stem cell differentiation Articles
-
Mesenchymal Stem Cell Microenvironment
Mesenchymal stem cells (MSC) differentiate towards multiple lineages that participate in bone formation and are often utilized for bone regeneration therapy. A 2019 review by Lee et al. explores the endogenous mechanical and biochemical environment of MSCs. Additionally, the article highlights the essential factors that lead to bone repair and how these factors can be leveraged to improve bone ...
-
Understanding Induced Pluripotent Stem Cell Differentiation and the Role of iPSC Differentiation Kits in Biological Research
Pluripotent stem cells — cells with the ability to differentiate into nearly any cell type in the body, constituting a significant potential for regenerative medicine. Among these, induced Pluripotent Stem Cells (iPSCs), in particular, have garnered substantial interest from the scientific community due to their ability to be produced from adult cells, eliminating the ethical quandaries ...
-
New Findings about BRD4 Protein You May Want to Know
A new study clarifies how BRD4 (a protein that scientists have studied for many years) directs the spatial organization of DNA in the cell nucleus (a key function of stem cells to differentiate into muscle cells), which promotes the understanding of certain cancers and complex congenital diseases. Since the way DNA is folded is essential for gene regulation, this research not only has ...
-
CD Genomics Perspective: RNA Sequencing, A Powerful Method for Studying Various Diseases
Although post-mortem brains have been frequently reported as the "gold standard" in transcriptomic research for ND and neuropsychiatric abnormalities, the main sources has been mRNA separated from transgenic animal models and, more lately, patient-derived cell lines. However, despite their promise, transcriptome studies are difficult due to the obvious difficulties in obtaining brain tissue and ...
By CD Genomics
-
Cytokines: Characteristics, Applications, and Quantitative Analysis
Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. Cytokines play pivotal roles in ...
-
Enhancing Human Gut Tissue Models through Gene Editing
The variety of normal and diseased human tissues needed to perform comprehensive screening of drug candidates is a key resource for next-generation preclinical models, but obtaining these tissues is challenging. Gene editing enables Altis Biosystems to offer a diverse array of RepliGut® human gut models tailored for specific research programs. Many Challenges Around Accessing Tissues ...
-
Accurately Recapitulating Environmental Niches in Vitro Models of the Intestine
Advanced microphysiological systems can replicate aspects of intestinal complexity, such as epithelium self-renewal by stem cells in in vitro crypts or the interactions of microbes and intestinal epithelium mediated by a mucus layer. Availability of such models is key to progress in compound screening, disease modeling, and microbiome research. Defining a Niche A niche is a multidimensional ...
-
Exploring the Potential of RNA-Seq in Various Fields
What is RNA-Seq? Regulation of gene expression is fundamental to linking genotypes with phenotypes. RNAs shape complex gene expression networks, which drive biological processes. An in-depth understanding of the underlying mechanisms of how to govern these complex gene expression networks is vital for the treatment of complex diseases such as cancer. Hybridization-based microarrays are used to ...
By CD Genomics
-
Increasing the Efficiency of Drug Development with Preclinical Testing Using Human Intestinal Stem Cells
Due to a lack of robust in vivo gut models, animal studies are generally required to evaluate gut toxicity. However, these studies can be lengthy and expensive and may not accurately recapitulate the behavior of the human gastrointestinal tract. Drugs are thus often developed with undesired gut side effects that are not apparent until clinical trials. Organ-on-a-chip models are the closest ...
-
COREX Case Studies
Explore how surgeons are using COREX to harvest cancellous bone graft using a minimally invasive ...
-
Recapitulating the Multifaceted Inflammatory Environment of the Intestine In Vitro
Intestinal inflammatory diseases are highly complex, which has thus far prevented development of an effective in vitro disease model. With access to a donor-derived cell biobank and the ability to recapitulate region-specific environments of the intestine, Altis Biosystems is working toward the development of an in vitro RepliGut® model to accurately recapitulate the complex intestinal ...
-
Punctuating messages encoded in human genome with transposable elements
San Francisco, CA - Since the classical studies of Jacob and Monod in the early 1960s, it has been evident that genome sequences contain not only blueprints for genes and the proteins that they encode, but also the instructions for a coordinated regulatory program that governs when, where and to what extent these genes and proteins are expressed. The execution of this regulatory code is what ...
-
High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue
Highlights Deterministic barcoding in tissue enables NGS-based spatial multi-omics mapping DBiT-seq identified spatial patterning of major tissue types in mouse embryos Revealed retinal pigmented epithelium and microvascular endothelium at cellular level Direct integration with scRNA-seq data allows for rapid cell type identification Summary We present ...
-
Evaluating Microbiome Therapies with Intestinal Cell Models
The microbiome has been shown to play roles in many different disease processes and is implicated in many more, from infectious and gastrointestinal diseases to autoimmune and neurological disorders. Advanced models of the gut leveraging intestinal and colonic stem cells are enabling the development of more reliable and robust systems for evaluating the impact of changes in the microbiome on gut ...
-
The Power Of RepliGut in Vitro Intestinal Stem Cell Models
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. RepliGut®, an in vitro human intestinal epithelial stem cell model, addresses many of these issues and has significant potential to reduce the time and cost of drug development. This model may even help to identify optimal therapies for ...
-
A Closer Look at Reporter Lentiviral Particles: Tool for Biomedical Research
Introduction For years, scientists have leveraged the brilliant potentialities of genetic science to explore how cells function and interact in living organisms. Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the ...
-
How Does Altis Biosystems Envision the Future of the Pharma/Biopharma Industry?
There is a growing need to address the high failure rate of drug candidates as they progress through clinical trials. Altis Biosystems aims to bring its technological advances to the forefront, enabling the drug development process to more effectively translate results from preclinical experiments to late-stage clinical trials. Breaking the Conformity of Inadequate Testing Platforms The ...
-
Cytokines: The Master Regulators of Immunity and Inflammation
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
-
Developing a Robust in Vitro Intestinal Model for Preclinical Candidate Screening of GI Toxicity
Gastrointestinal (GI) issues are common side effects of many drugs. Anticipating such side effects before clinical trials is limited by a lack of effective models for evaluating preclinical candidates for their potential to cause diarrhea, nausea, and other gut-related side effects. With its RepliGut® in vitro human intestinal model, Altis Biosystems is developing a system that could help ...
-
What is Nano Dressing?
Nanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new treatment methods for wound repair and burn care, such as nanohydrogels, nanofibers, nanomembranes, ...
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you