spinal Articles
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Evaluation of melatonin for modulation of apoptosis-related genes in irradiated cervical spinal cord
This study examined the role of melatonin to reduce radiation-induced apoptosis in rat's cervical spinal cord. A number of rats were divided into four groups: (1) control group; (2) group that was treated with intraperitonial injection of melatonin; (3) group that got melatonin 30 min prior to cervical spinal cord gamma irradiation at a dose of 22 Gy; and (4) group that was given an ...
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Postoperative Spinal Instability at L3-4 Revealed by Upright Weight-Bearing MRI - Case Study
The patient was scanned in the FONAR Upright MRI in early 2002, one year after her spinal fusion. Both Upright and recumbent scans were performed on her in the multi-position FONAR Upright MRI. The recumbent MRI (left image) exhibited only a normal lumbar lordotic curve and a modest bulge of the L3-4 intervertebral disc, consistent with her prior recumbent MRI scan on a conventional MRI. The ...
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Understanding Lumbar Spinal Stenosis with Neurogenic Claudication
What is Lumbar Spinal Stenosis? Lumbar spinal stenosis, or LSS, is a common condition in which the lower spinal canal narrows and compresses the nerves in the lower back. Lumbar spinal stenosis is generally caused by aging and natural wear and tear on the spine. With lumbar spinal stenosis, thickened ligament, overgrowth of bone, and/or bulging discs in the lower back put pressure on the ...
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Biomechanical Evaluation of an In Situ Cured Silicone Rubber Nucleus Replacement Device
A new intervertebral disc nucleus replacement device having three major features has been designed, comprising: 1) a peripheral textile band, 2) a silicone membrane filled with silicone that cures in situ forming an elastomeric implant and 3) an internal chamber that allows for deformation of the cured component (Figure 1). Samples of this device were subjected to biomechanical flexibility ...
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Bladder management practice for spinal cord injury patients
The spinal cord is to relay messages between the brain and the rest of the boy. When spinal cord injury happens the body may lose some essential functions if the nerves can’t communicate with the brain. Inadequate bladder management of spinal cord injury (SCI) results in medical complications, psychological stress and even mortality. Frequent leakage of urine causes soiling of clothes ...
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After a spinal cord injury, can we predict who will recover independent bowel management during the first year?
Neurogenic bowel dysfunction (NBD) with symptoms of constipation and fecal incontinence is a common complication of traumatic spinal cord injury. In a new study, the aim was to identify factors that could predict the recovery of independent bowel function to assist clinicians in their prognosis of bowel function and to guide them to bowel management strategies useful for the patient. Bowel ...
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The Best Ways to Banish Back Pain
An article from Health in Action features mild® Provider, Dr. Kiran Patel and reviews key data from the Mobility Matters Landmark Survey as well as the Know Your Back Story health awareness campaign. Key points: Count yourself lucky if you’ve never groaned about your back. It is estimated that roughly a quarter of us- more than 72.3 million U.S. adults- are currently experiencing ...
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Techniques for measuring the activity of the deep muscles: Literature review
Summary Due to their anatomical positioning, contraction of the deep abdominal muscles is often difficult to feel and therefore for patients to master. However, they are actively involved in spinal (or lumbar spine) stabilisation, and also in several biological processes [1]. They therefore constitute an important target in several physiotherapeutic treatments [1]. Questions are often raised ...
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Marsi-Bionics presents the clinical successes of its exoskeletons to internal medicine doctors
The Atlas 2030, the world's only exoskeleton for children, is capable of achieving much more effective therapy in the treatment of Spinal Muscular Atrophy The Mak Active Knee, the exoskeleton that works like a robotic knee, is achieving previously impossible rehabilitations due to speed and absence of pain Elena Garcia Armada, founder of Marsi-Bionics and scientific researcher at the CSIC, ...
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VetStem Cell Therapy Helps Senior Lab Walk Again
We absolutely love hearing stem cell success stories from pet owners. But some stories are extra touching because it’s clear that VetStem really improved a pet’s quality of life. That’s the case with Molly, a senior chocolate lab who was suffering from severe osteoarthritis and a potential spinal ...
