Renal Impairment Articles & Analysis
3 articles found
Thus, it underpins the development and adjustment of an individual's therapeutic regimen, including considerations for patients with renal or hepatic impairments. While maintaining a close relationship with PK studies, Toxicokinetic studies primarily square on the adverse effects resulting from drug intake or exposure to a toxic substance. ...
Here’s what we know so far about some of these risk factors and their involvement in the progression to HFpEF: Aging Structural and functional changes related to aging are believed to be significant risk factors of HFpEF, for example, ventricular arterial stiffening, vascular dysfunction, impaired Ca2+ regulation, and physical deconditioning. [5] HFpEF has traditionally ...
In the Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARESS-HF)49 study, ultrafiltration led to hemodynamic improvement but was not beneficial for patients who had already developed renal impairment and was associated with an increased number of adverse events.50 The discrepancies in these study results suggest that ultrafiltration may be useful ...