sepsis Articles
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Galectin-3 Aggravates Experimental Polymicrobial Sepsis by Impairing Neutrophil Recruitment to the Infectious Focus
Annotations Serum Gal-3 concentration increased in patients with septic shock and mice undergoing sepsis induced by a procedure called cecal ligation and puncture (CLP). Mice genetically deficient in Gal-3 (Gal-3 KO) were more resistant to sepsis caused by CLP than wild-type mice (WT). Gal-3 KO mice show an increased number of neutrophils in the initial stage of infection and reduced ...
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Improved Sepsis Detection & Compliance: 6 Areas your Next Solution should Address
Sepsis accounts for over 20% of deaths worldwide (WHO) and 85% of cases occur in low-resource settings.But this isn’t a problem mostly owned by third-world countries with inadequate equipment and detection technology. In the U.S., less than 50% of patients are correctly treated for sepsis, mostly due to clinicians missing the timeline for treatment. The problem is so widespread that ...
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Galectin-3 in septic acute kidney injury: a translational study
Abstract Background: Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed to explore Gal-3's role and its potential utility as a therapeutic target in S-AKI. Methods: In 57 patients admitted to the intensive care unit (ICU) with ...
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Critical review on hospital surgical room and mechanical system designs
The design of HVAC systems for surgical operating rooms requires specific guidance for the design engineer in order to insure that thermal comfort and sepsis control are maintained at all times in order to protect the occupants of the room. Operating room ventilation has been through significant design improvements from the beginning of the 20th century until now. Researchers have found that the ...
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Mid-Size Laboratories Can Now Enjoy the Same Efficiency Benefits as Large Facilities with Beckman Coulter’s New Hematology Analyzer
Beckman Coulter , a global leader in clinical diagnostics, today announced the commercial launch of its new DxH 690T hematology analyzer. Designed to help laboratories streamline workflow and maximize uptime, the DxH 690T offers all the benefits of the company’s flagship DxH 900 hematology analyzer to mid-size labs, including an industry-leading 93% first-pass yield and the recently ...
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Newly Released FDA Guidelines for Sepsis Detection & what it Means for Hospitals
Executive Brief On September 28, 2022, the FDA released Clinical Decision Support, Guidance for Industry and Food and Drug Administration Staff. This guidance is long overdue, and with it comes the elimination of any protections for EHRs, or any other vendors, to pretend it’s OK to sell or deploy solutions for patient monitoring and care for life-threatening conditions like sepsis, that ...
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What is Sepsis? Key Symptoms, Potential Complications, and Vital Treatment
The term sepsis describes the body's extreme response to infection. When a person suffers from sepsis, his or her immune system has been triggered in response to an infection, which causes inflammation and damages tissues in the body. Symptoms of Sepsis The symptoms of sepsis may include: Fever (102 degrees Fahrenheit or higher) Chills Rapid breathing (above 20 breaths per minute) or ...
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The Role of Lactate in Sepsis Research
Sepsis reportedly affects up to 30 million people each year. Lactate levels play a key role in diagnosing the condition and limiting its impact, as well as researching it's progression and developing possible treatments. Here's how. Sepsis is a medical condition and emergency, the definition of which has proven difficult and is based on fairly recent developments and research. It is the result ...
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Many Faces of Sepsis (1): Cancer Therapy and Management Febrile Neutropenia - Case Study
The purpose of this case study is to highlight ways in which medical algorithms can be integrated into the clinical decision making process. This case study is the first of a series focused on sepsis, a common but complex clinical problem. Use of algorithms can help healthcare providers diagnose sepsis early. Throughout our discussion, appropriate algorithms are suggested to help clinicians ...
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On a Mission to ZERO False-Positive Blood Cultures
Improve sepsis testing accuracy. Enhance patient safety. These are the driving forces behind Magnolia Medical Technology’s Mission to ZERO. Mission to ZERO™ is a nationwide plan to create greater awareness of patient safety and antibiotic-associated risks caused by false-positive diagnostic test results for sepsis. The goal is to initiate change by improving national blood culture ...