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Biomechanical Flexibility Testing of an in Situ-Cured Silicone-Based Disc Nucleus Prosthesis
A new intervertebral disc nucleus replacement device having three major features has been designed, comprising: 1) a peripheral textile band, 2) a silicone membrane filled with silicone that cures in situ forming an elastomeric implant and 3) an internal chamber that allows for deformation of the cured component (Figure 1). Samples of this device were subjected to biomechanical flexibility ...
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Ultrastructural characterisation of the hydroxyapatite–coated pedicle screw and human bone interface
The early fixation of pedicle screws is crucial for improving spinal stabilisation. Firm and immediate fixation between pedicle screws and bone prevents aseptic loosening and implant failure. Coating with hydroxyapatite is a possible method to improve the fixation of metallic implants in bone. In this study, scanning transmission electron microscopy (STEM) has been used to investigate the ...
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Easing Chronic Pain Remotely With Digital Health - Case Study
Living with Chronic Pain Rich is a 20-year veteran consultant at a Big Four accounting firm, who spends long hours sitting at his desk on his computer. The past 2 years, his back pain has become unbearable. He tried epidurals, surgery, physical therapy, and opioids and was waking up every 3 hours to take a pill that barely helped. He had fractures on his spine’s base. After being bed-ridden ...
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World’s First aprevo Personalized Spine Surgery Performed Using the Only Available Spine Technology with FDA Breakthrough Designation
SAN DIEGO--(BUSINESS WIRE)--Carlsmed, Inc. is announcing today that the firstaprevopatient specific spinal surgery has been successfully performed. Christopher Ames, M.D., director of spinal tumor and spinal deformity surgery at UC San Francisco Medical Center, assisted by Patrick Maloney, M.D., performed this landmark surgical procedure. “Carlsmed’s aprevofamily of devices represent ...
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How to Take Care of your Mental Health After a Spinal Cord Injury
An injury to your spinal cord changes your life dramatically. Paralysis in both arms and legs forces you to come to terms with your body that no longer functions like it used to. You’ll have to rethink how you go about those daily activities that’s easily taken for granted - how you work, eating dinner, using the bathroom and using technological devices like the phone, tablet or ...
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Application of refractable nanocomposite on cell based therapy in central nervous system
Quantum Dots (QDs) are nano–particles carrying high stability fluorescence to follow the grafted cells which can be used in investigating the movement of cells and understanding the organogenesis of stem cells during development and wound repair processes in adulthood. For its easy acquirement and bypassing moral ethical issues, it makes the human adipose derived stem cells an attractive, ...
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The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene
Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder caused by the homozygous loss of the SMN1 gene. The human SMN2 gene has a C-to-T transition at position +6 of exon 7 and thus produces exon 7-skipping mRNAs. However, we observed an unexpectedly high level of exon 7-containing SMN2 transcripts as well as SMN protein in testis of smn–/– SMN2 transgenic mice. Using affinity ...
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Carlsmed Raises $30M in Series B Funding to Scale Personalized Spine Surgery
CARLSBAD, Calif.--(BUSINESS WIRE)--Carlsmed announced today that it closed an oversubscribed $30M Series B funding round, led by B Capital Group, a global, multi-stage investment firm. Existing investors, U.S. Venture Partners, The Vertical Group, Cove Fund and Wavemaker Three-Sixty Health, also participated in the round. The company plans to use the Series B funds to ramp commercialization of ...
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Enhanced bioactivity and osseointegration of PEEK with accelerated neutral atom beam technology
Abstract Polyetheretherketone (PEEK) is growing in popularity for orthopedic, spinal, and trauma applications but has potential significant limitations in use. PEEK is biocompatible, similar in elasticity to bone, and radiolucent, but is inert and therefore does not integrate well with bone. Current efforts are focusing on increasing the bioactivity of PEEK with surface modifications to improve ...
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Abstract Reactive astrocytes are associated with every form of neurological injury. Despite their ubiquity, the molecular mechanisms controlling their production and diverse functions remain poorly defined. Because many features of astrocyte development are recapitulated in reactive astrocytes, we investigated the role of nuclear factor I-A (NFIA), a key transcriptional regulator of astrocyte ...
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