation for the launch ...
The literature shows that pathologists, being only humans under considerable pressure, may miss cancer in up to 1-3% of prostate biopsies.2,3,4 Considering the over one million men who are diagnosed worldwide per year, this may reflect a large number of patients.5 Moreover, the subjectivity of Gleason grading and tumor quantification can result in difficulty assigning effective ...
By comparing the toxicity of chitosan oligosaccharides with different molecular weights and different degrees of deacetylation to prostate cancer cells PC3, lung cancer cells A549 and liver cancer cells HepG2, the researchers found that chitosan with low molecular weight and low degree of deacetylation has Better anti-tumor effect. ...
Comparative effect of gold nanorods and nanocages for prostate tumor hyperthermia. Journal of Controlled Release, 220, 245-252. 4. ...
Currently, ADC has played a significant role in the treatment of some malignant tumors, such as trastuzumab in the treatment of breast cancer, but its application in the treatment of prostate cancer (PCa) progress slowly. In recent years, ADC has made rapid progress in the treatment of metastatic castration-resistant prostate cancer (mCRPC). ...
Moreover, LFQ is commonly used in biomarker detection of other diseases and tumors, such as Vps35 for Parkinson's disease, SOAT1 for hepatocellular carcinoma, GOT2 for prostate cancer, A1AT for bladder cancer. Stable isotope labeling with amino acids in cell culture (SILAC) Stable isotope labeling with amino acids in cell culture is an in vivo metabolic labeling method, which ...
While Movember is not just about prostate cancer, it is a great place to start; prostate cancer is the second most common cancer among men worldwide1, and the second leading cause of cancer death in American men.2 In the UK, more than 52,000 men are diagnosed with prostate cancer every year on average – which is 143 men every day, according ...
You may have heard of Movember, the month when men grow their facial hair in solidarity with men’s health issues, like testicular and prostate cancer. The trend has taken hold across the world and even generated its own spinoffs, like “No-Shave ...