skeletal development Articles
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Exposure to a PBDE/OH‐BDE mixture alters juvenile zebrafish (Danio rerio) development
Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g. hydroxylated BDEs (OH‐BDEs)) are contaminants detected together frequently in human tissues, and are structurally similar to thyroid hormones (TH). THs partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window which may be vulnerable to chemicals disrupting thyroid ...
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Spatial profiling of chromatin accessibility in mouse and human tissues
Abstract Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2,3,4,5, but the ability to capture spatial epigenetic information of tissue at the cellular level and genome scale is lacking. Here we ...
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