Small Molecule Targeted Drug Articles & Analysis
48 articles found
Antibody-drug conjugates (ADCs) combine potent small-molecule drugs with monoclonal antibodies for targeted cancer therapy. ...
As spring arrives, so does a renewed focus on cleaning, quality, and process validation in pharmaceutical facilities. Whether it’s a routine seasonal turnover or preparation for ramped-up production cycles, spring is a critical time in the pharmaceutical industry for equipment maintenance, cleaning validation, and ensuring product purity. Behind every cleanroom, batch reactor, or ...
As spring arrives, so does a renewed focus on cleaning, quality, and process validation in pharmaceutical facilities. Whether it’s a routine seasonal turnover or preparation for ramped-up production cycles, spring is a critical time in the pharmaceutical industry for equipment maintenance, cleaning validation, and ensuring product purity. Behind every cleanroom, batch reactor, or filtration ...
Recombinant protein drugs are protein-based therapeutic drugs which are produced by using DNA recombination technology or other biotechnological methods. These drugs include cytokines, peptide hormones, recombinant enzymes, monoclonal antibodies, and fusion proteins. Compared to traditional low-molecular-weight synthetic drugs, recombinant protein drugs have advantages such as high specificity, ...
Recombinant protein drugs refer to protein products derived from animals or plants and developed through biotechnology research. These proteins possess certain biological activities and can prevent, treat, and diagnose diseases in humans, animals, and plants. Compared to small molecule drugs, protein drugs have advantages such as high activity, high specificity, and low toxicity, making them ...
Studying changes in protein phosphorylation in these diseases can help reveal the molecular mechanisms of these conditions.3. Drug DevelopmentBy screening small-molecule drugs that affect protein phosphorylation levels, potential drug targets and candidate drugs can be ...
Pharmacokinetic characteristics are composed of and determined by drug absorption, distribution, metabolism and excretion. The structure, physiological properties and pharmacokinetic characteristics of monoclonal antibodies are different from those of traditional small molecule drugs. For example, their molecular weight, volume ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. ...
Since antibody-drug conjugates (ADCs) have the molecular characteristics of both small molecule and macromolecule therapeutic drugs, when choosing analytical methods, the typical ones used for both should all be considered. ...
Alfa Cytology has announced its small molecule drug development to advance preclinical cancer research. ...
Moreover, they can further elucidate the targets and provide an effective environment for developing new drugs. ...
In the vast realm of drug discovery, the fusion of computational prowess and intricate molecular details has given birth to the revolutionary field of protein-small molecule docking. ...
Ongoing research and inventions in the field of oncology focus on the development of small molecule drug therapies for use in brain tumor resection. Small molecule drugs are being developed to target and effectively treat brain tumors to improve therapeutic outcomes. ...
However, thanks to advancements in medical research and technology, significant progress has been made in the field of rare disease research, from developing accurate diagnostic tools to making effective small-molecule drugs. One of the biggest hurdles in treating rare diseases is accurately diagnosing them. ...
Nanogels (NGs), namely nanoscale hydrogel particles, are three-dimensional network systems formed by physical or chemical cross-linking of polymers. Nanogels have received widespread attention in recent years due to their unique properties and potential applications in various fields such as drug delivery, tissue engineering, and diagnostics.Classification of NanogelsAccording to the phase change ...
We have cytotoxins in a variety of formats, including unconjugated drugs, drug-linker conjugates and drug-antibody conjugates, to meet the specific needs of different research projects.Types of Drug ConjugatesDrug conjugates are a promising method of drug delivery that combine the specificity of ...
The classical mode of action of small molecule drugs is "occupancy-driven". Since the FDA approved the first oral small molecule targeted therapy for tumors-tamoxifen targeting the estrogen receptor (ER)-in 1977 for the treatment of breast cancer, small ...
This article analyzes each aspect.DefinitionsSMDC consists of a small molecule drug (usually a highly active chemotherapy drug) and a targeting ligand (usually a small molecule), connected through conjugation technology. ...
The use of AI to develop new drugs is to simulate the process of drug screening by computer to predict the activity of compounds, and then conduct targeted physical screening of potential compounds. Machine learning (ML) The method of using AI in the discovery of small drug-like molecules ...
They have shown promising results in delivering both small molecule drugs and macromolecules such as proteins and peptides. ...