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Kurin, Inc. honored by MD Tech Review in annual listing of top Infection Control solutions
The New Standard for Blood Culture Collection Sepsis, is a life-threatening condition caused when the body’s response to an infection goes out of balance, which triggers changes that damage other organs. This deadly infection affects almost 1.7 million people a year in the U.S. and kills nearly 270,000 people. To date, blood cultures remain the gold standard for determining if a patient ...
By Kurin, Inc.
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Special Genes May Affect the Level of Lipopolysaccharide in the Body’s Blood
Transfer of lipopolysaccharide from gram-negative bacteria into the systemic circulation of the body leads to the development of endotoxemia, which is detected in cardiometabolic diseases such as cardiovascular disease and obesity in addition to acute infections. Lipopolysaccharide is a virulence factor produced by bacteria, which often triggers systemic inflammation through the body's ...
By CD BioGlyco.
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Freehand Transperineal Biopsy
“Freehand transperineal biopsy” seems to be the latest buzzword in the urology world, and for good reason. Compared to transrectal, transperineal is proven to be the cleaner and ultimately safer approach for prostate biopsies. The support for transperineal is growing, as mounting evidence continues to debunk previous misconceptions of tolerability, feasibility and accuracy. We ...
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New Findings about Capsular polysaccharide You May Want to Know
Streptococcus pneumoniae is the leading cause of pneumonia, sepsis and meningitis. Collectively, these infections are a leading cause of morbidity and mortality in older adults and young children. To fight these deadly infections, a pneumococcal vaccine is given to stimulate the production of antibodies against CPS. However, bacteria can manipulate their CPS structure to evade these antibodies. ...
By CD BioGlyco.
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NIH: `Probiotic bacteria block harmful microbe`
“This is one of the first studies to describe precisely how they may work to provide health benefits. The possibility that oral Bacillus might be an effective alternative to antibiotic treatment for some conditions is scientifically intriguing and definitely worthy of further exploration.” At a Glance Researchers identified how one microbe prevents the growth of harmful ...
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The Spark for Decoding Biology: An Origin Story
Recursion is entering an exciting period in our evolution as a clinical-stage biotechnology company. We recently announced that we’ve enrolled the first patient in the first human efficacy trial in our company’s history — a significant milestone for us, and for the patients we hope to serve. Our Phase 2 trial is investigating the treatment of a disease called cerebral ...
By Recursion
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Extra Innings: Kevin Kronmiller’s Story - Case Study
The Problem: When Kevin Kronmiller was 22, he found out he had 5 years to live if he didn't receive a liver transplant. Beating the odds, Kevin made it to 50 before needing a liver transplant. After his surgery, Kevin went into Septic Shock. He found out later from his physicians that he had a 30% chance of survival and even if he did survive, doctors were very concerned about long-term ...
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Why Sterile Packaging is Crucial for Medical Devices
Patients who need medical treatment often fear being exposed to harmful germs and unsanitary instruments. Just the thought of a healthcare provider using an unsterilized surgical device or needle is enough to make people feel queasy. As a result, patients find it reassuring to watch a clinician remove healthcare devices from sterile packaging before starting a procedure. Sterile packaging ...
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Vaccine Projects
Abera’s vaccine delivery platform works as a plug-and-play system where known or novel antigens can be engineered onto our delivery platform to create effective, multivalent vaccines that are cost-effective and fast to produce. We actively work together with academia and industry to enable the use of our vaccine delivery platform in design and development of new vaccines. Many of these ...
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Surgical Site Infection: Methods of Prevention & Tools for Predicting Risk - Case Study
Medical History A 55-year-old white male has degenerative arthritis of the knees. 10 months ago, the patient underwent total knee replacement on the left knee without complication. The surgical incisions had closed without signs of surgical site infection. At the time, he made a good recovery. He is fully functional and fully independent. Patient is a chain smoker with a wife and two children. He ...
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